Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials
Objective To evaluate the effect of iron supplementation on mental and motor development in children through a systematic review of randomised controlled trials (RCTs). Data sources Electronic databases, personal files, hand search of reviews, bibliographies of books, abstracts and proceedings of i...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Cambridge University Press
2005
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/174644 |
| _version_ | 1855526289620860928 |
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| author | Sachdev, H. P. S. Gera, Tarun Nestel, Penelope |
| author_browse | Gera, Tarun Nestel, Penelope Sachdev, H. P. S. |
| author_facet | Sachdev, H. P. S. Gera, Tarun Nestel, Penelope |
| author_sort | Sachdev, H. P. S. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Objective
To evaluate the effect of iron supplementation on mental and motor development in children through a systematic review of randomised controlled trials (RCTs).
Data sources
Electronic databases, personal files, hand search of reviews, bibliographies of books, abstracts and proceedings of international conferences.
Review methods
RCTs with interventions that included oral or parenteral iron supplementation, fortified formula milk or cereals were evaluated. The outcomes studied were mental and motor development scores and various individual development tests employed, including Bayley mental and psychomotor development indices and intelligence quotient.
Results
The pooled estimate (random effects model) of mental development score standardised mean difference (SMD) was 0.30 (95% confidence interval (CI) 0.15 to 0.46,P< 0.001;P< 0.001 for heterogeneity). Initial anaemia and iron-deficiency anaemia were significant explanatory variables for heterogeneity. The pooled estimate of Bayley Mental Development Index (weighted mean difference) in younger children (<27 months old) was 0.95 (95% CI −0.56 to 2.46,P= 0.22;P= 0.016 for heterogeneity). For intelligence quotient scores (≥8 years age), the pooled SMD was 0.41 (95% CI 0.20 to 0.62,P< 0.001;P= 0.07 for heterogeneity). There was no effect of iron supplementation on motor development score (SMD 0.09, 95% CI -0.08 to 0.26,P= 0.28;P= 0.028 for heterogeneity).
Conclusions
Iron supplementation improves mental development score modestly. This effect is particularly apparent for intelligence tests above 7 years of age and in initially anaemic or iron-deficient anaemic subjects. There is no convincing evidence that iron treatment has an effect on mental development in children below 27 months of age or on motor development. |
| format | Journal Article |
| id | CGSpace174644 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace1746442025-05-16T18:17:39Z Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials Sachdev, H. P. S. Gera, Tarun Nestel, Penelope iron mineral supplements child development mental ability Objective To evaluate the effect of iron supplementation on mental and motor development in children through a systematic review of randomised controlled trials (RCTs). Data sources Electronic databases, personal files, hand search of reviews, bibliographies of books, abstracts and proceedings of international conferences. Review methods RCTs with interventions that included oral or parenteral iron supplementation, fortified formula milk or cereals were evaluated. The outcomes studied were mental and motor development scores and various individual development tests employed, including Bayley mental and psychomotor development indices and intelligence quotient. Results The pooled estimate (random effects model) of mental development score standardised mean difference (SMD) was 0.30 (95% confidence interval (CI) 0.15 to 0.46,P< 0.001;P< 0.001 for heterogeneity). Initial anaemia and iron-deficiency anaemia were significant explanatory variables for heterogeneity. The pooled estimate of Bayley Mental Development Index (weighted mean difference) in younger children (<27 months old) was 0.95 (95% CI −0.56 to 2.46,P= 0.22;P= 0.016 for heterogeneity). For intelligence quotient scores (≥8 years age), the pooled SMD was 0.41 (95% CI 0.20 to 0.62,P< 0.001;P= 0.07 for heterogeneity). There was no effect of iron supplementation on motor development score (SMD 0.09, 95% CI -0.08 to 0.26,P= 0.28;P= 0.028 for heterogeneity). Conclusions Iron supplementation improves mental development score modestly. This effect is particularly apparent for intelligence tests above 7 years of age and in initially anaemic or iron-deficient anaemic subjects. There is no convincing evidence that iron treatment has an effect on mental development in children below 27 months of age or on motor development. 2005-04 2025-05-16T18:17:38Z 2025-05-16T18:17:38Z Journal Article https://hdl.handle.net/10568/174644 en http://indianpediatrics.net/jan2007/jan-15-24.htm Limited Access Cambridge University Press Sachdev, H. P. S.; Gera, Tarun; and Nestel, Penelope. 2005. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutrition 8(2): 117-132. https://doi.org/10.1079/PHN2004677 |
| spellingShingle | iron mineral supplements child development mental ability Sachdev, H. P. S. Gera, Tarun Nestel, Penelope Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials |
| title | Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials |
| title_full | Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials |
| title_fullStr | Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials |
| title_full_unstemmed | Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials |
| title_short | Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials |
| title_sort | effect of iron supplementation on mental and motor development in children systematic review of randomised controlled trials |
| topic | iron mineral supplements child development mental ability |
| url | https://hdl.handle.net/10568/174644 |
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