Mapping QTL for multiple traits using Bayesian statistics
The value of a new crop species is usually judged by the overall performance of multiple traits. Therefore, in most quantitative trait locus (QTL) mapping experiments, researchers tend to collect phenotypic records for multiple traits. Some traits may vary continuously and others may vary in a discr...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Hindawi Limited
2009
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/166210 |
| _version_ | 1855543306831790080 |
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| author | Xu, Chenwu Wang, Xuefeng Li, Zhikang Xu, Shizhong |
| author_browse | Li, Zhikang Wang, Xuefeng Xu, Chenwu Xu, Shizhong |
| author_facet | Xu, Chenwu Wang, Xuefeng Li, Zhikang Xu, Shizhong |
| author_sort | Xu, Chenwu |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The value of a new crop species is usually judged by the overall performance of multiple traits. Therefore, in most quantitative trait locus (QTL) mapping experiments, researchers tend to collect phenotypic records for multiple traits. Some traits may vary continuously and others may vary in a discrete fashion. Although mapping QTLs jointly for multiple traits is more efficient than mapping QTLs separately for individual traits, the latter is still commonly practised in QTL mapping. This is primarily due to the lack of efficient statistical methods and computer software packages to implement the methods. Mapping multiple QTLs simultaneously in a single multivariate model has not been available, especially when categorical traits are involved. In the present study, we developed a Bayesian method to map QTLs of the entire genome for multiple traits with continuous, discrete or both types of phenotypic distribution. Instead of using the reversible jump Markov chain Monte Carlo (MCMC) for model selection, we adopt a parameter shrinkage approach to estimate the genetic effects of all marker intervals. We demonstrate the method by analysing a set of simulated data with both continuous and discrete traits. We also apply the method to mapping QTLs responsible for multiple disease resistances to the blast fungus of rice. A computer program written in SAS/IML that implements the method is freely available, on request, to academic researchers. |
| format | Journal Article |
| id | CGSpace166210 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2009 |
| publishDateRange | 2009 |
| publishDateSort | 2009 |
| publisher | Hindawi Limited |
| publisherStr | Hindawi Limited |
| record_format | dspace |
| spelling | CGSpace1662102026-01-05T13:39:57Z Mapping QTL for multiple traits using Bayesian statistics Xu, Chenwu Wang, Xuefeng Li, Zhikang Xu, Shizhong disease resistance genetic mapping genetic resistance genomes quantitative trait loci simulation models The value of a new crop species is usually judged by the overall performance of multiple traits. Therefore, in most quantitative trait locus (QTL) mapping experiments, researchers tend to collect phenotypic records for multiple traits. Some traits may vary continuously and others may vary in a discrete fashion. Although mapping QTLs jointly for multiple traits is more efficient than mapping QTLs separately for individual traits, the latter is still commonly practised in QTL mapping. This is primarily due to the lack of efficient statistical methods and computer software packages to implement the methods. Mapping multiple QTLs simultaneously in a single multivariate model has not been available, especially when categorical traits are involved. In the present study, we developed a Bayesian method to map QTLs of the entire genome for multiple traits with continuous, discrete or both types of phenotypic distribution. Instead of using the reversible jump Markov chain Monte Carlo (MCMC) for model selection, we adopt a parameter shrinkage approach to estimate the genetic effects of all marker intervals. We demonstrate the method by analysing a set of simulated data with both continuous and discrete traits. We also apply the method to mapping QTLs responsible for multiple disease resistances to the blast fungus of rice. A computer program written in SAS/IML that implements the method is freely available, on request, to academic researchers. 2009-02 2024-12-19T12:56:00Z 2024-12-19T12:56:00Z Journal Article https://hdl.handle.net/10568/166210 en Hindawi Limited XU, CHENWU; WANG, XUEFENG; LI, ZHIKANG and XU, SHIZHONG. 2009. Mapping QTL for multiple traits using Bayesian statistics. Genet. Res., Volume 91 no. 1 p. 23-37 |
| spellingShingle | disease resistance genetic mapping genetic resistance genomes quantitative trait loci simulation models Xu, Chenwu Wang, Xuefeng Li, Zhikang Xu, Shizhong Mapping QTL for multiple traits using Bayesian statistics |
| title | Mapping QTL for multiple traits using Bayesian statistics |
| title_full | Mapping QTL for multiple traits using Bayesian statistics |
| title_fullStr | Mapping QTL for multiple traits using Bayesian statistics |
| title_full_unstemmed | Mapping QTL for multiple traits using Bayesian statistics |
| title_short | Mapping QTL for multiple traits using Bayesian statistics |
| title_sort | mapping qtl for multiple traits using bayesian statistics |
| topic | disease resistance genetic mapping genetic resistance genomes quantitative trait loci simulation models |
| url | https://hdl.handle.net/10568/166210 |
| work_keys_str_mv | AT xuchenwu mappingqtlformultipletraitsusingbayesianstatistics AT wangxuefeng mappingqtlformultipletraitsusingbayesianstatistics AT lizhikang mappingqtlformultipletraitsusingbayesianstatistics AT xushizhong mappingqtlformultipletraitsusingbayesianstatistics |