Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments
Antimicrobial resistance (AMR) data from agroecosystems in low- and middle-income countries is limited. We surveyed chicken (n = 52) and pig (n = 47) farms in Kenya to understand AMR in animal-environment pathways. Using LC-MS/MS, we validated the methods for analyzing eight common antibiotics and q...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Nature Research
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/168461 |
| _version_ | 1855536968707866624 |
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| author | Gudda, Fredrick Muloi, Dishon Nganga, Fredrick Nolari, Cynthia Gao, Y. Moodley, Arshnee |
| author_browse | Gao, Y. Gudda, Fredrick Moodley, Arshnee Muloi, Dishon Nganga, Fredrick Nolari, Cynthia |
| author_facet | Gudda, Fredrick Muloi, Dishon Nganga, Fredrick Nolari, Cynthia Gao, Y. Moodley, Arshnee |
| author_sort | Gudda, Fredrick |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Antimicrobial resistance (AMR) data from agroecosystems in low- and middle-income countries is limited. We surveyed chicken (n = 52) and pig (n = 47) farms in Kenya to understand AMR in animal-environment pathways. Using LC-MS/MS, we validated the methods for analyzing eight common antibiotics and quantified the associated risks. Chicken compost (25.8%, n = 97/376) had the highest antibiotics prevalence, followed by pig manure-fertilized soils (23.1%, n = 83/360). The average antibiotic concentration was 63.4 µg/kg, which is below the environmentally relevant threshold (100 µg/kg), except for trimethoprim (221.4 µg/kg) among antibiotics and pig manure-fertilized soils (129.3 µg/kg) across sample types. Similarly, the average AMR risk quotient (RQ) was low (RQ < 0.1), except for trimethoprim and sulfamethoxazole (RQ ≥ 1). Ecotoxicity and AMR risks increased with flock size and the number of antibiotics used by pigs. Continuous environmental monitoring and large-scale studies on antibiotic contamination are crucial for evidence-based pollution control and the effective mitigation of environmental AMR. |
| format | Journal Article |
| id | CGSpace168461 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Nature Research |
| publisherStr | Nature Research |
| record_format | dspace |
| spelling | CGSpace1684612025-10-26T12:55:57Z Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments Gudda, Fredrick Muloi, Dishon Nganga, Fredrick Nolari, Cynthia Gao, Y. Moodley, Arshnee antimicrobial resistance poultry swine Antimicrobial resistance (AMR) data from agroecosystems in low- and middle-income countries is limited. We surveyed chicken (n = 52) and pig (n = 47) farms in Kenya to understand AMR in animal-environment pathways. Using LC-MS/MS, we validated the methods for analyzing eight common antibiotics and quantified the associated risks. Chicken compost (25.8%, n = 97/376) had the highest antibiotics prevalence, followed by pig manure-fertilized soils (23.1%, n = 83/360). The average antibiotic concentration was 63.4 µg/kg, which is below the environmentally relevant threshold (100 µg/kg), except for trimethoprim (221.4 µg/kg) among antibiotics and pig manure-fertilized soils (129.3 µg/kg) across sample types. Similarly, the average AMR risk quotient (RQ) was low (RQ < 0.1), except for trimethoprim and sulfamethoxazole (RQ ≥ 1). Ecotoxicity and AMR risks increased with flock size and the number of antibiotics used by pigs. Continuous environmental monitoring and large-scale studies on antibiotic contamination are crucial for evidence-based pollution control and the effective mitigation of environmental AMR. 2024-12-30 2025-01-02T06:50:25Z 2025-01-02T06:50:25Z Journal Article https://hdl.handle.net/10568/168461 en Open Access Nature Research Gudda, F., Muloi, D., Nganga, F., Nolari, C., Gao, Y. and Moodley, A. 2024. Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments. npj Antimicrobials and Resistance 2: 51. |
| spellingShingle | antimicrobial resistance poultry swine Gudda, Fredrick Muloi, Dishon Nganga, Fredrick Nolari, Cynthia Gao, Y. Moodley, Arshnee Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments |
| title | Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments |
| title_full | Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments |
| title_fullStr | Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments |
| title_full_unstemmed | Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments |
| title_short | Antibiotic ecotoxicity and resistance risks in resource-constrained chicken and pig farming environments |
| title_sort | antibiotic ecotoxicity and resistance risks in resource constrained chicken and pig farming environments |
| topic | antimicrobial resistance poultry swine |
| url | https://hdl.handle.net/10568/168461 |
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