Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP
While much work has been done in associating differentially methylated positions (DMPs) to type 2 diabetes (T2D) across different populations, not much attention has been placed on identifying its possible functional consequences. We explored methylation changes in the peripheral blood of Filipinos...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/164601 |
| _version_ | 1855530355060113408 |
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| author | Albao, Dominic S. Cutiongco-de la Paz, Eva Maria Mercado, Maria Elizabeth Lirio, Alvin Mariano, Margarette Kim, Sarah Yangco, Ariane Melegrito, Jodelyn Wad-asen, Kate Gauran, Iris Ivy Francisco, Marie Angeline Santos-Acuin, Cecilia David-Padilla, Carmencita Murphy, Elizabeth J. Paz-Pacheco, Elizabeth Seielstad, Mark |
| author_browse | Albao, Dominic S. Cutiongco-de la Paz, Eva Maria David-Padilla, Carmencita Francisco, Marie Angeline Gauran, Iris Ivy Kim, Sarah Lirio, Alvin Mariano, Margarette Melegrito, Jodelyn Mercado, Maria Elizabeth Murphy, Elizabeth J. Paz-Pacheco, Elizabeth Santos-Acuin, Cecilia Seielstad, Mark Wad-asen, Kate Yangco, Ariane |
| author_facet | Albao, Dominic S. Cutiongco-de la Paz, Eva Maria Mercado, Maria Elizabeth Lirio, Alvin Mariano, Margarette Kim, Sarah Yangco, Ariane Melegrito, Jodelyn Wad-asen, Kate Gauran, Iris Ivy Francisco, Marie Angeline Santos-Acuin, Cecilia David-Padilla, Carmencita Murphy, Elizabeth J. Paz-Pacheco, Elizabeth Seielstad, Mark |
| author_sort | Albao, Dominic S. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | While much work has been done in associating differentially methylated positions (DMPs) to type 2 diabetes (T2D) across different populations, not much attention has been placed on identifying its possible functional consequences. We explored methylation changes in the peripheral blood of Filipinos with T2D and identified 177 associated DMPs. Most of these DMPs were associated with genes involved in metabolism, inflammation and the cell cycle. Three of these DMPs map to the TXNIP gene body, replicating previous findings from epigenome-wide association studies (EWAS) of T2D. The TXNIP downmethylation coincided with increased transcription at the 3’-UTR, H3K36me3 histone markings, and Sp1 binding, suggesting spurious transcription initiation at the TXNIP 3’-UTR as a functional consequence of T2D methylation changes. We also explored potential epigenetic determinants to increased incidence of T2D in Filipino immigrants in the United States and found 3 DMPs associated with the interaction of T2D and immigration. Two of these DMPs were located near MAP 2 K7 and PRMT1, which may point towards dysregulated stress response and inflammation as a contributing factor to T2D among Filipino immigrants. |
| format | Journal Article |
| id | CGSpace164601 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace1646012025-05-14T10:24:16Z Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP Albao, Dominic S. Cutiongco-de la Paz, Eva Maria Mercado, Maria Elizabeth Lirio, Alvin Mariano, Margarette Kim, Sarah Yangco, Ariane Melegrito, Jodelyn Wad-asen, Kate Gauran, Iris Ivy Francisco, Marie Angeline Santos-Acuin, Cecilia David-Padilla, Carmencita Murphy, Elizabeth J. Paz-Pacheco, Elizabeth Seielstad, Mark general medicine genetics genetics(clinical) molecular biology While much work has been done in associating differentially methylated positions (DMPs) to type 2 diabetes (T2D) across different populations, not much attention has been placed on identifying its possible functional consequences. We explored methylation changes in the peripheral blood of Filipinos with T2D and identified 177 associated DMPs. Most of these DMPs were associated with genes involved in metabolism, inflammation and the cell cycle. Three of these DMPs map to the TXNIP gene body, replicating previous findings from epigenome-wide association studies (EWAS) of T2D. The TXNIP downmethylation coincided with increased transcription at the 3’-UTR, H3K36me3 histone markings, and Sp1 binding, suggesting spurious transcription initiation at the TXNIP 3’-UTR as a functional consequence of T2D methylation changes. We also explored potential epigenetic determinants to increased incidence of T2D in Filipino immigrants in the United States and found 3 DMPs associated with the interaction of T2D and immigration. Two of these DMPs were located near MAP 2 K7 and PRMT1, which may point towards dysregulated stress response and inflammation as a contributing factor to T2D among Filipino immigrants. 2019-11-06 2024-12-19T12:54:06Z 2024-12-19T12:54:06Z Journal Article https://hdl.handle.net/10568/164601 en Oxford University Press Albao, Dominic S; Cutiongco-de la Paz, Eva Maria; Mercado, Maria Elizabeth; Lirio, Alvin; Mariano, Margarette; Kim, Sarah; Yangco, Ariane; Melegrito, Jodelyn; Wad-asen, Kate; Gauran, Iris Ivy; Francisco, Marie Angeline; Santos-Acuin, Cecilia; David-Padilla, Carmencita; Murphy, Elizabeth J; Paz-Pacheco, Elizabeth and Seielstad, Mark. 2019. Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP. Human Molecular Genetics, Volume 28, no. 24; pages 4209-4218. |
| spellingShingle | general medicine genetics genetics(clinical) molecular biology Albao, Dominic S. Cutiongco-de la Paz, Eva Maria Mercado, Maria Elizabeth Lirio, Alvin Mariano, Margarette Kim, Sarah Yangco, Ariane Melegrito, Jodelyn Wad-asen, Kate Gauran, Iris Ivy Francisco, Marie Angeline Santos-Acuin, Cecilia David-Padilla, Carmencita Murphy, Elizabeth J. Paz-Pacheco, Elizabeth Seielstad, Mark Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP |
| title | Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP |
| title_full | Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP |
| title_fullStr | Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP |
| title_full_unstemmed | Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP |
| title_short | Methylation changes in the peripheral blood of Filipinos with type 2 diabetes suggest spurious transcription initiation at TXNIP |
| title_sort | methylation changes in the peripheral blood of filipinos with type 2 diabetes suggest spurious transcription initiation at txnip |
| topic | general medicine genetics genetics(clinical) molecular biology |
| url | https://hdl.handle.net/10568/164601 |
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