Broad-spectrum resistance to bacterial blight in rice using genome editing

Bacterial blight of rice is an important disease in Asia and Africa. The pathogen,Xanthomonas oryzaepv.oryzae(Xoo), secretes one or more of six known transcription-activator-like effectors (TALes) that bind specific promoter sequences and induce, at minimum, one of the three host sucrose transporter...

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Autores principales: Oliva, Ricardo, Ji, Chonghui, Atienza-Grande, Genelou, Huguet-Tapia, José C., Perez-Quintero, Alvaro, Li, Ting, Eom, Joon-Seob, Li, Chenhao, Nguyen, Hanna, Liu, Bo, Auguy, Florence, Sciallano, Coline, Luu, Van T., Dossa, Gerbert S., Cunnac, Sébastien, Schmidt, Sarah M., Slamet-Loedin, Inez H., Vera Cruz, Casiana, Szurek, Boris, Frommer, Wolf B., White, Frank F., Yang, Bing
Formato: Journal Article
Lenguaje:Inglés
Publicado: Springer 2019
Materias:
Acceso en línea:https://hdl.handle.net/10568/164605
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author Oliva, Ricardo
Ji, Chonghui
Atienza-Grande, Genelou
Huguet-Tapia, José C.
Perez-Quintero, Alvaro
Li, Ting
Eom, Joon-Seob
Li, Chenhao
Nguyen, Hanna
Liu, Bo
Auguy, Florence
Sciallano, Coline
Luu, Van T.
Dossa, Gerbert S.
Cunnac, Sébastien
Schmidt, Sarah M.
Slamet-Loedin, Inez H.
Vera Cruz, Casiana
Szurek, Boris
Frommer, Wolf B.
White, Frank F.
Yang, Bing
author_browse Atienza-Grande, Genelou
Auguy, Florence
Cunnac, Sébastien
Dossa, Gerbert S.
Eom, Joon-Seob
Frommer, Wolf B.
Huguet-Tapia, José C.
Ji, Chonghui
Li, Chenhao
Li, Ting
Liu, Bo
Luu, Van T.
Nguyen, Hanna
Oliva, Ricardo
Perez-Quintero, Alvaro
Schmidt, Sarah M.
Sciallano, Coline
Slamet-Loedin, Inez H.
Szurek, Boris
Vera Cruz, Casiana
White, Frank F.
Yang, Bing
author_facet Oliva, Ricardo
Ji, Chonghui
Atienza-Grande, Genelou
Huguet-Tapia, José C.
Perez-Quintero, Alvaro
Li, Ting
Eom, Joon-Seob
Li, Chenhao
Nguyen, Hanna
Liu, Bo
Auguy, Florence
Sciallano, Coline
Luu, Van T.
Dossa, Gerbert S.
Cunnac, Sébastien
Schmidt, Sarah M.
Slamet-Loedin, Inez H.
Vera Cruz, Casiana
Szurek, Boris
Frommer, Wolf B.
White, Frank F.
Yang, Bing
author_sort Oliva, Ricardo
collection Repository of Agricultural Research Outputs (CGSpace)
description Bacterial blight of rice is an important disease in Asia and Africa. The pathogen,Xanthomonas oryzaepv.oryzae(Xoo), secretes one or more of six known transcription-activator-like effectors (TALes) that bind specific promoter sequences and induce, at minimum, one of the three host sucrose transporter genesSWEET11,SWEET13andSWEET14, the expression of which is required for disease susceptibility. We used CRISPR–Cas9-mediated genome editing to introduce mutations in all threeSWEETgene promoters. Editing was further informed by sequence analyses of TALe genes in 63Xoostrains, which revealed multiple TALe variants forSWEET13alleles. Mutations were also created inSWEET14, which is also targeted by two TALes from an AfricanXoolineage. A total of five promoter mutations were simultaneously introduced into the rice line Kitaake and the elite mega varieties IR64 and Ciherang-Sub1. Paddy trials showed that genome-editedSWEETpromoters endow rice lines with robust, broad-spectrum resistance.
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spelling CGSpace1646052024-12-19T14:11:48Z Broad-spectrum resistance to bacterial blight in rice using genome editing Oliva, Ricardo Ji, Chonghui Atienza-Grande, Genelou Huguet-Tapia, José C. Perez-Quintero, Alvaro Li, Ting Eom, Joon-Seob Li, Chenhao Nguyen, Hanna Liu, Bo Auguy, Florence Sciallano, Coline Luu, Van T. Dossa, Gerbert S. Cunnac, Sébastien Schmidt, Sarah M. Slamet-Loedin, Inez H. Vera Cruz, Casiana Szurek, Boris Frommer, Wolf B. White, Frank F. Yang, Bing applied microbiology and biotechnology bioengineering biomedical engineering biotechnology molecular medicine Bacterial blight of rice is an important disease in Asia and Africa. The pathogen,Xanthomonas oryzaepv.oryzae(Xoo), secretes one or more of six known transcription-activator-like effectors (TALes) that bind specific promoter sequences and induce, at minimum, one of the three host sucrose transporter genesSWEET11,SWEET13andSWEET14, the expression of which is required for disease susceptibility. We used CRISPR–Cas9-mediated genome editing to introduce mutations in all threeSWEETgene promoters. Editing was further informed by sequence analyses of TALe genes in 63Xoostrains, which revealed multiple TALe variants forSWEET13alleles. Mutations were also created inSWEET14, which is also targeted by two TALes from an AfricanXoolineage. A total of five promoter mutations were simultaneously introduced into the rice line Kitaake and the elite mega varieties IR64 and Ciherang-Sub1. Paddy trials showed that genome-editedSWEETpromoters endow rice lines with robust, broad-spectrum resistance. 2019-11 2024-12-19T12:54:06Z 2024-12-19T12:54:06Z Journal Article https://hdl.handle.net/10568/164605 en Open Access Springer Oliva, Ricardo; Ji, Chonghui; Atienza-Grande, Genelou; Huguet-Tapia, José C.; Perez-Quintero, Alvaro; Li, Ting; Eom, Joon-Seob; Li, Chenhao; Nguyen, Hanna; Liu, Bo; Auguy, Florence; Sciallano, Coline; Luu, Van T.; Dossa, Gerbert S.; Cunnac, Sébastien; Schmidt, Sarah M.; Slamet-Loedin, Inez H.; Vera Cruz, Casiana; Szurek, Boris; Frommer, Wolf B.; White, Frank F. and Yang, Bing. 2019. Broad-spectrum resistance to bacterial blight in rice using genome editing. Nat Biotechnol, Volume 37 no. 11 p. 1344-1350
spellingShingle applied microbiology and biotechnology
bioengineering
biomedical engineering
biotechnology
molecular medicine
Oliva, Ricardo
Ji, Chonghui
Atienza-Grande, Genelou
Huguet-Tapia, José C.
Perez-Quintero, Alvaro
Li, Ting
Eom, Joon-Seob
Li, Chenhao
Nguyen, Hanna
Liu, Bo
Auguy, Florence
Sciallano, Coline
Luu, Van T.
Dossa, Gerbert S.
Cunnac, Sébastien
Schmidt, Sarah M.
Slamet-Loedin, Inez H.
Vera Cruz, Casiana
Szurek, Boris
Frommer, Wolf B.
White, Frank F.
Yang, Bing
Broad-spectrum resistance to bacterial blight in rice using genome editing
title Broad-spectrum resistance to bacterial blight in rice using genome editing
title_full Broad-spectrum resistance to bacterial blight in rice using genome editing
title_fullStr Broad-spectrum resistance to bacterial blight in rice using genome editing
title_full_unstemmed Broad-spectrum resistance to bacterial blight in rice using genome editing
title_short Broad-spectrum resistance to bacterial blight in rice using genome editing
title_sort broad spectrum resistance to bacterial blight in rice using genome editing
topic applied microbiology and biotechnology
bioengineering
biomedical engineering
biotechnology
molecular medicine
url https://hdl.handle.net/10568/164605
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