Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol
Background Zinc deficiency poses significant health risks, particularly in low-income settings. This study aims to evaluate the impact of agronomically zinc biofortified (fermented and non-fermented) and post-harvest wheat flour flatbread on zinc status and metabolic health in adolescents and adult...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
2024
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| Acceso en línea: | https://hdl.handle.net/10568/175567 |
| _version_ | 1855519325875601408 |
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| author | Das, Jai K. Padhani, Zahra Ali Khan, Muhammad Mirani, Mushtaq Rizvi, Arjumand Chauhadry, Imran Ahmed Yasin, Rahima Ismail, Tariq Akhtar, Saeed Begum, Kehkashan Iqbal, Junaid Humayun, Khadija Naseem, Hamna Amir Malik, Kauser Abdulla Bhutta, Zulfiqar A. |
| author_browse | Akhtar, Saeed Begum, Kehkashan Bhutta, Zulfiqar A. Chauhadry, Imran Ahmed Das, Jai K. Humayun, Khadija Iqbal, Junaid Ismail, Tariq Khan, Muhammad Malik, Kauser Abdulla Mirani, Mushtaq Naseem, Hamna Amir Padhani, Zahra Ali Rizvi, Arjumand Yasin, Rahima |
| author_facet | Das, Jai K. Padhani, Zahra Ali Khan, Muhammad Mirani, Mushtaq Rizvi, Arjumand Chauhadry, Imran Ahmed Yasin, Rahima Ismail, Tariq Akhtar, Saeed Begum, Kehkashan Iqbal, Junaid Humayun, Khadija Naseem, Hamna Amir Malik, Kauser Abdulla Bhutta, Zulfiqar A. |
| author_sort | Das, Jai K. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background
Zinc deficiency poses significant health risks, particularly in low-income settings. This study aims to evaluate the impact of agronomically zinc biofortified (fermented and non-fermented) and post-harvest wheat flour flatbread on zinc status and metabolic health in adolescents and adult women in rural Pakistan.
Methods
A four-arm triple-blind randomized controlled trial will be conducted in a rural district of Paki stan. Participants (adolescents aged 10–19 and adult women aged 20–40) will be assigned
to receive fermented or unfermented high zinc agronomically biofortified wheat flour flat bread, post-harvest zinc-fortified wheat flour flatbread, or low zinc conventional whole wheat
flour flatbread. The meal would be served once a day, six days a week for six months. The study aims to enroll 1000 participants and will be analyzed based on the intention-to-treat
principle. The trial is registered with number NCT06092515.
Outcomes
Primary outcomes will include serum zinc concentration and metabolic markers, while secondary outcomes include anthropometric measurements, blood pressure, and dietary intake.
Conclusion
This trial will provide valuable insights into the efficacy of agronomically zinc biofortified wheat flour in improving zinc status and metabolic health. Findings may inform public health
strategies to combat zinc deficiency in resource-limited settings. |
| format | Journal Article |
| id | CGSpace175567 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| record_format | dspace |
| spelling | CGSpace1755672025-10-26T12:55:21Z Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol Das, Jai K. Padhani, Zahra Ali Khan, Muhammad Mirani, Mushtaq Rizvi, Arjumand Chauhadry, Imran Ahmed Yasin, Rahima Ismail, Tariq Akhtar, Saeed Begum, Kehkashan Iqbal, Junaid Humayun, Khadija Naseem, Hamna Amir Malik, Kauser Abdulla Bhutta, Zulfiqar A. zinc nutrient deficiencies biofortification wheat flour Background Zinc deficiency poses significant health risks, particularly in low-income settings. This study aims to evaluate the impact of agronomically zinc biofortified (fermented and non-fermented) and post-harvest wheat flour flatbread on zinc status and metabolic health in adolescents and adult women in rural Pakistan. Methods A four-arm triple-blind randomized controlled trial will be conducted in a rural district of Paki stan. Participants (adolescents aged 10–19 and adult women aged 20–40) will be assigned to receive fermented or unfermented high zinc agronomically biofortified wheat flour flat bread, post-harvest zinc-fortified wheat flour flatbread, or low zinc conventional whole wheat flour flatbread. The meal would be served once a day, six days a week for six months. The study aims to enroll 1000 participants and will be analyzed based on the intention-to-treat principle. The trial is registered with number NCT06092515. Outcomes Primary outcomes will include serum zinc concentration and metabolic markers, while secondary outcomes include anthropometric measurements, blood pressure, and dietary intake. Conclusion This trial will provide valuable insights into the efficacy of agronomically zinc biofortified wheat flour in improving zinc status and metabolic health. Findings may inform public health strategies to combat zinc deficiency in resource-limited settings. 2024-06 2025-07-09T17:40:00Z 2025-07-09T17:40:00Z Journal Article https://hdl.handle.net/10568/175567 en Open Access Das, Jai K.; Padhani, Zahra Ali; Khan, Muhammad; Mirani, Mushtaq; Rizvi, Arjumand; Chauhadry, Imran Ahmed; et al. 2024. Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol. PLoS ONE 19(6): e0304462. https://doi.org/10.1371/journal.pone.0304462 |
| spellingShingle | zinc nutrient deficiencies biofortification wheat flour Das, Jai K. Padhani, Zahra Ali Khan, Muhammad Mirani, Mushtaq Rizvi, Arjumand Chauhadry, Imran Ahmed Yasin, Rahima Ismail, Tariq Akhtar, Saeed Begum, Kehkashan Iqbal, Junaid Humayun, Khadija Naseem, Hamna Amir Malik, Kauser Abdulla Bhutta, Zulfiqar A. Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol |
| title | Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol |
| title_full | Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol |
| title_fullStr | Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol |
| title_full_unstemmed | Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol |
| title_short | Efficacy of Zinc Fortified and Fermented Wheat Flour (EZAFFAW): A randomized controlled trial protocol |
| title_sort | efficacy of zinc fortified and fermented wheat flour ezaffaw a randomized controlled trial protocol |
| topic | zinc nutrient deficiencies biofortification wheat flour |
| url | https://hdl.handle.net/10568/175567 |
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