The emerging role of microRNAs in bone diseases and their therapeutic potential
MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory mo...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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MDPI
2021
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| Online Access: | https://hdl.handle.net/10568/164142 |
| _version_ | 1855537043881328640 |
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| author | Bravo Vázquez, Luis Alberto Moreno Becerril, Mariana Yunuen Mora Hernández, Erick Octavio León Carmona, Gabriela García de Aguirre Padilla, María Emilia Chakraborty, Samik Bandyopadhyay, Anindya Paul, Sujay |
| author_browse | Aguirre Padilla, María Emilia Bandyopadhyay, Anindya Bravo Vázquez, Luis Alberto Chakraborty, Samik León Carmona, Gabriela García de Mora Hernández, Erick Octavio Moreno Becerril, Mariana Yunuen Paul, Sujay |
| author_facet | Bravo Vázquez, Luis Alberto Moreno Becerril, Mariana Yunuen Mora Hernández, Erick Octavio León Carmona, Gabriela García de Aguirre Padilla, María Emilia Chakraborty, Samik Bandyopadhyay, Anindya Paul, Sujay |
| author_sort | Bravo Vázquez, Luis Alberto |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory molecules are implicated in several biological processes, their altered expression affects the preservation of cellular homeostasis and leads to the development of a wide range of pathologies. Over the last few years, relevant investigations have elucidated that miRNAs participate in different stages of bone growth and development. Moreover, the abnormal expression of these RNA molecules in bone cells and tissues has been significantly associated with the progression of numerous bone diseases, including osteoporosis, osteosarcoma, osteonecrosis and bone metastasis, among others. In fact, miRNAs regulate multiple pathological mechanisms, including altering either osteogenic or osteoblast differentiation, metastasis, osteosarcoma cell proliferation, and bone loss. Therefore, in this present review, aiming to impulse the research arena of the biological implications of miRNA transcriptome in bone diseases and to explore their potentiality as a theragnostic target, we summarize the recent findings associated with the clinical significance of miRNAs in these ailments. |
| format | Journal Article |
| id | CGSpace164142 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | CGSpace1641422024-12-22T05:44:59Z The emerging role of microRNAs in bone diseases and their therapeutic potential Bravo Vázquez, Luis Alberto Moreno Becerril, Mariana Yunuen Mora Hernández, Erick Octavio León Carmona, Gabriela García de Aguirre Padilla, María Emilia Chakraborty, Samik Bandyopadhyay, Anindya Paul, Sujay chemistry (miscellaneous) analytical chemistry organic chemistry physical and theoretical chemistry molecular medicine drug discovery pharmaceutical science MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory molecules are implicated in several biological processes, their altered expression affects the preservation of cellular homeostasis and leads to the development of a wide range of pathologies. Over the last few years, relevant investigations have elucidated that miRNAs participate in different stages of bone growth and development. Moreover, the abnormal expression of these RNA molecules in bone cells and tissues has been significantly associated with the progression of numerous bone diseases, including osteoporosis, osteosarcoma, osteonecrosis and bone metastasis, among others. In fact, miRNAs regulate multiple pathological mechanisms, including altering either osteogenic or osteoblast differentiation, metastasis, osteosarcoma cell proliferation, and bone loss. Therefore, in this present review, aiming to impulse the research arena of the biological implications of miRNA transcriptome in bone diseases and to explore their potentiality as a theragnostic target, we summarize the recent findings associated with the clinical significance of miRNAs in these ailments. 2021-12-30 2024-12-19T12:53:30Z 2024-12-19T12:53:30Z Journal Article https://hdl.handle.net/10568/164142 en Open Access MDPI Bravo Vázquez, Luis Alberto; Moreno Becerril, Mariana Yunuen; Mora Hernández, Erick Octavio; León Carmona, Gabriela García de; Aguirre Padilla, María Emilia; Chakraborty, Samik; Bandyopadhyay, Anindya and Paul, Sujay. 2021. The emerging role of microRNAs in bone diseases and their therapeutic potential. Molecules, Volume 27 no. 1 p. 211 |
| spellingShingle | chemistry (miscellaneous) analytical chemistry organic chemistry physical and theoretical chemistry molecular medicine drug discovery pharmaceutical science Bravo Vázquez, Luis Alberto Moreno Becerril, Mariana Yunuen Mora Hernández, Erick Octavio León Carmona, Gabriela García de Aguirre Padilla, María Emilia Chakraborty, Samik Bandyopadhyay, Anindya Paul, Sujay The emerging role of microRNAs in bone diseases and their therapeutic potential |
| title | The emerging role of microRNAs in bone diseases and their therapeutic potential |
| title_full | The emerging role of microRNAs in bone diseases and their therapeutic potential |
| title_fullStr | The emerging role of microRNAs in bone diseases and their therapeutic potential |
| title_full_unstemmed | The emerging role of microRNAs in bone diseases and their therapeutic potential |
| title_short | The emerging role of microRNAs in bone diseases and their therapeutic potential |
| title_sort | emerging role of micrornas in bone diseases and their therapeutic potential |
| topic | chemistry (miscellaneous) analytical chemistry organic chemistry physical and theoretical chemistry molecular medicine drug discovery pharmaceutical science |
| url | https://hdl.handle.net/10568/164142 |
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