Markers for mapping trypanotolerance genes
Several West African Bos taurus cattle breeds show a remarkable ability to survive and be productive in the face of a trypanosome challenge which would quickly kill susceptible cattle. This phenomenon, termed trypanotolerance, offers a sustainable approach to improving cattle productivity in the ts...
| Main Authors: | , |
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| Format: | Conference Paper |
| Language: | Inglés |
| Published: |
International Laboratory for Research on Animal Diseases
1994
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/2796 |
| _version_ | 1855526900243365888 |
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| author | Kemp, Stephen J. Teale, A.J. |
| author_browse | Kemp, Stephen J. Teale, A.J. |
| author_facet | Kemp, Stephen J. Teale, A.J. |
| author_sort | Kemp, Stephen J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Several West African Bos taurus cattle breeds show a remarkable ability to survive and be productive in the face of a trypanosome challenge which would quickly kill susceptible cattle. This phenomenon, termed trypanotolerance, offers a sustainable approach to improving cattle productivity in the tsetse-infested areas of Africa. The best charaterized of the trypanotolerant breeds is the N'Dama. A genome analysis approach is adopted in an attempt to identify analysis approach is adopted in an attempt to identify the genetic basis for trypanotolerance in the N'Dama. A cross between N'Dama and trypanosusceptible Boran (B. indicus) has been established using embryo-transfer to generate large full-sibling families. The F1 generation is almost complete and 14F2 calves were boran by April 1993. These will be challenged with several other laboratories, they will be genotyped with a large array of genetic markers. Correlations will then be sought between marker inheritance and trypanotolerance status. These markers fall into three main categories. 1. Randomly amplified DNA polymorphisms. 2. Randomly identified polymorphic dinucleotide repeat sequence (microsatellites). 3. Polymorphisms in specific genes. |
| format | Conference Paper |
| id | CGSpace2796 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1994 |
| publishDateRange | 1994 |
| publishDateSort | 1994 |
| publisher | International Laboratory for Research on Animal Diseases |
| publisherStr | International Laboratory for Research on Animal Diseases |
| record_format | dspace |
| spelling | CGSpace27962023-12-21T14:51:35Z Markers for mapping trypanotolerance genes Kemp, Stephen J. Teale, A.J. trypanotolerance animal diseases genes genetic markers genetic maps Several West African Bos taurus cattle breeds show a remarkable ability to survive and be productive in the face of a trypanosome challenge which would quickly kill susceptible cattle. This phenomenon, termed trypanotolerance, offers a sustainable approach to improving cattle productivity in the tsetse-infested areas of Africa. The best charaterized of the trypanotolerant breeds is the N'Dama. A genome analysis approach is adopted in an attempt to identify analysis approach is adopted in an attempt to identify the genetic basis for trypanotolerance in the N'Dama. A cross between N'Dama and trypanosusceptible Boran (B. indicus) has been established using embryo-transfer to generate large full-sibling families. The F1 generation is almost complete and 14F2 calves were boran by April 1993. These will be challenged with several other laboratories, they will be genotyped with a large array of genetic markers. Correlations will then be sought between marker inheritance and trypanotolerance status. These markers fall into three main categories. 1. Randomly amplified DNA polymorphisms. 2. Randomly identified polymorphic dinucleotide repeat sequence (microsatellites). 3. Polymorphisms in specific genes. 1994 2010-12-09T11:10:49Z 2010-12-09T11:10:49Z Conference Paper https://hdl.handle.net/10568/2796 en Open Access International Laboratory for Research on Animal Diseases |
| spellingShingle | trypanotolerance animal diseases genes genetic markers genetic maps Kemp, Stephen J. Teale, A.J. Markers for mapping trypanotolerance genes |
| title | Markers for mapping trypanotolerance genes |
| title_full | Markers for mapping trypanotolerance genes |
| title_fullStr | Markers for mapping trypanotolerance genes |
| title_full_unstemmed | Markers for mapping trypanotolerance genes |
| title_short | Markers for mapping trypanotolerance genes |
| title_sort | markers for mapping trypanotolerance genes |
| topic | trypanotolerance animal diseases genes genetic markers genetic maps |
| url | https://hdl.handle.net/10568/2796 |
| work_keys_str_mv | AT kempstephenj markersformappingtrypanotolerancegenes AT tealeaj markersformappingtrypanotolerancegenes |