Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle
Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and tr...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
National Academy of Sciences
2003
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/1870 |
| _version_ | 1855529419153604608 |
|---|---|
| author | Hanotte, Olivier H. Ronin, Y. Agaba, Morris Nilsson, P. Gelhaus, A. Horstmann, R. Sugimoto, Y. Kemp, Stephen J. Gibson, John P. Korol, A. Soller, M. Teale, A.J. |
| author_browse | Agaba, Morris Gelhaus, A. Gibson, John P. Hanotte, Olivier H. Horstmann, R. Kemp, Stephen J. Korol, A. Nilsson, P. Ronin, Y. Soller, M. Sugimoto, Y. Teale, A.J. |
| author_facet | Hanotte, Olivier H. Ronin, Y. Agaba, Morris Nilsson, P. Gelhaus, A. Horstmann, R. Sugimoto, Y. Kemp, Stephen J. Gibson, John P. Korol, A. Soller, M. Teale, A.J. |
| author_sort | Hanotte, Olivier H. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and trypanosusceptible improved Kenya Boran (Bos indicus) cattle. Sixteen phenotypic traits were defined describing anemia, body weight, and parasitemia. One hundred seventy-seven F2 animals and their parents and grandparents were genotyped at 477 molecular marker loci covering all 29 cattle autosomes. Total genome coverage was 82%. Putative QTL were mapped to 18 autosomes at a genomewise false discovery rate of <0.20. The results are consistent with a single QTL on 17 chromosomes and two QTL on BTA16. Individual QTL effects ranged from ≈6% to 20% of the phenotypic variance of the trait. Excluding chromosomes with ambiguous or nontrypanotolerance effects, the allele for resistance to trypanosomosis originated from the N'Dama parent at nine QTL and from the Kenya Boran at five QTL, and at four QTL there is evidence of an overdominant mode of inheritance. These results suggest that selection for trypanotolerance within an F2 cross between N'Dama and Boran cattle could produce a synthetic breed with higher trypanotolerance levels than currently exist in the parental breeds. |
| format | Journal Article |
| id | CGSpace1870 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2003 |
| publishDateRange | 2003 |
| publishDateSort | 2003 |
| publisher | National Academy of Sciences |
| publisherStr | National Academy of Sciences |
| record_format | dspace |
| spelling | CGSpace18702024-10-17T09:47:53Z Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle Hanotte, Olivier H. Ronin, Y. Agaba, Morris Nilsson, P. Gelhaus, A. Horstmann, R. Sugimoto, Y. Kemp, Stephen J. Gibson, John P. Korol, A. Soller, M. Teale, A.J. trypanosomosis cattle Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and trypanosusceptible improved Kenya Boran (Bos indicus) cattle. Sixteen phenotypic traits were defined describing anemia, body weight, and parasitemia. One hundred seventy-seven F2 animals and their parents and grandparents were genotyped at 477 molecular marker loci covering all 29 cattle autosomes. Total genome coverage was 82%. Putative QTL were mapped to 18 autosomes at a genomewise false discovery rate of <0.20. The results are consistent with a single QTL on 17 chromosomes and two QTL on BTA16. Individual QTL effects ranged from ≈6% to 20% of the phenotypic variance of the trait. Excluding chromosomes with ambiguous or nontrypanotolerance effects, the allele for resistance to trypanosomosis originated from the N'Dama parent at nine QTL and from the Kenya Boran at five QTL, and at four QTL there is evidence of an overdominant mode of inheritance. These results suggest that selection for trypanotolerance within an F2 cross between N'Dama and Boran cattle could produce a synthetic breed with higher trypanotolerance levels than currently exist in the parental breeds. 2003-06-24 2010-06-13T16:10:53Z 2010-06-13T16:10:53Z Journal Article https://hdl.handle.net/10568/1870 en Open Access National Academy of Sciences Hanotte, O.; Ronin, Y.; Agaba, M.; Nilsson, P.; Gelhaus, A.; Horstmann, R.; Sugimoto, Y.; Kemp, S.; Gibson, J.; Korol, A.; Soller, M.; Teale, A. 2003. Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle. PNAS 100(13):7443-7448. |
| spellingShingle | trypanosomosis cattle Hanotte, Olivier H. Ronin, Y. Agaba, Morris Nilsson, P. Gelhaus, A. Horstmann, R. Sugimoto, Y. Kemp, Stephen J. Gibson, John P. Korol, A. Soller, M. Teale, A.J. Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle |
| title | Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle |
| title_full | Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle |
| title_fullStr | Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle |
| title_full_unstemmed | Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle |
| title_short | Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle |
| title_sort | mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant west african n dama and susceptible east african boran cattle |
| topic | trypanosomosis cattle |
| url | https://hdl.handle.net/10568/1870 |
| work_keys_str_mv | AT hanotteolivierh mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT roniny mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT agabamorris mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT nilssonp mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT gelhausa mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT horstmannr mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT sugimotoy mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT kempstephenj mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT gibsonjohnp mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT korola mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT sollerm mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle AT tealeaj mappingofquantitativetraitlocicontrollingtrypanotoleranceinacrossoftolerantwestafricanndamaandsusceptibleeastafricanborancattle |