Bovine T-cell responses to defined Trypanosoma congolense antigens during infection
Infections of cattle with tsetse-transmitted Trypanosoma congolense are accompanied by antibody responses to the variable surface glycoprotein (VSG) and to two major invariant antigens, a member of the hsp 70 family and a 33KDa cysteine protease. During primary infection, trypanotolerant N'Dama (Bos...
| Autores principales: | , , , |
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| Formato: | Conference Paper |
| Lenguaje: | Inglés |
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International Laboratory for Research on Animal Diseases
1995
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| Acceso en línea: | https://hdl.handle.net/10568/2826 |
| _version_ | 1855513904521674752 |
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| author | Lutje, V. Authié, Edith Boulange, A.F. Williams, D.J.L. |
| author_browse | Authié, Edith Boulange, A.F. Lutje, V. Williams, D.J.L. |
| author_facet | Lutje, V. Authié, Edith Boulange, A.F. Williams, D.J.L. |
| author_sort | Lutje, V. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Infections of cattle with tsetse-transmitted Trypanosoma congolense are accompanied by antibody responses to the variable surface glycoprotein (VSG) and to two major invariant antigens, a member of the hsp 70 family and a 33KDa cysteine protease. During primary infection, trypanotolerant N'Dama (Bos taurus) cattle exhibit higher levels of IgG1 to CP than susceptible Borans. Boran cattle, on the other hand, have high levels of IgM to irrelevant antigens. During rechallenge infections, N'Dama cattle have higher levels of IgG1 to hsp70 while Boran cattle exhibit high titres of IgM to this antigen. Although Boran cattle do generate high titres of IgM to hsp70, N'Dama cattle develop higher levels of specific IgG antibody (Authie et al., 1993b). These observations are consistent with a possible dysfunction in isotype switch from IgM to IgG in Boran cattle. Because of the central role of T helper cells in induction of Ig isotype switch, the difference in antibody responses between N'Dama and Boran cattle migh reflect defective T helper cell function in the susceptible breeds during infection. We undertook a study to analyse T-cell function in cattle during infection with T. congolense. T-cell proliferative responses to a recombinant form of the hsp70 (R63), cysteine protease and VSG were measured in a group of Boran cattle following primary challenge with T. congolense. The role of CD4+ and CD8+ cells in the response was also investigated. |
| format | Conference Paper |
| id | CGSpace2826 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1995 |
| publishDateRange | 1995 |
| publishDateSort | 1995 |
| publisher | International Laboratory for Research on Animal Diseases |
| publisherStr | International Laboratory for Research on Animal Diseases |
| record_format | dspace |
| spelling | CGSpace28262024-03-06T10:16:43Z Bovine T-cell responses to defined Trypanosoma congolense antigens during infection Lutje, V. Authié, Edith Boulange, A.F. Williams, D.J.L. trypanosoma congolense infection animal diseases immune response disease control glossinidae ndama cattle Infections of cattle with tsetse-transmitted Trypanosoma congolense are accompanied by antibody responses to the variable surface glycoprotein (VSG) and to two major invariant antigens, a member of the hsp 70 family and a 33KDa cysteine protease. During primary infection, trypanotolerant N'Dama (Bos taurus) cattle exhibit higher levels of IgG1 to CP than susceptible Borans. Boran cattle, on the other hand, have high levels of IgM to irrelevant antigens. During rechallenge infections, N'Dama cattle have higher levels of IgG1 to hsp70 while Boran cattle exhibit high titres of IgM to this antigen. Although Boran cattle do generate high titres of IgM to hsp70, N'Dama cattle develop higher levels of specific IgG antibody (Authie et al., 1993b). These observations are consistent with a possible dysfunction in isotype switch from IgM to IgG in Boran cattle. Because of the central role of T helper cells in induction of Ig isotype switch, the difference in antibody responses between N'Dama and Boran cattle migh reflect defective T helper cell function in the susceptible breeds during infection. We undertook a study to analyse T-cell function in cattle during infection with T. congolense. T-cell proliferative responses to a recombinant form of the hsp70 (R63), cysteine protease and VSG were measured in a group of Boran cattle following primary challenge with T. congolense. The role of CD4+ and CD8+ cells in the response was also investigated. 1995 2010-12-09T11:12:00Z 2010-12-09T11:12:00Z Conference Paper https://hdl.handle.net/10568/2826 en Open Access International Laboratory for Research on Animal Diseases |
| spellingShingle | trypanosoma congolense infection animal diseases immune response disease control glossinidae ndama cattle Lutje, V. Authié, Edith Boulange, A.F. Williams, D.J.L. Bovine T-cell responses to defined Trypanosoma congolense antigens during infection |
| title | Bovine T-cell responses to defined Trypanosoma congolense antigens during infection |
| title_full | Bovine T-cell responses to defined Trypanosoma congolense antigens during infection |
| title_fullStr | Bovine T-cell responses to defined Trypanosoma congolense antigens during infection |
| title_full_unstemmed | Bovine T-cell responses to defined Trypanosoma congolense antigens during infection |
| title_short | Bovine T-cell responses to defined Trypanosoma congolense antigens during infection |
| title_sort | bovine t cell responses to defined trypanosoma congolense antigens during infection |
| topic | trypanosoma congolense infection animal diseases immune response disease control glossinidae ndama cattle |
| url | https://hdl.handle.net/10568/2826 |
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