Protective and inappropriate antibody responses in trypanosome-infected cattle
The trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a particul...
| Autores principales: | , , , , |
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| Formato: | Conference Paper |
| Lenguaje: | Inglés |
| Publicado: |
International Laboratory for Research on Animal Diseases
1995
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/2824 |
| _version_ | 1855522936639717376 |
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| author | Williams, D.J.L. Taylor, K. Newson, J. Naessens, Jan Authié, Edith |
| author_browse | Authié, Edith Naessens, Jan Newson, J. Taylor, K. Williams, D.J.L. |
| author_facet | Williams, D.J.L. Taylor, K. Newson, J. Naessens, Jan Authié, Edith |
| author_sort | Williams, D.J.L. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a particular VSG mediate the destruction and clearance to trypanosomes expressing that variant. As those parasites are cleared, they are replaced by others expressing antigenically different VSG molecules, which in turn provoke specific antibody responses. Trypanosome infections are therefore characterized by waves of parasitaemia followed by waves of VSG-specific antibody. It is known that trypanotolerant N'Dama cattle infected with Trypanosoma congolense have significantly lower levels of parasitaemia than the more susceptible Boran cattle. It has been suggested that this reflects a more effective VSG-specific antibody response in the N'Damas. We have tested this hypothesis by examining VSG-specific antibody responses in N'Dama and Boran cattle during experimental infection with T. congolense. |
| format | Conference Paper |
| id | CGSpace2824 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1995 |
| publishDateRange | 1995 |
| publishDateSort | 1995 |
| publisher | International Laboratory for Research on Animal Diseases |
| publisherStr | International Laboratory for Research on Animal Diseases |
| record_format | dspace |
| spelling | CGSpace28242024-03-06T10:16:43Z Protective and inappropriate antibody responses in trypanosome-infected cattle Williams, D.J.L. Taylor, K. Newson, J. Naessens, Jan Authié, Edith trypanosomes (phytomonas) infection immune response disease control animal diseases glossinidae glossina morsitans ndama cattle goats trypanosoma congolense The trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a particular VSG mediate the destruction and clearance to trypanosomes expressing that variant. As those parasites are cleared, they are replaced by others expressing antigenically different VSG molecules, which in turn provoke specific antibody responses. Trypanosome infections are therefore characterized by waves of parasitaemia followed by waves of VSG-specific antibody. It is known that trypanotolerant N'Dama cattle infected with Trypanosoma congolense have significantly lower levels of parasitaemia than the more susceptible Boran cattle. It has been suggested that this reflects a more effective VSG-specific antibody response in the N'Damas. We have tested this hypothesis by examining VSG-specific antibody responses in N'Dama and Boran cattle during experimental infection with T. congolense. 1995 2010-12-09T11:11:59Z 2010-12-09T11:11:59Z Conference Paper https://hdl.handle.net/10568/2824 en Open Access International Laboratory for Research on Animal Diseases |
| spellingShingle | trypanosomes (phytomonas) infection immune response disease control animal diseases glossinidae glossina morsitans ndama cattle goats trypanosoma congolense Williams, D.J.L. Taylor, K. Newson, J. Naessens, Jan Authié, Edith Protective and inappropriate antibody responses in trypanosome-infected cattle |
| title | Protective and inappropriate antibody responses in trypanosome-infected cattle |
| title_full | Protective and inappropriate antibody responses in trypanosome-infected cattle |
| title_fullStr | Protective and inappropriate antibody responses in trypanosome-infected cattle |
| title_full_unstemmed | Protective and inappropriate antibody responses in trypanosome-infected cattle |
| title_short | Protective and inappropriate antibody responses in trypanosome-infected cattle |
| title_sort | protective and inappropriate antibody responses in trypanosome infected cattle |
| topic | trypanosomes (phytomonas) infection immune response disease control animal diseases glossinidae glossina morsitans ndama cattle goats trypanosoma congolense |
| url | https://hdl.handle.net/10568/2824 |
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