Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project
Background It is unclear whether 25(OH)D concentrations in children and female adults may be influenced by inflammation and thus require adjustment when estimating the population prevalence of vitamin D deficiency. Objectives We examined correlations between inflammation biomarkers, CRP or alpha-1-...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/175657 |
| _version_ | 1855519802394673152 |
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| author | Young, Melissa F. Ou, Jiangda Duong, Cam Luo, Hanqi Beyh, Yara S. Meng, Jiawei Gernand, Alison D. Roth, Daniel E. Suchdev, Parminder S. |
| author_browse | Beyh, Yara S. Duong, Cam Gernand, Alison D. Luo, Hanqi Meng, Jiawei Ou, Jiangda Roth, Daniel E. Suchdev, Parminder S. Young, Melissa F. |
| author_facet | Young, Melissa F. Ou, Jiangda Duong, Cam Luo, Hanqi Beyh, Yara S. Meng, Jiawei Gernand, Alison D. Roth, Daniel E. Suchdev, Parminder S. |
| author_sort | Young, Melissa F. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background
It is unclear whether 25(OH)D concentrations in children and female adults may be influenced by inflammation and thus require adjustment when estimating the population prevalence of vitamin D deficiency.
Objectives
We examined correlations between inflammation biomarkers, CRP or alpha-1-acid glycoprotein (AGP), and serum 25(OH)D concentrations among preschool children (PSC; 6–59 mo) and nonpregnant females of reproductive age (FRA; 15–49 y).
Methods
We analyzed cross-sectional data from 6 nationally representative nutrition surveys (Afghanistan, Cambodia, Pakistan, UK, USA, and Vietnam) conducted among PSC (n = 9880) and FRA (n = 14,749) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia project. Rank correlations between CRP or AGP and 25(OH)D concentrations were examined while taking into account complex survey design effects.
Results
Among both PSC and FRA, correlations between inflammation and vitamin D biomarkers were weak and inconsistent across surveys. For PSC, correlation coefficients between CRP and 25(OH)D concentrations ranged from −0.04 to 0.08, and correlations between AGP and 25(OH)D ranged from 0.01 to 0.05. Correlation coefficients between CRP and 25(OH)D for FRA ranged from −0.11 to 0.14, and correlations between AGP and 25(OH)D concentrations ranged from −0.05 to 0.01.
Conclusions
Based on the weak and inconsistent correlations between CRP or AGP and 25(OH)D, there is no rationale to adjust for these inflammation biomarkers when estimating population prevalence of vitamin D deficiency in PSC or FRA. |
| format | Journal Article |
| id | CGSpace175657 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1756572025-12-08T09:54:28Z Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project Young, Melissa F. Ou, Jiangda Duong, Cam Luo, Hanqi Beyh, Yara S. Meng, Jiawei Gernand, Alison D. Roth, Daniel E. Suchdev, Parminder S. vitamin D inflammation biomarkers anaemia women children Background It is unclear whether 25(OH)D concentrations in children and female adults may be influenced by inflammation and thus require adjustment when estimating the population prevalence of vitamin D deficiency. Objectives We examined correlations between inflammation biomarkers, CRP or alpha-1-acid glycoprotein (AGP), and serum 25(OH)D concentrations among preschool children (PSC; 6–59 mo) and nonpregnant females of reproductive age (FRA; 15–49 y). Methods We analyzed cross-sectional data from 6 nationally representative nutrition surveys (Afghanistan, Cambodia, Pakistan, UK, USA, and Vietnam) conducted among PSC (n = 9880) and FRA (n = 14,749) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia project. Rank correlations between CRP or AGP and 25(OH)D concentrations were examined while taking into account complex survey design effects. Results Among both PSC and FRA, correlations between inflammation and vitamin D biomarkers were weak and inconsistent across surveys. For PSC, correlation coefficients between CRP and 25(OH)D concentrations ranged from −0.04 to 0.08, and correlations between AGP and 25(OH)D ranged from 0.01 to 0.05. Correlation coefficients between CRP and 25(OH)D for FRA ranged from −0.11 to 0.14, and correlations between AGP and 25(OH)D concentrations ranged from −0.05 to 0.01. Conclusions Based on the weak and inconsistent correlations between CRP or AGP and 25(OH)D, there is no rationale to adjust for these inflammation biomarkers when estimating population prevalence of vitamin D deficiency in PSC or FRA. 2023-01 2025-07-16T20:48:10Z 2025-07-16T20:48:10Z Journal Article https://hdl.handle.net/10568/175657 en Open Access Elsevier Young, Melissa F.; Ou, Jiangda; Duong, Cam; Luo, Hanqi; Beyh, Yara S.; Meng, Jiawei; et al. 2023. Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project. American Journal of Clinical Nutrition 117(1): 175-181. https://doi.org/10.1016/j.ajcnut.2022.10.018 |
| spellingShingle | vitamin D inflammation biomarkers anaemia women children Young, Melissa F. Ou, Jiangda Duong, Cam Luo, Hanqi Beyh, Yara S. Meng, Jiawei Gernand, Alison D. Roth, Daniel E. Suchdev, Parminder S. Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project |
| title | Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project |
| title_full | Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project |
| title_fullStr | Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project |
| title_full_unstemmed | Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project |
| title_short | Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project |
| title_sort | assessment of vitamin d status and association with inflammation biomarkers reflecting inflammation and nutritional determinants of anemia brinda project |
| topic | vitamin D inflammation biomarkers anaemia women children |
| url | https://hdl.handle.net/10568/175657 |
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