Lysine biofortification of crops to promote sustained human health in the 21st century
Crop biofortification is pivotal in preventing malnutrition, with lysine considered the main limiting essential amino acid (EAA) required to maintain human health. Lysine deficiency is predominant in developing countries where cereal crops are the staple food, highlighting the need for efforts aimed...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
2022
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/164172 |
| _version_ | 1855535084966248448 |
|---|---|
| author | Yang, Qingqing Zhao, Dongsheng Zhang, Chuangquan Sreenivasulu, Nese Sun, Samuel Sai-Ming Liu, Qiaoquan |
| author_browse | Liu, Qiaoquan Sreenivasulu, Nese Sun, Samuel Sai-Ming Yang, Qingqing Zhang, Chuangquan Zhao, Dongsheng |
| author_facet | Yang, Qingqing Zhao, Dongsheng Zhang, Chuangquan Sreenivasulu, Nese Sun, Samuel Sai-Ming Liu, Qiaoquan |
| author_sort | Yang, Qingqing |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Crop biofortification is pivotal in preventing malnutrition, with lysine considered the main limiting essential amino acid (EAA) required to maintain human health. Lysine deficiency is predominant in developing countries where cereal crops are the staple food, highlighting the need for efforts aimed at enriching the staple diet through lysine biofortification. Successful modification of aspartate kinase (AK) and dihydrodipicolinate synthase (DHDPS) feedback inhibition has been used to enrich lysine in transgenic rice plants without yield penalty, while increases in the lysine content of quality protein maize have been achieved via marker-assisted selection. Here, we reviewed the lysine metabolic pathway and proposed the use of metabolic engineering targets as the preferred option for fortification of lysine in crops. Use of gene editing technologies to translate the findings and engineer lysine catabolism is thus a pioneering step forward. |
| format | Journal Article |
| id | CGSpace164172 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace1641722024-12-22T05:44:59Z Lysine biofortification of crops to promote sustained human health in the 21st century Yang, Qingqing Zhao, Dongsheng Zhang, Chuangquan Sreenivasulu, Nese Sun, Samuel Sai-Ming Liu, Qiaoquan physiology plant science Crop biofortification is pivotal in preventing malnutrition, with lysine considered the main limiting essential amino acid (EAA) required to maintain human health. Lysine deficiency is predominant in developing countries where cereal crops are the staple food, highlighting the need for efforts aimed at enriching the staple diet through lysine biofortification. Successful modification of aspartate kinase (AK) and dihydrodipicolinate synthase (DHDPS) feedback inhibition has been used to enrich lysine in transgenic rice plants without yield penalty, while increases in the lysine content of quality protein maize have been achieved via marker-assisted selection. Here, we reviewed the lysine metabolic pathway and proposed the use of metabolic engineering targets as the preferred option for fortification of lysine in crops. Use of gene editing technologies to translate the findings and engineer lysine catabolism is thus a pioneering step forward. 2022-03-02 2024-12-19T12:53:32Z 2024-12-19T12:53:32Z Journal Article https://hdl.handle.net/10568/164172 en Oxford University Press Yang, Qingqing; Zhao, Dongsheng; Zhang, Chuangquan; Sreenivasulu, Nese; Sun, Samuel Sai-Ming and Liu, Qiaoquan. 2022. Lysine biofortification of crops to promote sustained human health in the 21st century. Journal of Experimental Botany, erab482. |
| spellingShingle | physiology plant science Yang, Qingqing Zhao, Dongsheng Zhang, Chuangquan Sreenivasulu, Nese Sun, Samuel Sai-Ming Liu, Qiaoquan Lysine biofortification of crops to promote sustained human health in the 21st century |
| title | Lysine biofortification of crops to promote sustained human health in the 21st century |
| title_full | Lysine biofortification of crops to promote sustained human health in the 21st century |
| title_fullStr | Lysine biofortification of crops to promote sustained human health in the 21st century |
| title_full_unstemmed | Lysine biofortification of crops to promote sustained human health in the 21st century |
| title_short | Lysine biofortification of crops to promote sustained human health in the 21st century |
| title_sort | lysine biofortification of crops to promote sustained human health in the 21st century |
| topic | physiology plant science |
| url | https://hdl.handle.net/10568/164172 |
| work_keys_str_mv | AT yangqingqing lysinebiofortificationofcropstopromotesustainedhumanhealthinthe21stcentury AT zhaodongsheng lysinebiofortificationofcropstopromotesustainedhumanhealthinthe21stcentury AT zhangchuangquan lysinebiofortificationofcropstopromotesustainedhumanhealthinthe21stcentury AT sreenivasulunese lysinebiofortificationofcropstopromotesustainedhumanhealthinthe21stcentury AT sunsamuelsaiming lysinebiofortificationofcropstopromotesustainedhumanhealthinthe21stcentury AT liuqiaoquan lysinebiofortificationofcropstopromotesustainedhumanhealthinthe21stcentury |