Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi
Diverse salmonellae have the potential to cause disease and may be carried asymptomatically within the intestine of many vertebrate species. The relative contribution of human, animal, and environmental hosts to the transmission of <i>Salmonella</i> is unknown within and between households in low-in...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Nature Research
2025
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/177904 |
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| author | Wilson, C.N. Musicha, P. Beale, M.A. Diness, Y. Kanjerwa, O. Salifu, C. Katuah, Z. Duncan, P. Nyangu, J. Mungu, A. Deleza, M. Banda, L. Makhaza, L. Elviss, N. Jewell, C.P. Pinchbeck, G. Feasey, N.A. Fèvre, Eric M. Thomson, N.R. |
| author_browse | Banda, L. Beale, M.A. Deleza, M. Diness, Y. Duncan, P. Elviss, N. Feasey, N.A. Fèvre, Eric M. Jewell, C.P. Kanjerwa, O. Katuah, Z. Makhaza, L. Mungu, A. Musicha, P. Nyangu, J. Pinchbeck, G. Salifu, C. Thomson, N.R. Wilson, C.N. |
| author_facet | Wilson, C.N. Musicha, P. Beale, M.A. Diness, Y. Kanjerwa, O. Salifu, C. Katuah, Z. Duncan, P. Nyangu, J. Mungu, A. Deleza, M. Banda, L. Makhaza, L. Elviss, N. Jewell, C.P. Pinchbeck, G. Feasey, N.A. Fèvre, Eric M. Thomson, N.R. |
| author_sort | Wilson, C.N. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Diverse salmonellae have the potential to cause disease and may be carried asymptomatically within the intestine of many vertebrate species. The relative contribution of human, animal, and environmental hosts to the transmission of <i>Salmonella</i> is unknown within and between households in low-income settings, especially where humans and animals may live in close contact and sanitary infrastructure is often inadequate. Between November 2018 and December 2019, we isolated <i>Salmonella</i> spp. from thirty households in urban and rural locations in Malawi, sampling at three time points from the stool of humans, animals, and their household environment. Using whole genome sequencing and fine-resolution bioinformatic and phylogenetic analyses we found evidence of sharing of <i>Salmonella</i> species and strains between humans, animals and the environment, both within and between households. The intricate web of interconnected salmonellae within this ecosystem underscores the importance of adopting a multi-faceted ‘One Health’ strategy when considering control of <i>Salmonella</i> in low-intensity agricultural systems. |
| format | Journal Article |
| id | CGSpace177904 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Nature Research |
| publisherStr | Nature Research |
| record_format | dspace |
| spelling | CGSpace1779042025-11-14T07:24:54Z Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi Wilson, C.N. Musicha, P. Beale, M.A. Diness, Y. Kanjerwa, O. Salifu, C. Katuah, Z. Duncan, P. Nyangu, J. Mungu, A. Deleza, M. Banda, L. Makhaza, L. Elviss, N. Jewell, C.P. Pinchbeck, G. Feasey, N.A. Fèvre, Eric M. Thomson, N.R. one health approach zoonoses Diverse salmonellae have the potential to cause disease and may be carried asymptomatically within the intestine of many vertebrate species. The relative contribution of human, animal, and environmental hosts to the transmission of <i>Salmonella</i> is unknown within and between households in low-income settings, especially where humans and animals may live in close contact and sanitary infrastructure is often inadequate. Between November 2018 and December 2019, we isolated <i>Salmonella</i> spp. from thirty households in urban and rural locations in Malawi, sampling at three time points from the stool of humans, animals, and their household environment. Using whole genome sequencing and fine-resolution bioinformatic and phylogenetic analyses we found evidence of sharing of <i>Salmonella</i> species and strains between humans, animals and the environment, both within and between households. The intricate web of interconnected salmonellae within this ecosystem underscores the importance of adopting a multi-faceted ‘One Health’ strategy when considering control of <i>Salmonella</i> in low-intensity agricultural systems. 2025-11-12 2025-11-14T06:16:23Z 2025-11-14T06:16:23Z Journal Article https://hdl.handle.net/10568/177904 en Open Access Nature Research Wilson, C.N., Musicha, P., Beale, M.A., Diness, Y., Kanjerwa, O., Salifu, C., Katuah, Z., Duncan, P., Nyangu, J., Mungu, A., Deleza, M., Banda, L., Makhaza, L., Elviss, N., Jewell, C.P., Pinchbeck, G., Feasey, N.A., Fèvre, E.M. and Thomson, N.R. 2025. Circulation of <i>Salmonella</i> spp. between humans, animals and the environment in animal-owning households in Malawi. Nature Communications 16: 9703. |
| spellingShingle | one health approach zoonoses Wilson, C.N. Musicha, P. Beale, M.A. Diness, Y. Kanjerwa, O. Salifu, C. Katuah, Z. Duncan, P. Nyangu, J. Mungu, A. Deleza, M. Banda, L. Makhaza, L. Elviss, N. Jewell, C.P. Pinchbeck, G. Feasey, N.A. Fèvre, Eric M. Thomson, N.R. Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi |
| title | Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi |
| title_full | Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi |
| title_fullStr | Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi |
| title_full_unstemmed | Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi |
| title_short | Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi |
| title_sort | circulation of salmonella spp between humans animals and the environment in animal owning households in malawi |
| topic | one health approach zoonoses |
| url | https://hdl.handle.net/10568/177904 |
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