Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy
MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two main categories of noncoding RNAs (ncRNAs) that can influence essential biological functions in various ways, as well as their expression and function are tightly regulated in physiological homeostasis. Additionally, the dysregulation of t...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Wiley
2022
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| Online Access: | https://hdl.handle.net/10568/164145 |
| _version_ | 1855516559677587456 |
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| author | Ruiz-Manriquez, Luis M. Estrada-Meza, Carolina Benavides-Aguilar, Javier A. Ledesma-Pacheco, S. Janin Torres-Copado, Andrea Serrano-Cano, Francisco I. Bandyopadhyay, Anindya Pathak, Surajit Chakraborty, Samik Srivastava, Aashish Sharma, Ashutosh Paul, Sujay |
| author_browse | Bandyopadhyay, Anindya Benavides-Aguilar, Javier A. Chakraborty, Samik Estrada-Meza, Carolina Ledesma-Pacheco, S. Janin Pathak, Surajit Paul, Sujay Ruiz-Manriquez, Luis M. Serrano-Cano, Francisco I. Sharma, Ashutosh Srivastava, Aashish Torres-Copado, Andrea |
| author_facet | Ruiz-Manriquez, Luis M. Estrada-Meza, Carolina Benavides-Aguilar, Javier A. Ledesma-Pacheco, S. Janin Torres-Copado, Andrea Serrano-Cano, Francisco I. Bandyopadhyay, Anindya Pathak, Surajit Chakraborty, Samik Srivastava, Aashish Sharma, Ashutosh Paul, Sujay |
| author_sort | Ruiz-Manriquez, Luis M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two main categories of noncoding RNAs (ncRNAs) that can influence essential biological functions in various ways, as well as their expression and function are tightly regulated in physiological homeostasis. Additionally, the dysregulation of these ncRNAs seems to be crucial to the pathogenesis of human diseases. The latest findings indicate that ncRNAs execute vital roles in cancer initiation and progression, and the cancer phenotype can be reversed by modulating their expression. Available scientific discoveries suggest that phytochemicals such as polyphenols, alkaloids, terpenoids, and organosulfur compounds can significantly modulate multiple cancer‐associated miRNAs and lncRNAs, thereby inhibiting cancer initiation and development. However, despite promising outcomes of experimental research, only a few clinical trials are currently being conducted to evaluate the therapeutic effectiveness of these compounds. Nevertheless, understanding phytochemical‐mediated ncRNA regulation in cancer and the underlying molecular mechanisms on tumor pathophysiology can aid in the development of novel therapeutic strategies to combat this deadly disease. |
| format | Journal Article |
| id | CGSpace164145 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace1641452025-05-14T10:23:53Z Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy Ruiz-Manriquez, Luis M. Estrada-Meza, Carolina Benavides-Aguilar, Javier A. Ledesma-Pacheco, S. Janin Torres-Copado, Andrea Serrano-Cano, Francisco I. Bandyopadhyay, Anindya Pathak, Surajit Chakraborty, Samik Srivastava, Aashish Sharma, Ashutosh Paul, Sujay pharmacology MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two main categories of noncoding RNAs (ncRNAs) that can influence essential biological functions in various ways, as well as their expression and function are tightly regulated in physiological homeostasis. Additionally, the dysregulation of these ncRNAs seems to be crucial to the pathogenesis of human diseases. The latest findings indicate that ncRNAs execute vital roles in cancer initiation and progression, and the cancer phenotype can be reversed by modulating their expression. Available scientific discoveries suggest that phytochemicals such as polyphenols, alkaloids, terpenoids, and organosulfur compounds can significantly modulate multiple cancer‐associated miRNAs and lncRNAs, thereby inhibiting cancer initiation and development. However, despite promising outcomes of experimental research, only a few clinical trials are currently being conducted to evaluate the therapeutic effectiveness of these compounds. Nevertheless, understanding phytochemical‐mediated ncRNA regulation in cancer and the underlying molecular mechanisms on tumor pathophysiology can aid in the development of novel therapeutic strategies to combat this deadly disease. 2022-02 2024-12-19T12:53:30Z 2024-12-19T12:53:30Z Journal Article https://hdl.handle.net/10568/164145 en Wiley Ruiz‐Manriquez, Luis M.; Estrada‐Meza, Carolina; Benavides‐Aguilar, Javier A.; Ledesma‐Pacheco, S. Janin; Torres‐Copado, Andrea; Serrano‐Cano, Francisco I.; Bandyopadhyay, Anindya; Pathak, Surajit; Chakraborty, Samik; Srivastava, Aashish; Sharma, Ashutosh and Paul, Sujay. 2021. Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy. Phytotherapy Research, Volume 36 no. 2 p. 705-729 |
| spellingShingle | pharmacology Ruiz-Manriquez, Luis M. Estrada-Meza, Carolina Benavides-Aguilar, Javier A. Ledesma-Pacheco, S. Janin Torres-Copado, Andrea Serrano-Cano, Francisco I. Bandyopadhyay, Anindya Pathak, Surajit Chakraborty, Samik Srivastava, Aashish Sharma, Ashutosh Paul, Sujay Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy |
| title | Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy |
| title_full | Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy |
| title_fullStr | Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy |
| title_full_unstemmed | Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy |
| title_short | Phytochemicals mediated modulation of micrornas and long non-coding rnas in cancer prevention and therapy |
| title_sort | phytochemicals mediated modulation of micrornas and long non coding rnas in cancer prevention and therapy |
| topic | pharmacology |
| url | https://hdl.handle.net/10568/164145 |
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