Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells
Ixodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs had...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Wiley
2005
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/21174 |
| _version_ | 1855527991203856384 |
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| author | Lambson, B. Nene, Vishvanath M. Obura, M. Shah, Tushaar Pandit, P. Ole-MoiYoi, O.K. Delroux, K. Welburn, S.C. Skilton, Robert A. Villiers, Etienne P. de Bishop, Richard P. |
| author_browse | Bishop, Richard P. Delroux, K. Lambson, B. Nene, Vishvanath M. Obura, M. Ole-MoiYoi, O.K. Pandit, P. Shah, Tushaar Skilton, Robert A. Villiers, Etienne P. de Welburn, S.C. |
| author_facet | Lambson, B. Nene, Vishvanath M. Obura, M. Shah, Tushaar Pandit, P. Ole-MoiYoi, O.K. Delroux, K. Welburn, S.C. Skilton, Robert A. Villiers, Etienne P. de Bishop, Richard P. |
| author_sort | Lambson, B. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Ixodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs had significant identity (< 1e-15) to previously identified sequences. Polypeptides that may interact with host pathways included a kinase inhibitor. Two proteins encoded homologues of the yolk protein vitellogenin and seventeen contained glycine-rich motifs. Four proteins without sequence matches had conserved structural folds, identified using a Threading algorithm. Predicted secretion signals were between fifteen and fifty-seven amino acids long. Four homologous polymorphic proteins contained conserved (26/27 residues) signal peptides. Ten functional tick secretion signals could not be unambiguously identified using predictive algorithms. |
| format | Journal Article |
| id | CGSpace21174 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace211742025-06-13T04:20:15Z Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells Lambson, B. Nene, Vishvanath M. Obura, M. Shah, Tushaar Pandit, P. Ole-MoiYoi, O.K. Delroux, K. Welburn, S.C. Skilton, Robert A. Villiers, Etienne P. de Bishop, Richard P. insects ticks ixodidae metastigmata salivary glands [exocrine glands] secretion mammals cells dna rhipicephalus appendiculatus nucleotide sequence amblyomma variegatum polymorphism proteins Ixodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs had significant identity (< 1e-15) to previously identified sequences. Polypeptides that may interact with host pathways included a kinase inhibitor. Two proteins encoded homologues of the yolk protein vitellogenin and seventeen contained glycine-rich motifs. Four proteins without sequence matches had conserved structural folds, identified using a Threading algorithm. Predicted secretion signals were between fifteen and fifty-seven amino acids long. Four homologous polymorphic proteins contained conserved (26/27 residues) signal peptides. Ten functional tick secretion signals could not be unambiguously identified using predictive algorithms. 2005-08 2012-07-09T05:47:05Z 2012-07-09T05:47:05Z Journal Article https://hdl.handle.net/10568/21174 en Limited Access Wiley Lambson, B., Nene, V., Obura, M., Shah, T., Pandit, P., Ole‐MoiYoi, O., Delroux, K., Welburn, S., Skilton, R., De Villiers, E., & Bishop, R. (2005). Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells. Insect Molecular Biology, 14(4), 403–414. Portico. https://doi.org/10.1111/j.1365-2583.2005.00571.x |
| spellingShingle | insects ticks ixodidae metastigmata salivary glands [exocrine glands] secretion mammals cells dna rhipicephalus appendiculatus nucleotide sequence amblyomma variegatum polymorphism proteins Lambson, B. Nene, Vishvanath M. Obura, M. Shah, Tushaar Pandit, P. Ole-MoiYoi, O.K. Delroux, K. Welburn, S.C. Skilton, Robert A. Villiers, Etienne P. de Bishop, Richard P. Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells |
| title | Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells |
| title_full | Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells |
| title_fullStr | Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells |
| title_full_unstemmed | Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells |
| title_short | Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells |
| title_sort | identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells |
| topic | insects ticks ixodidae metastigmata salivary glands [exocrine glands] secretion mammals cells dna rhipicephalus appendiculatus nucleotide sequence amblyomma variegatum polymorphism proteins |
| url | https://hdl.handle.net/10568/21174 |
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