Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX
African swine fever virus originated in a wildlife cycle in East Africa and spread to domestic pigs. At least twenty-three genotypes are present in Africa whereas only genotypes I and II have spread to other continents. Vaccine development has been directed mainly to genotype II. The ability of geno...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Informa UK Limited
2025
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/174531 |
| _version_ | 1855536752600547328 |
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| author | Rathakrishnan, A. Hemmink, Johanneke D. Petrovan, V. Reis, A.L. Dixon, L.K. |
| author_browse | Dixon, L.K. Hemmink, Johanneke D. Petrovan, V. Rathakrishnan, A. Reis, A.L. |
| author_facet | Rathakrishnan, A. Hemmink, Johanneke D. Petrovan, V. Reis, A.L. Dixon, L.K. |
| author_sort | Rathakrishnan, A. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | African swine fever virus originated in a wildlife cycle in East Africa and spread to domestic pigs. At least twenty-three genotypes are present in Africa whereas only genotypes I and II have spread to other continents. Vaccine development has been directed mainly to genotype II. The ability of genotype II vaccines to induce cross-protection against other genotypes is unknown. Here, we compared cross-protection induced in pigs by an attenuated multiple gene-deleted genotype II modified live vaccine candidate against challenge with different genotypes. Protection against homologous virulent genotype II virus was 100%. Cross-protection against virulent genotype I virus varied between 57 and 71%. However, no protection was achieved against genotype IX challenge. The results indicate potential for use of vaccines in regions where genotypes I and II are circulating. |
| format | Journal Article |
| id | CGSpace174531 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Informa UK Limited |
| publisherStr | Informa UK Limited |
| record_format | dspace |
| spelling | CGSpace1745312025-10-26T12:55:49Z Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX Rathakrishnan, A. Hemmink, Johanneke D. Petrovan, V. Reis, A.L. Dixon, L.K. african swine fever swine vaccines African swine fever virus originated in a wildlife cycle in East Africa and spread to domestic pigs. At least twenty-three genotypes are present in Africa whereas only genotypes I and II have spread to other continents. Vaccine development has been directed mainly to genotype II. The ability of genotype II vaccines to induce cross-protection against other genotypes is unknown. Here, we compared cross-protection induced in pigs by an attenuated multiple gene-deleted genotype II modified live vaccine candidate against challenge with different genotypes. Protection against homologous virulent genotype II virus was 100%. Cross-protection against virulent genotype I virus varied between 57 and 71%. However, no protection was achieved against genotype IX challenge. The results indicate potential for use of vaccines in regions where genotypes I and II are circulating. 2025-12-31 2025-05-13T06:01:23Z 2025-05-13T06:01:23Z Journal Article https://hdl.handle.net/10568/174531 en Open Access Informa UK Limited Rathakrishnan, A., Hemmink, J.D., Petrovan, V., Reis, A.L. and Dixon, L.K. 2025. Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX. Emerging Microbes and Infections 14(1): 2505645. |
| spellingShingle | african swine fever swine vaccines Rathakrishnan, A. Hemmink, Johanneke D. Petrovan, V. Reis, A.L. Dixon, L.K. Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX |
| title | Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX |
| title_full | Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX |
| title_fullStr | Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX |
| title_full_unstemmed | Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX |
| title_short | Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX |
| title_sort | gene modified genotype ii live attenuated african swine fever virus induces cross protection against genotype i but not against genotype ix |
| topic | african swine fever swine vaccines |
| url | https://hdl.handle.net/10568/174531 |
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