The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition
Brown rice (Oryza sativa) possesses various nutritionally dense bioactive phytochemicals exhibiting a wide range of antioxidant, anti‐cancer, and anti‐diabetic properties known to promote various human health benefits. However, despite the wide claims made about the importance of brown rice for huma...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2021
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| Acceso en línea: | https://hdl.handle.net/10568/164316 |
| _version_ | 1855540735398379520 |
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| author | Brotman, Yariv Llorente-Wiegand, Cindy Oyong, Glenn Badoni, Saurabh Misra, Gopal Anacleto, Roslen Parween, Sabiha Pasion, Erstelle Tiozon, Rhowell N. Anonuevo, Joanne J. deGuzman, Maria K. Alseekh, Saleh Mbanjo, Edwige G. N. Boyd, Lesley A. Fernie, Alisdair R. Sreenivasulu, Nese |
| author_browse | Alseekh, Saleh Anacleto, Roslen Anonuevo, Joanne J. Badoni, Saurabh Boyd, Lesley A. Brotman, Yariv Fernie, Alisdair R. Llorente-Wiegand, Cindy Mbanjo, Edwige G. N. Misra, Gopal Oyong, Glenn Parween, Sabiha Pasion, Erstelle Sreenivasulu, Nese Tiozon, Rhowell N. deGuzman, Maria K. |
| author_facet | Brotman, Yariv Llorente-Wiegand, Cindy Oyong, Glenn Badoni, Saurabh Misra, Gopal Anacleto, Roslen Parween, Sabiha Pasion, Erstelle Tiozon, Rhowell N. Anonuevo, Joanne J. deGuzman, Maria K. Alseekh, Saleh Mbanjo, Edwige G. N. Boyd, Lesley A. Fernie, Alisdair R. Sreenivasulu, Nese |
| author_sort | Brotman, Yariv |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Brown rice (Oryza sativa) possesses various nutritionally dense bioactive phytochemicals exhibiting a wide range of antioxidant, anti‐cancer, and anti‐diabetic properties known to promote various human health benefits. However, despite the wide claims made about the importance of brown rice for human nutrition the underlying metabolic diversity has not been systematically explored. Non‐targeted metabolite profiling of developing and mature seeds of a diverse genetic panel of 320 rice cultivars allowed quantification of 117 metabolites. The metabolite genome‐wide association study (mGWAS) detected genetic variants influencing diverse metabolic targets in developing and mature seeds. We further interlinked genetic variants on chromosome 7 (6.06–6.43 Mb region) with complex epistatic genetic interactions impacting multi‐dimensional nutritional targets, including complex carbohydrate starch quality, the glycemic index, antioxidant catechin, and rice grain color. Through this nutrigenomics approach rare gene bank accessions possessing genetic variants in bHLH and IPT5 genes were identified through haplotype enrichment. These variants were associated with a low glycemic index, higher catechin levels, elevated total flavonoid contents, and heightened antioxidant activity in the whole grain with elevated anti‐cancer properties being confirmed in cancer cell lines. This multi‐disciplinary nutrigenomics approach thus allowed us to discover the genetic basis of human health‐conferring diversity in the metabolome of brown rice. |
| format | Journal Article |
| id | CGSpace164316 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace1643162025-12-08T09:54:28Z The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition Brotman, Yariv Llorente-Wiegand, Cindy Oyong, Glenn Badoni, Saurabh Misra, Gopal Anacleto, Roslen Parween, Sabiha Pasion, Erstelle Tiozon, Rhowell N. Anonuevo, Joanne J. deGuzman, Maria K. Alseekh, Saleh Mbanjo, Edwige G. N. Boyd, Lesley A. Fernie, Alisdair R. Sreenivasulu, Nese Brown rice (Oryza sativa) possesses various nutritionally dense bioactive phytochemicals exhibiting a wide range of antioxidant, anti‐cancer, and anti‐diabetic properties known to promote various human health benefits. However, despite the wide claims made about the importance of brown rice for human nutrition the underlying metabolic diversity has not been systematically explored. Non‐targeted metabolite profiling of developing and mature seeds of a diverse genetic panel of 320 rice cultivars allowed quantification of 117 metabolites. The metabolite genome‐wide association study (mGWAS) detected genetic variants influencing diverse metabolic targets in developing and mature seeds. We further interlinked genetic variants on chromosome 7 (6.06–6.43 Mb region) with complex epistatic genetic interactions impacting multi‐dimensional nutritional targets, including complex carbohydrate starch quality, the glycemic index, antioxidant catechin, and rice grain color. Through this nutrigenomics approach rare gene bank accessions possessing genetic variants in bHLH and IPT5 genes were identified through haplotype enrichment. These variants were associated with a low glycemic index, higher catechin levels, elevated total flavonoid contents, and heightened antioxidant activity in the whole grain with elevated anti‐cancer properties being confirmed in cancer cell lines. This multi‐disciplinary nutrigenomics approach thus allowed us to discover the genetic basis of human health‐conferring diversity in the metabolome of brown rice. 2021-04 2024-12-19T12:53:44Z 2024-12-19T12:53:44Z Journal Article https://hdl.handle.net/10568/164316 en Wiley Brotman, Yariv; Llorente‐Wiegand, Cindy; Oyong, Glenn; Badoni, Saurabh; Misra, Gopal; Anacleto, Roslen; Parween, Sabiha; Pasion, Erstelle; Tiozon, Rhowell N.; Anonuevo, Joanne J.; deGuzman, Maria K.; Alseekh, Saleh; Mbanjo, Edwige G. N.; Boyd, Lesley A.; Fernie, Alisdair R. and Sreenivasulu, Nese. 2021. The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition. The Plant Journal, Volume 106 no. 2 p. 507-525 |
| spellingShingle | Brotman, Yariv Llorente-Wiegand, Cindy Oyong, Glenn Badoni, Saurabh Misra, Gopal Anacleto, Roslen Parween, Sabiha Pasion, Erstelle Tiozon, Rhowell N. Anonuevo, Joanne J. deGuzman, Maria K. Alseekh, Saleh Mbanjo, Edwige G. N. Boyd, Lesley A. Fernie, Alisdair R. Sreenivasulu, Nese The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition |
| title | The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition |
| title_full | The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition |
| title_fullStr | The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition |
| title_full_unstemmed | The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition |
| title_short | The genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition |
| title_sort | genetics underlying metabolic signatures in a brown rice diversity panel and their vital role in human nutrition |
| url | https://hdl.handle.net/10568/164316 |
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