| Summary: | Fertilization is a crucial aspect of soil management aimed at regulating the nutrient cycle and availability and supporting plant growth and increasing productivity. It involves the application of nutrients, either to the soil [1] or to plant foliage [2] to replenish optimal content in the soil and, ultimately, in the plants. Fertilization has always been an integral part of agricultural production, and its origins can be traced back to around 8000 BCE [3]. Over time the use of fertilizers has evolved, and application rates have significantly increased thanks to industrial processes [4] that enabled the production of low-priced and accessible synthetic fertilizers. Figure 1 shows the extent of the worldwide use of nitrogen-based fertilizers, the most typical nutrient applied in agriculture as it is often a yield-limiting nutrient.
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