Reduced responsiveness of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense
The response of the pituitary-adrenal axis to corticotrophin-releasing hormone (CRH) and the adrenal response to adrenocorticotrophin hormone (ACTH) stimulation were studied during infection of Boran (Bos indicus) cattle with Trypanosoma congolense. For CRH, 15 animals were challenged during pre-inf...
| Autores principales: | , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
1993
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/27966 |
| _version_ | 1855520446268571648 |
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| author | Abebe, G. Eley, R.M. Ole-MoiYoi, O.K. |
| author_browse | Abebe, G. Eley, R.M. Ole-MoiYoi, O.K. |
| author_facet | Abebe, G. Eley, R.M. Ole-MoiYoi, O.K. |
| author_sort | Abebe, G. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The response of the pituitary-adrenal axis to corticotrophin-releasing hormone (CRH) and the adrenal response to adrenocorticotrophin hormone (ACTH) stimulation were studied during infection of Boran (Bos indicus) cattle with Trypanosoma congolense. For CRH, 15 animals were challenged during pre-infection and infection phases, while for ACTH 10 animals were challenged during pre-infection, infection and post-treatment phases of the experiments. The axis showed a reduced responsiveness after CRH challenge during patent parasitaemia, manifested by low (p<0.05) plasma ACTH and cortisol concentration as compared to the pre-infection CRH challenge concentrations. Cortisol concentration after ACTH challenge during pre-infection, infection and post-treatment phases did not differ. The reduced pituitary-adrenal response to CRH challenge and the normal adrenal response to ACTH challenge found during trypanosomiasis indicates pituitary dysfunction due to infection. |
| format | Journal Article |
| id | CGSpace27966 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1993 |
| publishDateRange | 1993 |
| publishDateSort | 1993 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace279662024-05-01T08:16:14Z Reduced responsiveness of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense Abebe, G. Eley, R.M. Ole-MoiYoi, O.K. trypanosoma congolense infection The response of the pituitary-adrenal axis to corticotrophin-releasing hormone (CRH) and the adrenal response to adrenocorticotrophin hormone (ACTH) stimulation were studied during infection of Boran (Bos indicus) cattle with Trypanosoma congolense. For CRH, 15 animals were challenged during pre-infection and infection phases, while for ACTH 10 animals were challenged during pre-infection, infection and post-treatment phases of the experiments. The axis showed a reduced responsiveness after CRH challenge during patent parasitaemia, manifested by low (p<0.05) plasma ACTH and cortisol concentration as compared to the pre-infection CRH challenge concentrations. Cortisol concentration after ACTH challenge during pre-infection, infection and post-treatment phases did not differ. The reduced pituitary-adrenal response to CRH challenge and the normal adrenal response to ACTH challenge found during trypanosomiasis indicates pituitary dysfunction due to infection. 1993-07 2013-05-06T06:59:38Z 2013-05-06T06:59:38Z Journal Article https://hdl.handle.net/10568/27966 en Limited Access Oxford University Press Acta Endocrinologica;129: 75-80 |
| spellingShingle | trypanosoma congolense infection Abebe, G. Eley, R.M. Ole-MoiYoi, O.K. Reduced responsiveness of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense |
| title | Reduced responsiveness of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense |
| title_full | Reduced responsiveness of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense |
| title_fullStr | Reduced responsiveness of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense |
| title_full_unstemmed | Reduced responsiveness of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense |
| title_short | Reduced responsiveness of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense |
| title_sort | reduced responsiveness of the hypothalamic pituitary adrenal axis in boran bos indicus cattle infected with trypanosoma congolense |
| topic | trypanosoma congolense infection |
| url | https://hdl.handle.net/10568/27966 |
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