MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants
The coumarin scopoletin and its glycosylated form scopolin constitute a vast class of natural products that are considered to be high-value compounds, distributed widely in the plant kingdom; they help plants adapt to environmental stresses. However, the underlying molecular mechanism of how scopoli...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2025
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/176115 |
| _version_ | 1855540309870510080 |
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| author | Duan, Z. Wu, F. Yan, Q. Wang, S. Wang, Y. Xie, Z. Li, M. Jones, Christopher S. Zhou, P. Zhang, C. Zhang, J. |
| author_browse | Duan, Z. Jones, Christopher S. Li, M. Wang, S. Wang, Y. Wu, F. Xie, Z. Yan, Q. Zhang, C. Zhang, J. Zhou, P. |
| author_facet | Duan, Z. Wu, F. Yan, Q. Wang, S. Wang, Y. Xie, Z. Li, M. Jones, Christopher S. Zhou, P. Zhang, C. Zhang, J. |
| author_sort | Duan, Z. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The coumarin scopoletin and its glycosylated form scopolin constitute a vast class of natural products that are considered to be high-value compounds, distributed widely in the plant kingdom; they help plants adapt to environmental stresses. However, the underlying molecular mechanism of how scopolin is involved in the regulation of plant drought tolerance remains largely unexplored. Here, UDP-glycosyltransferase 79 (MaUGT79) was genetically mapped as the target gene by bulk segregant analysis sequencing (BSA-seq) from two <i>Melilotus albus</i> near-isogenic lines (NILs). MaUGT79 exhibits glucosyltransferase activity toward scopoletin. The expression of <i>MaUGT79</i> is induced by drought stress, and it was found to mediate scopolin accumulation and reactive oxygen species (ROS) scavenging under drought stress. Moreover, MaMYB4 transcriptionally upregulated <i>MaUGT79</i> was also verified to be involved in modulating scopolin biosynthesis and improving plant drought tolerance. Collectively, this study demonstrates that MaMYB4 enhances drought tolerance through activating <i>MaUGT79</i> expression and promoting scopolin biosynthesis. While <i>MaUGT79</i> represents a key target of MaMYB4-mediated scopolin biosynthesis and drought adaptation, the potential involvement of additional regulatory pathways warrants further investigation. These findings provide important insights into how scopolin accumulation may contribute to plant adaptation to environmental stresses. |
| format | Journal Article |
| id | CGSpace176115 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace1761152025-12-08T10:11:39Z MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants Duan, Z. Wu, F. Yan, Q. Wang, S. Wang, Y. Xie, Z. Li, M. Jones, Christopher S. Zhou, P. Zhang, C. Zhang, J. drought tolerance plants The coumarin scopoletin and its glycosylated form scopolin constitute a vast class of natural products that are considered to be high-value compounds, distributed widely in the plant kingdom; they help plants adapt to environmental stresses. However, the underlying molecular mechanism of how scopolin is involved in the regulation of plant drought tolerance remains largely unexplored. Here, UDP-glycosyltransferase 79 (MaUGT79) was genetically mapped as the target gene by bulk segregant analysis sequencing (BSA-seq) from two <i>Melilotus albus</i> near-isogenic lines (NILs). MaUGT79 exhibits glucosyltransferase activity toward scopoletin. The expression of <i>MaUGT79</i> is induced by drought stress, and it was found to mediate scopolin accumulation and reactive oxygen species (ROS) scavenging under drought stress. Moreover, MaMYB4 transcriptionally upregulated <i>MaUGT79</i> was also verified to be involved in modulating scopolin biosynthesis and improving plant drought tolerance. Collectively, this study demonstrates that MaMYB4 enhances drought tolerance through activating <i>MaUGT79</i> expression and promoting scopolin biosynthesis. While <i>MaUGT79</i> represents a key target of MaMYB4-mediated scopolin biosynthesis and drought adaptation, the potential involvement of additional regulatory pathways warrants further investigation. These findings provide important insights into how scopolin accumulation may contribute to plant adaptation to environmental stresses. 2025-08 2025-08-15T08:41:09Z 2025-08-15T08:41:09Z Journal Article https://hdl.handle.net/10568/176115 en Limited Access Wiley Duan, Z., Wu, F., Yan, Q., Wang, S., Wang, Y., Xie, Z., Li, M., Jones, C.S., Zhou, P., Zhang, C. and Zhang, J. 2025. <i>MaUGT79</i> confers drought tolerance by regulating scopolin biosynthesis in plants. Plant Journal 123(3): e70404. |
| spellingShingle | drought tolerance plants Duan, Z. Wu, F. Yan, Q. Wang, S. Wang, Y. Xie, Z. Li, M. Jones, Christopher S. Zhou, P. Zhang, C. Zhang, J. MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants |
| title | MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants |
| title_full | MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants |
| title_fullStr | MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants |
| title_full_unstemmed | MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants |
| title_short | MaUGT79 confers drought tolerance by regulating scopolin biosynthesis in plants |
| title_sort | maugt79 confers drought tolerance by regulating scopolin biosynthesis in plants |
| topic | drought tolerance plants |
| url | https://hdl.handle.net/10568/176115 |
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