Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle
Trypanosomes are covered with a dense layer of antigenically identical glycoproteins. These molecules are highly immunogenic and elicit an antibody response in the infected host. Antibodies against the surface-exposed epitopes of the trypanosome variable surface glycoproteins (VSG) mediate the destr...
| Main Authors: | , , , , |
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| Format: | Conference Proceedings |
| Language: | Inglés |
| Published: |
International Laboratory for Research on Animal Diseases
1994
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/2819 |
| _version_ | 1855516362338729984 |
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| author | Williams, D.J.L. Taylor, K. Wilkie, B. Gichuki, B. Authié, Edith |
| author_browse | Authié, Edith Gichuki, B. Taylor, K. Wilkie, B. Williams, D.J.L. |
| author_facet | Williams, D.J.L. Taylor, K. Wilkie, B. Gichuki, B. Authié, Edith |
| author_sort | Williams, D.J.L. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Trypanosomes are covered with a dense layer of antigenically identical glycoproteins. These molecules are highly immunogenic and elicit an antibody response in the infected host. Antibodies against the surface-exposed epitopes of the trypanosome variable surface glycoproteins (VSG) mediate the destruction and clearance of trypanosomes expressing that particular VSG. As those parasites are cleared, they are replaced by others expressing antigenically different VSG molecules. Again, an antibody response is generated. Thus trypanosome infections are characterized by waves of parasites followed by waves of VSG-specific antibody. It has been shown that trypanotolerant N'Dama cattle infected with trypanosoma congolense have significantly lower levels of parasitaemia than more susceptible Boran cattle. It has been postulated that the lower parasitaemia is the result of a more effective antibody reponse against the VSG-specific antibody responses in N'Dama and Boran cattle during an experimental T. congolense infection. |
| format | Conference Proceedings |
| id | CGSpace2819 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1994 |
| publishDateRange | 1994 |
| publishDateSort | 1994 |
| publisher | International Laboratory for Research on Animal Diseases |
| publisherStr | International Laboratory for Research on Animal Diseases |
| record_format | dspace |
| spelling | CGSpace28192024-03-06T10:16:43Z Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle Williams, D.J.L. Taylor, K. Wilkie, B. Gichuki, B. Authié, Edith trypanosomiasis glycoprotein ndama cattle immune response disease control animal diseases Trypanosomes are covered with a dense layer of antigenically identical glycoproteins. These molecules are highly immunogenic and elicit an antibody response in the infected host. Antibodies against the surface-exposed epitopes of the trypanosome variable surface glycoproteins (VSG) mediate the destruction and clearance of trypanosomes expressing that particular VSG. As those parasites are cleared, they are replaced by others expressing antigenically different VSG molecules. Again, an antibody response is generated. Thus trypanosome infections are characterized by waves of parasites followed by waves of VSG-specific antibody. It has been shown that trypanotolerant N'Dama cattle infected with trypanosoma congolense have significantly lower levels of parasitaemia than more susceptible Boran cattle. It has been postulated that the lower parasitaemia is the result of a more effective antibody reponse against the VSG-specific antibody responses in N'Dama and Boran cattle during an experimental T. congolense infection. 1994 2010-12-09T11:11:29Z 2010-12-09T11:11:29Z Conference Proceedings https://hdl.handle.net/10568/2819 en Open Access International Laboratory for Research on Animal Diseases |
| spellingShingle | trypanosomiasis glycoprotein ndama cattle immune response disease control animal diseases Williams, D.J.L. Taylor, K. Wilkie, B. Gichuki, B. Authié, Edith Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle |
| title | Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle |
| title_full | Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle |
| title_fullStr | Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle |
| title_full_unstemmed | Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle |
| title_short | Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle |
| title_sort | antibody responses to the surface exposed epitopes of the trypanosome variable surface glycoprotein in n dama and boran cattle |
| topic | trypanosomiasis glycoprotein ndama cattle immune response disease control animal diseases |
| url | https://hdl.handle.net/10568/2819 |
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