Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk
Hyperuricemia (HUA) has become the fourth most important health-threatening risk factor after hypertension, hyperglycemia, and hyperlipidemia, but the efficacy of existing uric acid-lowering treatments (ULT) is poor, and there is an urgent need to explore novel ULT strategies. <i>Akkermansia mucinip...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
American Society for Microbiology
2025
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/176273 |
| _version_ | 1855540092035137536 |
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| author | Fu, Y. Chen, J. Cao, Q. Zhu, S. Chen, W. Luo, H. Zhao, Y. Lukuyu, Ben A. Wang, X. Tu, Q. Zhang, Y. Jiang, X. Yang, L. Wang, W. |
| author_browse | Cao, Q. Chen, J. Chen, W. Fu, Y. Jiang, X. Lukuyu, Ben A. Luo, H. Tu, Q. Wang, W. Wang, X. Yang, L. Zhang, Y. Zhao, Y. Zhu, S. |
| author_facet | Fu, Y. Chen, J. Cao, Q. Zhu, S. Chen, W. Luo, H. Zhao, Y. Lukuyu, Ben A. Wang, X. Tu, Q. Zhang, Y. Jiang, X. Yang, L. Wang, W. |
| author_sort | Fu, Y. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Hyperuricemia (HUA) has become the fourth most important health-threatening risk factor after hypertension, hyperglycemia, and hyperlipidemia, but the efficacy of existing uric acid-lowering treatments (ULT) is poor, and there is an urgent need to explore novel ULT strategies. <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>), a next-generation probiotic, shows promise in promoting intestinal homeostasis and metabolic regulation. Previous studies have demonstrated the potential application of <i>A. muciniphila</i> in ULT, but its specific mechanism has not been elucidated. In this study, we isolated a strain of <i>A. muciniphila</i>, named K101, from the cecum of goslings. In vitro experiments showed that K101 directly degrades uric acid, suggesting a potential microbial-metabolic crosstalk mechanism for anti-HUA. In vivo experiments showed that K101 increased the abundance of uric acid metabolism-related microbiota, such as <i>A. muciniphila</i> and <i>Lactobacillus</i>. Functionally, K101 synergistically promoted uric acid excretion by activating the intestinal excretory protein ABCG2 and inhibiting the renal uric acid reabsorption protein GLUT9. In addition, K101 provides a stable environment for uric acid metabolism by inhibiting renal inflammatory responses. Overall, <i>A. muciniphila</i> K101 exerts anti-HUA effects by remodeling the intestinal microbiota and excretion of uric acid through the gut-renal axis. This study offers new insights into microbial-metabolic crosstalk in uric acid metabolism in <i>A. muciniphila</i> and identifies potential targets for gout prevention and ULT strategy development. |
| format | Journal Article |
| id | CGSpace176273 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | American Society for Microbiology |
| publisherStr | American Society for Microbiology |
| record_format | dspace |
| spelling | CGSpace1762732025-09-24T07:51:26Z Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk Fu, Y. Chen, J. Cao, Q. Zhu, S. Chen, W. Luo, H. Zhao, Y. Lukuyu, Ben A. Wang, X. Tu, Q. Zhang, Y. Jiang, X. Yang, L. Wang, W. geese poultry Hyperuricemia (HUA) has become the fourth most important health-threatening risk factor after hypertension, hyperglycemia, and hyperlipidemia, but the efficacy of existing uric acid-lowering treatments (ULT) is poor, and there is an urgent need to explore novel ULT strategies. <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>), a next-generation probiotic, shows promise in promoting intestinal homeostasis and metabolic regulation. Previous studies have demonstrated the potential application of <i>A. muciniphila</i> in ULT, but its specific mechanism has not been elucidated. In this study, we isolated a strain of <i>A. muciniphila</i>, named K101, from the cecum of goslings. In vitro experiments showed that K101 directly degrades uric acid, suggesting a potential microbial-metabolic crosstalk mechanism for anti-HUA. In vivo experiments showed that K101 increased the abundance of uric acid metabolism-related microbiota, such as <i>A. muciniphila</i> and <i>Lactobacillus</i>. Functionally, K101 synergistically promoted uric acid excretion by activating the intestinal excretory protein ABCG2 and inhibiting the renal uric acid reabsorption protein GLUT9. In addition, K101 provides a stable environment for uric acid metabolism by inhibiting renal inflammatory responses. Overall, <i>A. muciniphila</i> K101 exerts anti-HUA effects by remodeling the intestinal microbiota and excretion of uric acid through the gut-renal axis. This study offers new insights into microbial-metabolic crosstalk in uric acid metabolism in <i>A. muciniphila</i> and identifies potential targets for gout prevention and ULT strategy development. 2025-09-23 2025-09-01T09:21:23Z 2025-09-01T09:21:23Z Journal Article https://hdl.handle.net/10568/176273 en Open Access American Society for Microbiology Fu, Y., Chen, J., Cao, Q., Zhu, S., Chen, W., Luo, H., Zhao, Y., Lukuyu, B.A., Wang, X., Tu, Q., Zhang, Y., Jiang, X., Yang, L. and Wang, W. 2025. Gut-kidney axis modulation by viable and inactivated <i>Akkermansia muciniphila</i> mitigates avian hyperuricemia through microbial-metabolic crosstalk. mSystems 10(9): e00773-25. |
| spellingShingle | geese poultry Fu, Y. Chen, J. Cao, Q. Zhu, S. Chen, W. Luo, H. Zhao, Y. Lukuyu, Ben A. Wang, X. Tu, Q. Zhang, Y. Jiang, X. Yang, L. Wang, W. Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk |
| title | Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk |
| title_full | Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk |
| title_fullStr | Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk |
| title_full_unstemmed | Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk |
| title_short | Gut-kidney axis modulation by viable and inactivated Akkermansia muciniphila mitigates avian hyperuricemia through microbial-metabolic crosstalk |
| title_sort | gut kidney axis modulation by viable and inactivated akkermansia muciniphila mitigates avian hyperuricemia through microbial metabolic crosstalk |
| topic | geese poultry |
| url | https://hdl.handle.net/10568/176273 |
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