Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice
Brassinosteroids (BRs) are a unique class of plant steroid hormones that orchestrate myriad growth and developmental processes. Although BRs have long been known to protect plants from a suite of biotic and abiotic stresses, our understanding of the underlying molecular mechanisms is still rudimenta...
| Autores principales: | , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/165799 |
| _version_ | 1855515417759449088 |
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| author | De Vleesschauwer, David Van Buyten, Evelien Satoh, Kouji Balidion, Johny Mauleon, Ramil Choi, Il-Ryong Vera Cruz, Casiana Kikuchi, Shoshi Höfte, Monica |
| author_browse | Balidion, Johny Choi, Il-Ryong De Vleesschauwer, David Höfte, Monica Kikuchi, Shoshi Mauleon, Ramil Satoh, Kouji Van Buyten, Evelien Vera Cruz, Casiana |
| author_facet | De Vleesschauwer, David Van Buyten, Evelien Satoh, Kouji Balidion, Johny Mauleon, Ramil Choi, Il-Ryong Vera Cruz, Casiana Kikuchi, Shoshi Höfte, Monica |
| author_sort | De Vleesschauwer, David |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Brassinosteroids (BRs) are a unique class of plant steroid hormones that orchestrate myriad growth and developmental processes. Although BRs have long been known to protect plants from a suite of biotic and abiotic stresses, our understanding of the underlying molecular mechanisms is still rudimentary. Aiming to further decipher the molecular logic of BR-modulated immunity, we have examined the dynamics and impact of BRs during infection of rice (Oryza sativa) with the root oomycete Pythium graminicola. Challenging the prevailing view that BRs positively regulate plant innate immunity, we show that P. graminicola exploits BRs as virulence factors and hijacks the rice BR machinery to inflict disease. Moreover, we demonstrate that this immune-suppressive effect of BRs is due, at least in part, to negative cross talk with salicylic acid (SA) and gibberellic acid (GA) pathways. BR-mediated suppression of SA defenses occurred downstream of SA biosynthesis, but upstream of the master defense regulators NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and OsWRKY45. In contrast, BR alleviated GA-directed immune responses by interfering at multiple levels with GA metabolism, resulting in indirect stabilization of the DELLA protein and central GA repressor SLENDER RICE1 (SLR1). Collectively, these data favor a model whereby P. graminicola coopts the plant BR pathway as a decoy to antagonize effectual SA- and GA-mediated defenses. Our results highlight the importance of BRs in modulating plant immunity and uncover pathogen-mediated manipulation of plant steroid homeostasis as a core virulence strategy. |
| format | Journal Article |
| id | CGSpace165799 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace1657992025-05-14T10:23:52Z Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice De Vleesschauwer, David Van Buyten, Evelien Satoh, Kouji Balidion, Johny Mauleon, Ramil Choi, Il-Ryong Vera Cruz, Casiana Kikuchi, Shoshi Höfte, Monica brassinosteroids disease resistance fungi gibberellic acid pathogens plant growth substances plant pathogenic fungi roots salicylic acid virulence Brassinosteroids (BRs) are a unique class of plant steroid hormones that orchestrate myriad growth and developmental processes. Although BRs have long been known to protect plants from a suite of biotic and abiotic stresses, our understanding of the underlying molecular mechanisms is still rudimentary. Aiming to further decipher the molecular logic of BR-modulated immunity, we have examined the dynamics and impact of BRs during infection of rice (Oryza sativa) with the root oomycete Pythium graminicola. Challenging the prevailing view that BRs positively regulate plant innate immunity, we show that P. graminicola exploits BRs as virulence factors and hijacks the rice BR machinery to inflict disease. Moreover, we demonstrate that this immune-suppressive effect of BRs is due, at least in part, to negative cross talk with salicylic acid (SA) and gibberellic acid (GA) pathways. BR-mediated suppression of SA defenses occurred downstream of SA biosynthesis, but upstream of the master defense regulators NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and OsWRKY45. In contrast, BR alleviated GA-directed immune responses by interfering at multiple levels with GA metabolism, resulting in indirect stabilization of the DELLA protein and central GA repressor SLENDER RICE1 (SLR1). Collectively, these data favor a model whereby P. graminicola coopts the plant BR pathway as a decoy to antagonize effectual SA- and GA-mediated defenses. Our results highlight the importance of BRs in modulating plant immunity and uncover pathogen-mediated manipulation of plant steroid homeostasis as a core virulence strategy. 2012-04-02 2024-12-19T12:55:30Z 2024-12-19T12:55:30Z Journal Article https://hdl.handle.net/10568/165799 en Open Access Oxford University Press De Vleesschauwer, David; Van Buyten, Evelien; Satoh, Kouji; Balidion, Johny; Mauleon, Ramil; Choi, Il-Ryong; Vera-Cruz, Casiana; Kikuchi, Shoshi and Höfte, Monica. 2012. Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice. Plant Physiology, Volume 158, no. 4, pages 1833-1846, ill. Ref. Apr. |
| spellingShingle | brassinosteroids disease resistance fungi gibberellic acid pathogens plant growth substances plant pathogenic fungi roots salicylic acid virulence De Vleesschauwer, David Van Buyten, Evelien Satoh, Kouji Balidion, Johny Mauleon, Ramil Choi, Il-Ryong Vera Cruz, Casiana Kikuchi, Shoshi Höfte, Monica Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice |
| title | Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice |
| title_full | Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice |
| title_fullStr | Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice |
| title_full_unstemmed | Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice |
| title_short | Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice |
| title_sort | brassinosteroids antagonize gibberellin and salicylate mediated root immunity in rice |
| topic | brassinosteroids disease resistance fungi gibberellic acid pathogens plant growth substances plant pathogenic fungi roots salicylic acid virulence |
| url | https://hdl.handle.net/10568/165799 |
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