Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam
Background: Wildlife farming is a growing industry, but it poses substantial risks for zoonotic disease transmission, including infections caused by hantaviruses and hepatitis E virus (HEV). This study aimed to determine seroprevalences of these viruses among wildlife farmers and identify associated...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
2025
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/176046 |
| _version_ | 1855541224530771968 |
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| author | Ha Thi Thanh Nguyen Hu Suk Lee Bett, Bernard K. Ling, J. Thang Nguyen-Tien Sinh Dang-Xuan Hung Nguyen-Viet Unger, Fred Lam, Steven Vuong Nghia Bui Tung Duy Dao Lundkvist, Å. Cattell, Genevieve Lindahl, Johanna F. |
| author_browse | Bett, Bernard K. Cattell, Genevieve Ha Thi Thanh Nguyen Hu Suk Lee Hung Nguyen-Viet Lam, Steven Lindahl, Johanna F. Ling, J. Lundkvist, Å. Sinh Dang-Xuan Thang Nguyen-Tien Tung Duy Dao Unger, Fred Vuong Nghia Bui |
| author_facet | Ha Thi Thanh Nguyen Hu Suk Lee Bett, Bernard K. Ling, J. Thang Nguyen-Tien Sinh Dang-Xuan Hung Nguyen-Viet Unger, Fred Lam, Steven Vuong Nghia Bui Tung Duy Dao Lundkvist, Å. Cattell, Genevieve Lindahl, Johanna F. |
| author_sort | Ha Thi Thanh Nguyen |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: Wildlife farming is a growing industry, but it poses substantial risks for zoonotic disease transmission, including infections caused by hantaviruses and hepatitis E virus (HEV). This study aimed to determine seroprevalences of these viruses among wildlife farmers and identify associated risk factors.
Methods: A cross-sectional study was conducted among 210 wildlife farmers in Lao Cai and Dong Nai provinces in Vietnam who raised bats, bamboo rats, civets, and wild boars. Of these, 207 provided serum samples for serological testing for hantavirus and HEV antibodies. Apparent (AP) and true (TP) prevalences were estimated, and multivariable logistic regression was performed to identify risk factors.
Results: The AP of hantavirus IgG was 8.7%, 95% confidence interval (CI): 5.4–13.6 (TP: 4.7%, 95% credible interval (CrI): 0.2–11.1). HEV IgG AP was 26.7%, 95%CI: 20.8–33.2 (TP: 27.1%, 95%CrI: 21.3–33.4). Hantavirus IgM testing was also performed due to higher IgG seroprevalence compared to earlier studies, detecting IgM antibodies in 1.9% of samples (95%CI: 0.6–5.2) (TP: 1.7%, 95%CrI: 0.1–4.7). Hantavirus seropositivity was significantly associated with engaging only in wildlife farming, and not participating in other activities such as hunting, trading, slaughtering, processing, guano collection, or consumption (OR = 2.7, 95% CI: 1.1–6.9). HEV seropositivity was significantly associated with men gender (OR = 3.1, 95%CI: 1.4–7.3), older age (OR = 1.03, 95%CI: 1.0–1.1), raw meat consumption (OR = 6.8, 95%CI: 1.6–31.8), residing at higher altitudes (OR = 31.6, 95%CI: 5.5–204.4), and reporting use of protective clothing (OR = 4.0, 95%CI: 1.4–11.2), although their proper use was not assessed.
Conclusions: This study highlights behavioural and environmental risk factors associated with wildlife farming and zoonotic pathogens exposure. Public health interventions should focus on biosecurity, proper hygiene practices, and risk communication to reduce the transmission in wildlife farming settings. |
| format | Journal Article |
| id | CGSpace176046 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | CGSpace1760462025-12-08T09:54:28Z Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam Ha Thi Thanh Nguyen Hu Suk Lee Bett, Bernard K. Ling, J. Thang Nguyen-Tien Sinh Dang-Xuan Hung Nguyen-Viet Unger, Fred Lam, Steven Vuong Nghia Bui Tung Duy Dao Lundkvist, Å. Cattell, Genevieve Lindahl, Johanna F. hantavirus health hepatitis wildlife zoonoses Background: Wildlife farming is a growing industry, but it poses substantial risks for zoonotic disease transmission, including infections caused by hantaviruses and hepatitis E virus (HEV). This study aimed to determine seroprevalences of these viruses among wildlife farmers and identify associated risk factors. Methods: A cross-sectional study was conducted among 210 wildlife farmers in Lao Cai and Dong Nai provinces in Vietnam who raised bats, bamboo rats, civets, and wild boars. Of these, 207 provided serum samples for serological testing for hantavirus and HEV antibodies. Apparent (AP) and true (TP) prevalences were estimated, and multivariable logistic regression was performed to identify risk factors. Results: The AP of hantavirus IgG was 8.7%, 95% confidence interval (CI): 5.4–13.6 (TP: 4.7%, 95% credible interval (CrI): 0.2–11.1). HEV IgG AP was 26.7%, 95%CI: 20.8–33.2 (TP: 27.1%, 95%CrI: 21.3–33.4). Hantavirus IgM testing was also performed due to higher IgG seroprevalence compared to earlier studies, detecting IgM antibodies in 1.9% of samples (95%CI: 0.6–5.2) (TP: 1.7%, 95%CrI: 0.1–4.7). Hantavirus seropositivity was significantly associated with engaging only in wildlife farming, and not participating in other activities such as hunting, trading, slaughtering, processing, guano collection, or consumption (OR = 2.7, 95% CI: 1.1–6.9). HEV seropositivity was significantly associated with men gender (OR = 3.1, 95%CI: 1.4–7.3), older age (OR = 1.03, 95%CI: 1.0–1.1), raw meat consumption (OR = 6.8, 95%CI: 1.6–31.8), residing at higher altitudes (OR = 31.6, 95%CI: 5.5–204.4), and reporting use of protective clothing (OR = 4.0, 95%CI: 1.4–11.2), although their proper use was not assessed. Conclusions: This study highlights behavioural and environmental risk factors associated with wildlife farming and zoonotic pathogens exposure. Public health interventions should focus on biosecurity, proper hygiene practices, and risk communication to reduce the transmission in wildlife farming settings. 2025-08-07 2025-08-08T09:02:25Z 2025-08-08T09:02:25Z Journal Article https://hdl.handle.net/10568/176046 en Open Access Ha Thi Thanh Nguyen, Hu Suk Lee, Bett, B., Ling, J., Thang Nguyen-Tien, Sinh Dang-Xuan, Hung Nguyen-Viet, Unger, F., Lam, S., Vuong Nghia Bui, Tung Duy Dao, Lundkvist, Å., Cattell, G. and Lindahl, J.F. 2025. Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam. PLOS ONE 20(8): e0329570. |
| spellingShingle | hantavirus health hepatitis wildlife zoonoses Ha Thi Thanh Nguyen Hu Suk Lee Bett, Bernard K. Ling, J. Thang Nguyen-Tien Sinh Dang-Xuan Hung Nguyen-Viet Unger, Fred Lam, Steven Vuong Nghia Bui Tung Duy Dao Lundkvist, Å. Cattell, Genevieve Lindahl, Johanna F. Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam |
| title | Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam |
| title_full | Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam |
| title_fullStr | Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam |
| title_full_unstemmed | Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam |
| title_short | Seroprevalence and risk factors of hantavirus and hepatitis E virus exposure among wildlife farmers in Vietnam |
| title_sort | seroprevalence and risk factors of hantavirus and hepatitis e virus exposure among wildlife farmers in vietnam |
| topic | hantavirus health hepatitis wildlife zoonoses |
| url | https://hdl.handle.net/10568/176046 |
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