Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia
Limited evidence is available on the associations of high-quality protein and energy intake, serum transthyretin (TTR), serum amino acids and serum insulin-like growth factor-1 (IGF-1) with linear growth of young children. Data collected during the baseline of a randomized control trial involving ru...
| Autores principales: | , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/171217 |
| _version_ | 1855534854620315648 |
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| author | Tessema, Masresha Gunaratna, Nilupa S. Brouwer, Inge D. Donato, Katherine Cohen, Jessica L. |
| author_browse | Brouwer, Inge D. Cohen, Jessica L. Donato, Katherine Gunaratna, Nilupa S. Tessema, Masresha |
| author_facet | Tessema, Masresha Gunaratna, Nilupa S. Brouwer, Inge D. Donato, Katherine Cohen, Jessica L. |
| author_sort | Tessema, Masresha |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Limited evidence is available on the associations of high-quality protein and energy intake, serum transthyretin (TTR), serum amino acids and serum insulin-like growth factor-1 (IGF-1) with linear growth of young children. Data collected during the baseline of a randomized control trial involving rural Ethiopian children aged 6–35 months (n = 873) were analyzed to evaluate the associations among height/length-for-age z-scores, dietary intakes, and these biomarkers (i.e., serum level of TTR, IGF-1, tryptophan and lysine, and inflammation). The prevalence of stunting was higher for children >23 months (38%) than ≤23 months (25%). The prevalence of inflammation was 35% and of intestinal parasites 48%. Three-quarters of the children were energy deficient, and stunted children had lower daily energy intake that non-stunted children (p < 0.05). Intakes of tryptophan, protein, and energy, and serum levels of tryptophan and IGF-1 were positively correlated with the linear growth of children. Controlling for inflammation, intestinal parasites, and sociodemographic characteristics, daily tryptophan (b = 0.01, p = 0.001), protein (b = 0.01, p = 0.01) and energy (b = 0.0003, p = 0.04) intakes and serum TTR (b = 2.58, p = 0.04) and IGF-1 (b = 0.01, p = 0.003) were positively associated with linear growth of children. Linear growth failure in Ethiopian children is likely associated with low quality protein intake and inadequate energy intake. Nutrition programs that emphasize improved protein quantity and quality and energy intake may enhance the linear growth of young children and need to be further investigated in longitudinal and interventional studies. |
| format | Journal Article |
| id | CGSpace171217 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | CGSpace1712172025-10-28T10:12:08Z Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia Tessema, Masresha Gunaratna, Nilupa S. Brouwer, Inge D. Donato, Katherine Cohen, Jessica L. quality nutritive value protein quality nutrient intake amino acids growth children blood proteins inflammation linear models Limited evidence is available on the associations of high-quality protein and energy intake, serum transthyretin (TTR), serum amino acids and serum insulin-like growth factor-1 (IGF-1) with linear growth of young children. Data collected during the baseline of a randomized control trial involving rural Ethiopian children aged 6–35 months (n = 873) were analyzed to evaluate the associations among height/length-for-age z-scores, dietary intakes, and these biomarkers (i.e., serum level of TTR, IGF-1, tryptophan and lysine, and inflammation). The prevalence of stunting was higher for children >23 months (38%) than ≤23 months (25%). The prevalence of inflammation was 35% and of intestinal parasites 48%. Three-quarters of the children were energy deficient, and stunted children had lower daily energy intake that non-stunted children (p < 0.05). Intakes of tryptophan, protein, and energy, and serum levels of tryptophan and IGF-1 were positively correlated with the linear growth of children. Controlling for inflammation, intestinal parasites, and sociodemographic characteristics, daily tryptophan (b = 0.01, p = 0.001), protein (b = 0.01, p = 0.01) and energy (b = 0.0003, p = 0.04) intakes and serum TTR (b = 2.58, p = 0.04) and IGF-1 (b = 0.01, p = 0.003) were positively associated with linear growth of children. Linear growth failure in Ethiopian children is likely associated with low quality protein intake and inadequate energy intake. Nutrition programs that emphasize improved protein quantity and quality and energy intake may enhance the linear growth of young children and need to be further investigated in longitudinal and interventional studies. 2018 2025-01-29T12:57:52Z 2025-01-29T12:57:52Z Journal Article https://hdl.handle.net/10568/171217 en Open Access MDPI Tessema, Masresha; Gunaratna, Nilupa S.; Brouwer, Inge D.; Donato, Katherine; Cohen, Jessica L.; et al. 2018. Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia. Nutrients 10(11): 1776. https://doi.org/10.3390/nu10111776 |
| spellingShingle | quality nutritive value protein quality nutrient intake amino acids growth children blood proteins inflammation linear models Tessema, Masresha Gunaratna, Nilupa S. Brouwer, Inge D. Donato, Katherine Cohen, Jessica L. Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia |
| title | Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia |
| title_full | Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia |
| title_fullStr | Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia |
| title_full_unstemmed | Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia |
| title_short | Associations among high-quality protein and energy intake, serum transthyretin, serim amino acids and linear growth in children of Ethiopia |
| title_sort | associations among high quality protein and energy intake serum transthyretin serim amino acids and linear growth in children of ethiopia |
| topic | quality nutritive value protein quality nutrient intake amino acids growth children blood proteins inflammation linear models |
| url | https://hdl.handle.net/10568/171217 |
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