MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. The molecular pathogenesis of HCC varies due to the different etiologies and genotoxic insults. The development of HCC is characterized by complex interactions between several etiological factors that result in genetic a...
| Autores principales: | , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Frontiers Media
2022
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| Acceso en línea: | https://hdl.handle.net/10568/164033 |
| _version_ | 1855535444812365824 |
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| author | Ruiz-Manriquez, Luis M. Carrasco-Morales, Oscar Sanchez Z, E. Adrian Osorio-Pérez, Sofía Madeline Estrada-Meza, Carolina Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay |
| author_browse | Bandyopadhyay, Anindya Banerjee, Antara Carrasco-Morales, Oscar Duttaroy, Asim K. Estrada-Meza, Carolina Osorio-Pérez, Sofía Madeline Pathak, Surajit Paul, Sujay Ruiz-Manriquez, Luis M. Sanchez Z, E. Adrian |
| author_facet | Ruiz-Manriquez, Luis M. Carrasco-Morales, Oscar Sanchez Z, E. Adrian Osorio-Pérez, Sofía Madeline Estrada-Meza, Carolina Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay |
| author_sort | Ruiz-Manriquez, Luis M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. The molecular pathogenesis of HCC varies due to the different etiologies and genotoxic insults. The development of HCC is characterized by complex interactions between several etiological factors that result in genetic and epigenetic changes in proto-onco and/or tumor suppressor genes. MicroRNAs (miRNAs) are short non-coding RNAs that also can act as oncomiRs or tumor suppressors regulating the expression of cancer-associated genes post-transcriptionally. Studies revealed that several microRNAs are directly or indirectly involved in cellular signaling, and dysregulation of those miRNAs in the body fluids or tissues potentially affects key signaling pathways resulting in carcinogenesis. Therefore, in this mini-review, we discussed recent progress in microRNA-mediated regulation of crucial signaling networks during HCC development, concentrating on the most relevant ones such as PI3K/Akt/mTOR, Hippo-YAP/TAZ, and Wnt/β-catenin, which might open new avenues in HCC management. |
| format | Journal Article |
| id | CGSpace164033 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | CGSpace1640332025-12-08T10:29:22Z MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight Ruiz-Manriquez, Luis M. Carrasco-Morales, Oscar Sanchez Z, E. Adrian Osorio-Pérez, Sofía Madeline Estrada-Meza, Carolina Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay genetics medical sciences Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. The molecular pathogenesis of HCC varies due to the different etiologies and genotoxic insults. The development of HCC is characterized by complex interactions between several etiological factors that result in genetic and epigenetic changes in proto-onco and/or tumor suppressor genes. MicroRNAs (miRNAs) are short non-coding RNAs that also can act as oncomiRs or tumor suppressors regulating the expression of cancer-associated genes post-transcriptionally. Studies revealed that several microRNAs are directly or indirectly involved in cellular signaling, and dysregulation of those miRNAs in the body fluids or tissues potentially affects key signaling pathways resulting in carcinogenesis. Therefore, in this mini-review, we discussed recent progress in microRNA-mediated regulation of crucial signaling networks during HCC development, concentrating on the most relevant ones such as PI3K/Akt/mTOR, Hippo-YAP/TAZ, and Wnt/β-catenin, which might open new avenues in HCC management. 2022-09-02 2024-12-19T12:53:21Z 2024-12-19T12:53:21Z Journal Article https://hdl.handle.net/10568/164033 en Open Access Frontiers Media Ruiz-Manriquez, Luis M.; Carrasco-Morales, Oscar; Sanchez Z, E. Adrian; Osorio-Perez, Sofía Madeline; Estrada-Meza, Carolina; Pathak, Surajit; Banerjee, Antara; Bandyopadhyay, Anindya; Duttaroy, Asim K. and Paul, Sujay. 2022. MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight. Front. Genet., Volume 13 |
| spellingShingle | genetics medical sciences Ruiz-Manriquez, Luis M. Carrasco-Morales, Oscar Sanchez Z, E. Adrian Osorio-Pérez, Sofía Madeline Estrada-Meza, Carolina Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight |
| title | MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight |
| title_full | MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight |
| title_fullStr | MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight |
| title_full_unstemmed | MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight |
| title_short | MicroRNA-mediated regulation of key signaling pathways in hepatocellular carcinoma: A mechanistic insight |
| title_sort | microrna mediated regulation of key signaling pathways in hepatocellular carcinoma a mechanistic insight |
| topic | genetics medical sciences |
| url | https://hdl.handle.net/10568/164033 |
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