Anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project
Objectives: To investigate association between anemia status along with the changes during pregnancy and birth outcomes (including preterm birth, small-for-gestational age [SGA], and low birth weight [LBW]). Methods: Data from the Biomarkers Reflecting Inflammation and Nutritional Determinants of An...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Abstract |
| Language: | Inglés |
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2025
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/175253 |
| _version_ | 1855527733615919104 |
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| author | Liu, Lei Luo, Hanqi Werner, Rochelle E. Jefferds, Maria Elena D. Addo, Yaw Suchdev, Parminder S. Usha, Ramakrishnan Nguyen, Phuong Hong Dewey, Kathryn G. Ramírez-Luzuriaga, Maria J. Young, Melissa F. Ko, Yi-An |
| author_browse | Addo, Yaw Dewey, Kathryn G. Jefferds, Maria Elena D. Ko, Yi-An Liu, Lei Luo, Hanqi Nguyen, Phuong Hong Ramírez-Luzuriaga, Maria J. Suchdev, Parminder S. Usha, Ramakrishnan Werner, Rochelle E. Young, Melissa F. |
| author_facet | Liu, Lei Luo, Hanqi Werner, Rochelle E. Jefferds, Maria Elena D. Addo, Yaw Suchdev, Parminder S. Usha, Ramakrishnan Nguyen, Phuong Hong Dewey, Kathryn G. Ramírez-Luzuriaga, Maria J. Young, Melissa F. Ko, Yi-An |
| author_sort | Liu, Lei |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Objectives: To investigate association between anemia status along with the changes during pregnancy and birth outcomes (including preterm birth, small-for-gestational age [SGA], and low birth weight [LBW]).
Methods: Data from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project included 7 datasets (RCT) across 6 countries (n=7,176). Pregnant women were categorized as having IDA (anemia per WHO cutoffs and iron deficiency [inflammation-adjusted serum ferritin < 15 μg/L or soluble transferrin receptor >8.3 mg/L]), non-IDA, or no anemia based on the first study visit. In addition, for women with two or more visits (n=6163), biomarkers from the first and last visits were used to define any change in anemia status (e.g., from IDA to non-IDA), resulting in 9 combinations of anemia status change. Associations between first-visit anemia status and the changes during pregnancy with adverse birth outcomes were assessed using modified Poisson regression to obtain relative risk estimate (RR). Models adjusted for age, inflammation, dataset, socioeconomic status, study intervention, and malaria.
Results: At the first visit (median 13 weeks gestation), 6.4% had IDA and 15.2% had non-IDA. IDA vs. no anemia was associated with a higher risk of preterm birth (RR=1.55, p< 0.01), while non-IDA was not associated with any adverse birth outcomes. Compared with women without anemia throughout pregnancy, having no-anemia (first visit) to IDA (last visit) was associated with a reduced risk of SGA (RR=0.86, p=0.03) and LBW (0.73, p< 0.01), but having no anemia to non-IDA was associated with an increased risk of SGA (1.12, p=0.04) and LBW (1.27, p< 0.01). Having non-IDA to no anemia had a lower risk of SGA (0.77, p=0.04) vs. those stayed with non-IDA.
Conclusions: IDA early in pregnancy is associated with an increased risk of preterm birth. Changes in anemia status across pregnancy show mixed effects on birth outcomes and better understanding the underlying mechanisms may be useful to reduce adverse outcomes. |
| format | Abstract |
| id | CGSpace175253 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| record_format | dspace |
| spelling | CGSpace1752532025-12-08T09:54:28Z Anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project Liu, Lei Luo, Hanqi Werner, Rochelle E. Jefferds, Maria Elena D. Addo, Yaw Suchdev, Parminder S. Usha, Ramakrishnan Nguyen, Phuong Hong Dewey, Kathryn G. Ramírez-Luzuriaga, Maria J. Young, Melissa F. Ko, Yi-An anaemia iron pregnancy prematurity Objectives: To investigate association between anemia status along with the changes during pregnancy and birth outcomes (including preterm birth, small-for-gestational age [SGA], and low birth weight [LBW]). Methods: Data from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project included 7 datasets (RCT) across 6 countries (n=7,176). Pregnant women were categorized as having IDA (anemia per WHO cutoffs and iron deficiency [inflammation-adjusted serum ferritin < 15 μg/L or soluble transferrin receptor >8.3 mg/L]), non-IDA, or no anemia based on the first study visit. In addition, for women with two or more visits (n=6163), biomarkers from the first and last visits were used to define any change in anemia status (e.g., from IDA to non-IDA), resulting in 9 combinations of anemia status change. Associations between first-visit anemia status and the changes during pregnancy with adverse birth outcomes were assessed using modified Poisson regression to obtain relative risk estimate (RR). Models adjusted for age, inflammation, dataset, socioeconomic status, study intervention, and malaria. Results: At the first visit (median 13 weeks gestation), 6.4% had IDA and 15.2% had non-IDA. IDA vs. no anemia was associated with a higher risk of preterm birth (RR=1.55, p< 0.01), while non-IDA was not associated with any adverse birth outcomes. Compared with women without anemia throughout pregnancy, having no-anemia (first visit) to IDA (last visit) was associated with a reduced risk of SGA (RR=0.86, p=0.03) and LBW (0.73, p< 0.01), but having no anemia to non-IDA was associated with an increased risk of SGA (1.12, p=0.04) and LBW (1.27, p< 0.01). Having non-IDA to no anemia had a lower risk of SGA (0.77, p=0.04) vs. those stayed with non-IDA. Conclusions: IDA early in pregnancy is associated with an increased risk of preterm birth. Changes in anemia status across pregnancy show mixed effects on birth outcomes and better understanding the underlying mechanisms may be useful to reduce adverse outcomes. 2025-05 2025-06-23T14:58:19Z 2025-06-23T14:58:19Z Abstract https://hdl.handle.net/10568/175253 en Open Access Liu, Lei; Luo, Hanqi; Werner, Rochelle E.; Jefferds, Maria Elena D.; Addo, Yaw; Suchdev, Parminder S.; et al. 2025. Anemia with and without iro deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project. Current Developments in Nutrition 9(Supplement 2): 107048. https://doi.org/10.1016/j.cdnut.2025.107048 |
| spellingShingle | anaemia iron pregnancy prematurity Liu, Lei Luo, Hanqi Werner, Rochelle E. Jefferds, Maria Elena D. Addo, Yaw Suchdev, Parminder S. Usha, Ramakrishnan Nguyen, Phuong Hong Dewey, Kathryn G. Ramírez-Luzuriaga, Maria J. Young, Melissa F. Ko, Yi-An Anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project |
| title | Anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project |
| title_full | Anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project |
| title_fullStr | Anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project |
| title_full_unstemmed | Anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project |
| title_short | Anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes: BRINDA Project |
| title_sort | anemia with and without iron deficiency during pregnancy and association with adverse birth outcomes brinda project |
| topic | anaemia iron pregnancy prematurity |
| url | https://hdl.handle.net/10568/175253 |
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