Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus)
Wheat flour iron (Fe) fortification is mandatory in 75 countries worldwide yet many Fe fortificants, such as Fe-ethylenediaminetetraacetate (EDTA), result in unwanted sensory properties and/or gastrointestinal dysfunction and dysbiosis. Nicotianamine (NA) is a natural chelator of Fe, zinc (Zn) and o...
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2020
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/171248 |
| _version_ | 1855515736804425728 |
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| author | Beasley, Jesse T. Johnson, Alexander A. T. Kolba, Nikolai Bonneau, Julien P. Glahn, Raymond P. Ozeri, Lital Koren, Omry Tako, Elad |
| author_browse | Beasley, Jesse T. Bonneau, Julien P. Glahn, Raymond P. Johnson, Alexander A. T. Kolba, Nikolai Koren, Omry Ozeri, Lital Tako, Elad |
| author_facet | Beasley, Jesse T. Johnson, Alexander A. T. Kolba, Nikolai Bonneau, Julien P. Glahn, Raymond P. Ozeri, Lital Koren, Omry Tako, Elad |
| author_sort | Beasley, Jesse T. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Wheat flour iron (Fe) fortification is mandatory in 75 countries worldwide yet many Fe fortificants, such as Fe-ethylenediaminetetraacetate (EDTA), result in unwanted sensory properties and/or gastrointestinal dysfunction and dysbiosis. Nicotianamine (NA) is a natural chelator of Fe, zinc (Zn) and other metals in higher plants and NA-chelated Fe is highly bioavailable in vitro. In graminaceous plants NA serves as the biosynthetic precursor to 2′ -deoxymugineic acid (DMA), a related Fe chelator and enhancer of Fe bioavailability, and increased NA/DMA biosynthesis has proved an effective Fe biofortification strategy in several cereal crops. Here we utilized the chicken (Gallus gallus) model to investigate impacts of NA-chelated Fe on Fe status and gastrointestinal health when delivered to chickens through intraamniotic administration (short-term exposure) or over a period of six weeks as part of a biofortified wheat diet containing increased NA, Fe, Zn and DMA (long-term exposure). Striking similarities in host Fe status, intestinal functionality and gut microbiome were observed between the short-term and long-term treatments, suggesting that the effects were largely if not entirely due to consumption of NA-chelated Fe. These results provide strong support for wheat with increased NA-chelated Fe as an effective biofortification strategy and uncover novel impacts of NA-chelated Fe on gastrointestinal health and functionality. |
| format | Journal Article |
| id | CGSpace171248 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1712482025-01-29T12:57:54Z Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus) Beasley, Jesse T. Johnson, Alexander A. T. Kolba, Nikolai Bonneau, Julien P. Glahn, Raymond P. Ozeri, Lital Koren, Omry Tako, Elad iron biofortification plate count wheat health zinc Wheat flour iron (Fe) fortification is mandatory in 75 countries worldwide yet many Fe fortificants, such as Fe-ethylenediaminetetraacetate (EDTA), result in unwanted sensory properties and/or gastrointestinal dysfunction and dysbiosis. Nicotianamine (NA) is a natural chelator of Fe, zinc (Zn) and other metals in higher plants and NA-chelated Fe is highly bioavailable in vitro. In graminaceous plants NA serves as the biosynthetic precursor to 2′ -deoxymugineic acid (DMA), a related Fe chelator and enhancer of Fe bioavailability, and increased NA/DMA biosynthesis has proved an effective Fe biofortification strategy in several cereal crops. Here we utilized the chicken (Gallus gallus) model to investigate impacts of NA-chelated Fe on Fe status and gastrointestinal health when delivered to chickens through intraamniotic administration (short-term exposure) or over a period of six weeks as part of a biofortified wheat diet containing increased NA, Fe, Zn and DMA (long-term exposure). Striking similarities in host Fe status, intestinal functionality and gut microbiome were observed between the short-term and long-term treatments, suggesting that the effects were largely if not entirely due to consumption of NA-chelated Fe. These results provide strong support for wheat with increased NA-chelated Fe as an effective biofortification strategy and uncover novel impacts of NA-chelated Fe on gastrointestinal health and functionality. 2020 2025-01-29T12:57:54Z 2025-01-29T12:57:54Z Journal Article https://hdl.handle.net/10568/171248 en Open Access Springer Beasley, Jesse T.; Johnson, Alexander A. T.; Kolba, Nikolai; Bonneau, Julien P.; Glahn, Raymond P.; Ozeri, Lital; Koren, Omry; and Tako, Elad. Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus). Scientific Reports 10: 2297. https://doi.org/10.1038/s41598-020-57598-3 |
| spellingShingle | iron biofortification plate count wheat health zinc Beasley, Jesse T. Johnson, Alexander A. T. Kolba, Nikolai Bonneau, Julien P. Glahn, Raymond P. Ozeri, Lital Koren, Omry Tako, Elad Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus) |
| title | Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus) |
| title_full | Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus) |
| title_fullStr | Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus) |
| title_full_unstemmed | Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus) |
| title_short | Nicotianamine-chelated iron positively affects iron status, intestinal morphology and microbial populations in vivo (Gallus gallus) |
| title_sort | nicotianamine chelated iron positively affects iron status intestinal morphology and microbial populations in vivo gallus gallus |
| topic | iron biofortification plate count wheat health zinc |
| url | https://hdl.handle.net/10568/171248 |
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