Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso
Background Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease, such as offspring telomere length (TL) and mitochondrial DNA content (mtDNAc) is unknown. Objectives We assessed t...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Tsinghua University Press Ltd.
2025
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/177135 |
| _version_ | 1855516439090298880 |
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| author | Hanley-Cook, Giles T. Bastos-Moreira, Yuri Martens, Dries S. Dailey-Chwalibóg, Trenton Toe, Laeticia Celine de Kok, Brenda Ouédraogo, Lionel OIivier Argaw, Alemayehu Tesfamariam, Kokeb Kolsteren, Patrick Huybregts, Lieven Nawrot, Tim S. De Saeger, Sarah De Boevre, Marthe Lachat, Carl |
| author_browse | Argaw, Alemayehu Bastos-Moreira, Yuri Dailey-Chwalibóg, Trenton De Boevre, Marthe De Saeger, Sarah Hanley-Cook, Giles T. Huybregts, Lieven Kolsteren, Patrick Lachat, Carl Martens, Dries S. Nawrot, Tim S. Ouédraogo, Lionel OIivier Tesfamariam, Kokeb Toe, Laeticia Celine de Kok, Brenda |
| author_facet | Hanley-Cook, Giles T. Bastos-Moreira, Yuri Martens, Dries S. Dailey-Chwalibóg, Trenton Toe, Laeticia Celine de Kok, Brenda Ouédraogo, Lionel OIivier Argaw, Alemayehu Tesfamariam, Kokeb Kolsteren, Patrick Huybregts, Lieven Nawrot, Tim S. De Saeger, Sarah De Boevre, Marthe Lachat, Carl |
| author_sort | Hanley-Cook, Giles T. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background
Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease, such as offspring telomere length (TL) and mitochondrial DNA content (mtDNAc) is unknown.
Objectives
We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome.
Design
We conducted a randomized controlled trial in rural Burkina Faso, among pregnant females (15-40 years old) enrolled at < 21 weeks of gestation. Mothers received either MMN-fortified BEP and IFA (intervention) or IFA only (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants, respectively. Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess TL and mtDNAc differences across trial arms.
Results
We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL [β =-0.010 (95% CI:-0.057, 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI:-0.203, 0.073); P = 0.354], as compared to an IFA tablet alone. These findings were confirmed (P > 0.05) by adjusting the regression models for potential prognostic factors of study outcomes at enrollment. Exploratory analyses indicated higher, but non-significantly different mtDNAc among children born either small-for-gestational age, low birthweight, or preterm.
Conclusion
Newborns from mothers who received daily nutritional supplements across gestation did not have different relative TL or mtDNAc. |
| format | Journal Article |
| id | CGSpace177135 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Tsinghua University Press Ltd. |
| publisherStr | Tsinghua University Press Ltd. |
| record_format | dspace |
| spelling | CGSpace1771352025-12-08T09:54:28Z Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso Hanley-Cook, Giles T. Bastos-Moreira, Yuri Martens, Dries S. Dailey-Chwalibóg, Trenton Toe, Laeticia Celine de Kok, Brenda Ouédraogo, Lionel OIivier Argaw, Alemayehu Tesfamariam, Kokeb Kolsteren, Patrick Huybregts, Lieven Nawrot, Tim S. De Saeger, Sarah De Boevre, Marthe Lachat, Carl perinatal period trace elements supplements telomeres mitochondrial DNA health genetic markers Background Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. The effect on markers of health and disease, such as offspring telomere length (TL) and mitochondrial DNA content (mtDNAc) is unknown. Objectives We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn TL as a secondary outcome and mtDNAc as a non-declared outcome. Design We conducted a randomized controlled trial in rural Burkina Faso, among pregnant females (15-40 years old) enrolled at < 21 weeks of gestation. Mothers received either MMN-fortified BEP and IFA (intervention) or IFA only (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants, respectively. Average relative TL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess TL and mtDNAc differences across trial arms. Results We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn TL [β =-0.010 (95% CI:-0.057, 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI:-0.203, 0.073); P = 0.354], as compared to an IFA tablet alone. These findings were confirmed (P > 0.05) by adjusting the regression models for potential prognostic factors of study outcomes at enrollment. Exploratory analyses indicated higher, but non-significantly different mtDNAc among children born either small-for-gestational age, low birthweight, or preterm. Conclusion Newborns from mothers who received daily nutritional supplements across gestation did not have different relative TL or mtDNAc. 2025-04 2025-10-15T19:52:52Z 2025-10-15T19:52:52Z Journal Article https://hdl.handle.net/10568/177135 en https://doi.org/10.1371/journal.pmed.1004242 https://doi.org/10.1371/journal.pmed.1004186 https://doi.org/10.1093/jn/nxac171 https://doi.org/10.1093/jn/nxac104 https://doi.org/10.1093/jn/nxab289 https://doi.org/10.1038/s41467-025-57838-y Open Access Tsinghua University Press Ltd. Hanley-Cook, Giles T.; Bastos-Moreira, Yuri; Martens, Dries S.; Dailey-Chwalibóg, Trenton; Toe, Laeticia Celine; de Kok, Brenda; et al. 2025. Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso. Food Science and Human Wellness 14(4): 9250304. https://doi.org/10.26599/FSHW.2024.9250304 |
| spellingShingle | perinatal period trace elements supplements telomeres mitochondrial DNA health genetic markers Hanley-Cook, Giles T. Bastos-Moreira, Yuri Martens, Dries S. Dailey-Chwalibóg, Trenton Toe, Laeticia Celine de Kok, Brenda Ouédraogo, Lionel OIivier Argaw, Alemayehu Tesfamariam, Kokeb Kolsteren, Patrick Huybregts, Lieven Nawrot, Tim S. De Saeger, Sarah De Boevre, Marthe Lachat, Carl Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso |
| title | Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso |
| title_full | Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso |
| title_fullStr | Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso |
| title_full_unstemmed | Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso |
| title_short | Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso |
| title_sort | prenatal multiple micronutrient fortified balanced energy protein supplementation and newborn telomere length and mitochondrial dna content a randomized controlled efficacy trial in rural burkina faso |
| topic | perinatal period trace elements supplements telomeres mitochondrial DNA health genetic markers |
| url | https://hdl.handle.net/10568/177135 |
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