DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses
DNA (class 2) transposons are mobile genetic elements which move within their ‘host’ genome through excising and re-inserting elsewhere. Although the rice genome contains tens of thousands of such elements, their actual role in evolution is still unclear. Analysing over 650 transposon polymorphisms...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Springer
2016
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| Online Access: | https://hdl.handle.net/10568/165214 |
| _version_ | 1855526897065132032 |
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| author | Wicker, Thomas Yu, Yeisoo Haberer, Georg Mayer, Klaus F. X. Marri, Pradeep Reddy Rounsley, Steve Chen, Mingsheng Zuccolo, Andrea Panaud, Olivier Wing, Rod A. Roffler, Stefan |
| author_browse | Chen, Mingsheng Haberer, Georg Marri, Pradeep Reddy Mayer, Klaus F. X. Panaud, Olivier Roffler, Stefan Rounsley, Steve Wicker, Thomas Wing, Rod A. Yu, Yeisoo Zuccolo, Andrea |
| author_facet | Wicker, Thomas Yu, Yeisoo Haberer, Georg Mayer, Klaus F. X. Marri, Pradeep Reddy Rounsley, Steve Chen, Mingsheng Zuccolo, Andrea Panaud, Olivier Wing, Rod A. Roffler, Stefan |
| author_sort | Wicker, Thomas |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | DNA (class 2) transposons are mobile genetic elements which move within their ‘host’ genome through excising and re-inserting elsewhere. Although the rice genome contains tens of thousands of such elements, their actual role in evolution is still unclear. Analysing over 650 transposon polymorphisms in the rice species Oryza sativa and Oryza glaberrima, we find that DNA repair following transposon excisions is associated with an increased number of mutations in the sequences neighbouring the transposon. Indeed, the 3,000 bp flanking the excised transposons can contain over 10 times more mutations than the genome-wide average. Since DNA transposons preferably insert near genes, this is correlated with increases in mutation rates in coding sequences and regulatory regions. Most importantly, we find this phenomenon also in maize, wheat and barley. Thus, these findings suggest that DNA transposon activity is a major evolutionary force in grasses which provide the basis of most food consumed by humankind. |
| format | Journal Article |
| id | CGSpace165214 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1652142024-12-19T14:12:43Z DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses Wicker, Thomas Yu, Yeisoo Haberer, Georg Mayer, Klaus F. X. Marri, Pradeep Reddy Rounsley, Steve Chen, Mingsheng Zuccolo, Andrea Panaud, Olivier Wing, Rod A. Roffler, Stefan DNA (class 2) transposons are mobile genetic elements which move within their ‘host’ genome through excising and re-inserting elsewhere. Although the rice genome contains tens of thousands of such elements, their actual role in evolution is still unclear. Analysing over 650 transposon polymorphisms in the rice species Oryza sativa and Oryza glaberrima, we find that DNA repair following transposon excisions is associated with an increased number of mutations in the sequences neighbouring the transposon. Indeed, the 3,000 bp flanking the excised transposons can contain over 10 times more mutations than the genome-wide average. Since DNA transposons preferably insert near genes, this is correlated with increases in mutation rates in coding sequences and regulatory regions. Most importantly, we find this phenomenon also in maize, wheat and barley. Thus, these findings suggest that DNA transposon activity is a major evolutionary force in grasses which provide the basis of most food consumed by humankind. 2016-09-07 2024-12-19T12:54:49Z 2024-12-19T12:54:49Z Journal Article https://hdl.handle.net/10568/165214 en Open Access Springer Wicker, Thomas; Yu, Yeisoo; Haberer, Georg; Mayer, Klaus F. X.; Marri, Pradeep Reddy; Rounsley, Steve; Chen, Mingsheng; Zuccolo, Andrea; Panaud, Olivier; Wing, Rod A. and Roffler, Stefan. 2016. DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses. Nat Commun, Volume 7, no. 1 |
| spellingShingle | Wicker, Thomas Yu, Yeisoo Haberer, Georg Mayer, Klaus F. X. Marri, Pradeep Reddy Rounsley, Steve Chen, Mingsheng Zuccolo, Andrea Panaud, Olivier Wing, Rod A. Roffler, Stefan DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses |
| title | DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses |
| title_full | DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses |
| title_fullStr | DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses |
| title_full_unstemmed | DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses |
| title_short | DNA transposon activity is associated with increased mutation rates in genes of rice and other grasses |
| title_sort | dna transposon activity is associated with increased mutation rates in genes of rice and other grasses |
| url | https://hdl.handle.net/10568/165214 |
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