| Summary: | In 2023, WHO released a guideline on prevention and management of wasting and nutritional oedema (acute malnutrition) in infants and children under 5 years as part of the Global Action Plan on Child Wasting, a consolidated framework to accelerate progress in prevention and management of wasting and nutritional oedema.
There were evidence gaps across the populations and topics, which made it difficult for the Guideline Development Group to make recommendations for all prioritised guideline questions and interventions of interest.
The challenges during the guideline development process linked to these evidence gaps included a lack of direct evidence to answer complex guideline questions such as which children should be prioritised for interventions.
In this supplement, we share evidence gaps relevant to the guideline questions for the respective populations and topics, research and methods considerations for resource use and cost-effectiveness data, key reflections on processes and methods for developing the WHO guideline, and development of core outcome sets for future research on wasting and nutritional oedema.
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