Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays
Trifoliate yam (Dioscorea dumetorum) is traditionally used to treat diabetics in Nigeria. However, almost no information is available on its antidiabetic constituents and their natural variance. Hence, the activity of methanolic tuber extracts of 67 trifoliate yam accessions from the largest collect...
| Autores principales: | , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2025
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/174510 |
| _version_ | 1855538935739973632 |
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| author | Aiyedun, P.O. Sonibare, M.A. Gueye, B. Albach, D.C. Heil, J. Morlock, G.E. |
| author_browse | Aiyedun, P.O. Albach, D.C. Gueye, B. Heil, J. Morlock, G.E. Sonibare, M.A. |
| author_facet | Aiyedun, P.O. Sonibare, M.A. Gueye, B. Albach, D.C. Heil, J. Morlock, G.E. |
| author_sort | Aiyedun, P.O. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Trifoliate yam (Dioscorea dumetorum) is traditionally used to treat diabetics in Nigeria. However, almost no information is available on its antidiabetic constituents and their natural variance. Hence, the activity of methanolic tuber extracts of 67 trifoliate yam accessions from the largest collection in Africa was proven by four colorimetric antidiabetic and antioxidant in vitro assays, as diabetes is also linked with oxidative stress. For the first time, selected accessions were also analyzed by planar bioactivity profiling. It has a comparatively higher, more differentiated information content, is more sustainable in terms of material consumption, and enables straightforward compound prioritization and characterization. Up to a dozen individual antioxidant zones were revealed as well as one prominent zone inhibiting α-glucosidase and α-amylase. The latter inhibition zone was tentatively assigned to palmitic, linoleic, oleic, linolenic, oxo-nonanoic fatty acids by direct elution to heated electrospray ionization high-resolution mass spectrometry. |
| format | Journal Article |
| id | CGSpace174510 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1745102025-12-08T10:11:39Z Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays Aiyedun, P.O. Sonibare, M.A. Gueye, B. Albach, D.C. Heil, J. Morlock, G.E. dioscorea bioactive properties chromatography Trifoliate yam (Dioscorea dumetorum) is traditionally used to treat diabetics in Nigeria. However, almost no information is available on its antidiabetic constituents and their natural variance. Hence, the activity of methanolic tuber extracts of 67 trifoliate yam accessions from the largest collection in Africa was proven by four colorimetric antidiabetic and antioxidant in vitro assays, as diabetes is also linked with oxidative stress. For the first time, selected accessions were also analyzed by planar bioactivity profiling. It has a comparatively higher, more differentiated information content, is more sustainable in terms of material consumption, and enables straightforward compound prioritization and characterization. Up to a dozen individual antioxidant zones were revealed as well as one prominent zone inhibiting α-glucosidase and α-amylase. The latter inhibition zone was tentatively assigned to palmitic, linoleic, oleic, linolenic, oxo-nonanoic fatty acids by direct elution to heated electrospray ionization high-resolution mass spectrometry. 2025-01 2025-05-09T09:55:04Z 2025-05-09T09:55:04Z Journal Article https://hdl.handle.net/10568/174510 en Open Access application/pdf Elsevier Aiyedun, P.O., Sonibare, M.A., Gueye, B., Albach, D.C., Heil, J. & Morlock, G.E. (2025). Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays. Fitoterapia, 180: 106299, 1-12. |
| spellingShingle | dioscorea bioactive properties chromatography Aiyedun, P.O. Sonibare, M.A. Gueye, B. Albach, D.C. Heil, J. Morlock, G.E. Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays |
| title | Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays |
| title_full | Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays |
| title_fullStr | Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays |
| title_full_unstemmed | Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays |
| title_short | Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays |
| title_sort | antidiabetic and antioxidant profiling of 67 african trifoliate yam accessions by planar on surface assays versus in vitro assays |
| topic | dioscorea bioactive properties chromatography |
| url | https://hdl.handle.net/10568/174510 |
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