Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial
Balanced energy-protein (BEP) supplementation during pregnancy and lactation can improve birth outcomes and infant growth, with the gut microbiome as a potential mediator. The MISAME-III randomized controlled trial (ClinicalTrial.gov: NCT03533712) assessed the effect of BEP supplementation, provided...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2025
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/173729 |
| _version_ | 1855534202637778944 |
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| author | Deng, Lishi Taelman, Steff Olm, Matthew R. Toe, Laeticia Celine Balini, Eva Ouédraogo, Lionel Olivier Bastos-Moreira, Yuri Argaw, Alemayehu Tesfamariam, Kokeb Sonnenburg, Erica D. Hanley-Cook, Giles T. Ouédraogo, Moctar Ganaba, Rasmané Criekinge, Wim Van Huybregts, Lieven Stock, Michiel Kolsteren, Patrick Sonnenburg, Justin L. Lachat, Carl Dailey-Chwalibóg, Trenton |
| author_browse | Argaw, Alemayehu Balini, Eva Bastos-Moreira, Yuri Criekinge, Wim Van Dailey-Chwalibóg, Trenton Deng, Lishi Ganaba, Rasmané Hanley-Cook, Giles T. Huybregts, Lieven Kolsteren, Patrick Lachat, Carl Olm, Matthew R. Ouédraogo, Lionel Olivier Ouédraogo, Moctar Sonnenburg, Erica D. Sonnenburg, Justin L. Stock, Michiel Taelman, Steff Tesfamariam, Kokeb Toe, Laeticia Celine |
| author_facet | Deng, Lishi Taelman, Steff Olm, Matthew R. Toe, Laeticia Celine Balini, Eva Ouédraogo, Lionel Olivier Bastos-Moreira, Yuri Argaw, Alemayehu Tesfamariam, Kokeb Sonnenburg, Erica D. Hanley-Cook, Giles T. Ouédraogo, Moctar Ganaba, Rasmané Criekinge, Wim Van Huybregts, Lieven Stock, Michiel Kolsteren, Patrick Sonnenburg, Justin L. Lachat, Carl Dailey-Chwalibóg, Trenton |
| author_sort | Deng, Lishi |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Balanced energy-protein (BEP) supplementation during pregnancy and lactation can improve birth outcomes and infant growth, with the gut microbiome as a potential mediator. The MISAME-III randomized controlled trial (ClinicalTrial.gov: NCT03533712) assessed the effect of BEP supplementation, provided during pregnancy and the first six months of lactation, on small-for-gestational age prevalence and length-for-age Z-scores at six months in rural Burkina Faso. Nested within MISAME-III, this sub-study examines the impact of BEP supplementation on maternal and infant gut microbiomes and their mediating role in birth outcomes and infant growth. A total of 152 mother-infant dyads (n = 71 intervention, n = 81 control) were included for metagenomic sequencing, with stool samples collected at the second and third trimesters, and at 1–2 and 5–6 months postpartum. BEP supplementation significantly altered maternal gut microbiome diversity, composition, and function, particularly those with immune-modulatory properties. Pathways linked to lipopolysaccharide biosynthesis were depleted and the species Bacteroides fragilis was enriched in BEP-supplemented mothers. Maternal BEP supplementation also accelerated infant microbiome changes and enhanced carbohydrate metabolism. Causal mediation analyses identified specific taxa mediating the effect of BEP on birth outcomes and infant growth. These findings suggest that maternal supplementation modulates gut microbiome composition and influences early-life development in resource-limited settings. |
| format | Journal Article |
| id | CGSpace173729 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2025 |
| publishDateRange | 2025 |
| publishDateSort | 2025 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1737292025-10-26T12:55:15Z Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial Deng, Lishi Taelman, Steff Olm, Matthew R. Toe, Laeticia Celine Balini, Eva Ouédraogo, Lionel Olivier Bastos-Moreira, Yuri Argaw, Alemayehu Tesfamariam, Kokeb Sonnenburg, Erica D. Hanley-Cook, Giles T. Ouédraogo, Moctar Ganaba, Rasmané Criekinge, Wim Van Huybregts, Lieven Stock, Michiel Kolsteren, Patrick Sonnenburg, Justin L. Lachat, Carl Dailey-Chwalibóg, Trenton carbohydrate metabolism infants maternal and child health maternal behaviour microbiomes pregnancy Balanced energy-protein (BEP) supplementation during pregnancy and lactation can improve birth outcomes and infant growth, with the gut microbiome as a potential mediator. The MISAME-III randomized controlled trial (ClinicalTrial.gov: NCT03533712) assessed the effect of BEP supplementation, provided during pregnancy and the first six months of lactation, on small-for-gestational age prevalence and length-for-age Z-scores at six months in rural Burkina Faso. Nested within MISAME-III, this sub-study examines the impact of BEP supplementation on maternal and infant gut microbiomes and their mediating role in birth outcomes and infant growth. A total of 152 mother-infant dyads (n = 71 intervention, n = 81 control) were included for metagenomic sequencing, with stool samples collected at the second and third trimesters, and at 1–2 and 5–6 months postpartum. BEP supplementation significantly altered maternal gut microbiome diversity, composition, and function, particularly those with immune-modulatory properties. Pathways linked to lipopolysaccharide biosynthesis were depleted and the species Bacteroides fragilis was enriched in BEP-supplemented mothers. Maternal BEP supplementation also accelerated infant microbiome changes and enhanced carbohydrate metabolism. Causal mediation analyses identified specific taxa mediating the effect of BEP on birth outcomes and infant growth. These findings suggest that maternal supplementation modulates gut microbiome composition and influences early-life development in resource-limited settings. 2025-03 2025-03-19T15:38:39Z 2025-03-19T15:38:39Z Journal Article https://hdl.handle.net/10568/173729 en Open Access Springer Deng, Lishi; Taelman, Steff; Olm, Matthew R.; Toe, Laeticia Celine; Balini, Eva; Ouédraogo, Lionel Olivier; et al. 2025. Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial. Nature Communications 16(2025): 2683. https://doi.org/10.1038/s41467-025-57838-y |
| spellingShingle | carbohydrate metabolism infants maternal and child health maternal behaviour microbiomes pregnancy Deng, Lishi Taelman, Steff Olm, Matthew R. Toe, Laeticia Celine Balini, Eva Ouédraogo, Lionel Olivier Bastos-Moreira, Yuri Argaw, Alemayehu Tesfamariam, Kokeb Sonnenburg, Erica D. Hanley-Cook, Giles T. Ouédraogo, Moctar Ganaba, Rasmané Criekinge, Wim Van Huybregts, Lieven Stock, Michiel Kolsteren, Patrick Sonnenburg, Justin L. Lachat, Carl Dailey-Chwalibóg, Trenton Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial |
| title | Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial |
| title_full | Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial |
| title_fullStr | Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial |
| title_full_unstemmed | Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial |
| title_short | Maternal balanced energy-protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants: A randomized controlled trial |
| title_sort | maternal balanced energy protein supplementation reshapes the maternal gut microbiome and enhances carbohydrate metabolism in infants a randomized controlled trial |
| topic | carbohydrate metabolism infants maternal and child health maternal behaviour microbiomes pregnancy |
| url | https://hdl.handle.net/10568/173729 |
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