The MHC in bovine theileriosis
This paper presents a summary of the current knowledge on the MHC restriction of Theileria specific cytotoxic T cell responses and indicated how MHC phenotype may influence the parasite strain specificity of the response. The data presented were derived from studies of the response in vivo as well a...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
1988
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| Online Access: | https://hdl.handle.net/10568/28222 |
| _version_ | 1855522544470196224 |
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| author | Morrison, W. Ivan Goddeeris, Bruno M. Teale, A.J. |
| author_browse | Goddeeris, Bruno M. Morrison, W. Ivan Teale, A.J. |
| author_facet | Morrison, W. Ivan Goddeeris, Bruno M. Teale, A.J. |
| author_sort | Morrison, W. Ivan |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | This paper presents a summary of the current knowledge on the MHC restriction of Theileria specific cytotoxic T cell responses and indicated how MHC phenotype may influence the parasite strain specificity of the response. The data presented were derived from studies of the response in vivo as well as of cytotoxic T cell lines and clones established in vitro from immune cattle. Two antigenically different stocks of the parasite, namely T. parva (Muguga) and T. parva (Marikebuni), were used. Animals immunized with T. parva (Marikebuni) are protected against challenge with T. parva (Muguga), wheras a proportion of animals immunized with T. parva (Muguga) are susceptible to challenge with T. parva (Marikebuni). The results indicate that there is a hierarchy dominance among BoLA class I molecules in the restriction of the Theileria - specific cytotoxic T cell response. |
| format | Journal Article |
| id | CGSpace28222 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1988 |
| publishDateRange | 1988 |
| publishDateSort | 1988 |
| record_format | dspace |
| spelling | CGSpace282222024-01-17T12:58:34Z The MHC in bovine theileriosis Morrison, W. Ivan Goddeeris, Bruno M. Teale, A.J. cattle east coast fever bovine theileriosis toxicity This paper presents a summary of the current knowledge on the MHC restriction of Theileria specific cytotoxic T cell responses and indicated how MHC phenotype may influence the parasite strain specificity of the response. The data presented were derived from studies of the response in vivo as well as of cytotoxic T cell lines and clones established in vitro from immune cattle. Two antigenically different stocks of the parasite, namely T. parva (Muguga) and T. parva (Marikebuni), were used. Animals immunized with T. parva (Marikebuni) are protected against challenge with T. parva (Muguga), wheras a proportion of animals immunized with T. parva (Muguga) are susceptible to challenge with T. parva (Marikebuni). The results indicate that there is a hierarchy dominance among BoLA class I molecules in the restriction of the Theileria - specific cytotoxic T cell response. 1988 2013-05-06T07:00:10Z 2013-05-06T07:00:10Z Journal Article https://hdl.handle.net/10568/28222 en Limited Access Animal Genetics;19(Suppl. 1): 63-67 |
| spellingShingle | cattle east coast fever bovine theileriosis toxicity Morrison, W. Ivan Goddeeris, Bruno M. Teale, A.J. The MHC in bovine theileriosis |
| title | The MHC in bovine theileriosis |
| title_full | The MHC in bovine theileriosis |
| title_fullStr | The MHC in bovine theileriosis |
| title_full_unstemmed | The MHC in bovine theileriosis |
| title_short | The MHC in bovine theileriosis |
| title_sort | mhc in bovine theileriosis |
| topic | cattle east coast fever bovine theileriosis toxicity |
| url | https://hdl.handle.net/10568/28222 |
| work_keys_str_mv | AT morrisonwivan themhcinbovinetheileriosis AT goddeerisbrunom themhcinbovinetheileriosis AT tealeaj themhcinbovinetheileriosis AT morrisonwivan mhcinbovinetheileriosis AT goddeerisbrunom mhcinbovinetheileriosis AT tealeaj mhcinbovinetheileriosis |