In vivo depletion of T-cell subsets in cattle

Techniques for in vivo depletion of lymphocytes using monoclonal antibodies have been well documented for murine systems. This model has played an important role in analysing the involvement of various lymphocyte subsets in several immune mechanisms. In mice 600 ug of Ab are generally injected intra...

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Bibliographic Details
Main Authors: Scheerlinck, J.P., Naessens, Jan
Format: Conference Paper
Language:Inglés
Published: International Laboratory for Research on Animal Diseases 1995
Subjects:
Online Access:https://hdl.handle.net/10568/2829
Description
Summary:Techniques for in vivo depletion of lymphocytes using monoclonal antibodies have been well documented for murine systems. This model has played an important role in analysing the involvement of various lymphocyte subsets in several immune mechanisms. In mice 600 ug of Ab are generally injected intraperitoneally once a week. In order to study bovine specific immune mechanisms we have attempted to adapt this technology to cattle.