MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through different epigenetic regulatory mechanisms of gene expression. As a matter of fact, the altered expression of these types of...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2023
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/164005 |
| _version_ | 1855529218116419584 |
|---|---|
| author | Bravo-Vázquez, Luis Alberto Frías-Reid, Natalia Ramos-Delgado, Ana Gabriela Osorio-Pérez, Sofía Madeline Zlotnik-Chávez, Hania Ruth Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay |
| author_browse | Bandyopadhyay, Anindya Banerjee, Antara Bravo-Vázquez, Luis Alberto Duttaroy, Asim K. Frías-Reid, Natalia Osorio-Pérez, Sofía Madeline Pathak, Surajit Paul, Sujay Ramos-Delgado, Ana Gabriela Zlotnik-Chávez, Hania Ruth |
| author_facet | Bravo-Vázquez, Luis Alberto Frías-Reid, Natalia Ramos-Delgado, Ana Gabriela Osorio-Pérez, Sofía Madeline Zlotnik-Chávez, Hania Ruth Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay |
| author_sort | Bravo-Vázquez, Luis Alberto |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through different epigenetic regulatory mechanisms of gene expression. As a matter of fact, the altered expression of these types of RNAs leads to the development and progression of a varied range of multifactorial human diseases. Several recent reports elucidated that miRNA and lncRNAs have been implicated in pancreatic cancer (PC). For instance, dysregulation of such ncRNAs has been found to be associated with chemoresistance, apoptosis, autophagy, cell differentiation, tumor suppression, tumor growth, cancer cell proliferation, migration, and invasion in PC. Moreover, several aberrantly expressed miRNAs and lncRNAs have the potential to be used as biomarkers for accurate PC diagnosis. Additionally, miRNAs and lncRNAs are considered as promising clinical targets for PC. Therefore, in this review, we discuss recent experimental evidence regarding the clinical implications of miRNAs and lncRNAs in the pathophysiology of PC, their future potential, as well as the challenges that have arisen in this field of study in order to drive forward the design of ncRNA-based diagnostics and therapeutics for PC. |
| format | Journal Article |
| id | CGSpace164005 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1640052024-12-19T14:12:52Z MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications Bravo-Vázquez, Luis Alberto Frías-Reid, Natalia Ramos-Delgado, Ana Gabriela Osorio-Pérez, Sofía Madeline Zlotnik-Chávez, Hania Ruth Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay cancer research oncology MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two relevant classes of non-coding RNAs (ncRNAs) that play a pivotal role in a number of molecular processes through different epigenetic regulatory mechanisms of gene expression. As a matter of fact, the altered expression of these types of RNAs leads to the development and progression of a varied range of multifactorial human diseases. Several recent reports elucidated that miRNA and lncRNAs have been implicated in pancreatic cancer (PC). For instance, dysregulation of such ncRNAs has been found to be associated with chemoresistance, apoptosis, autophagy, cell differentiation, tumor suppression, tumor growth, cancer cell proliferation, migration, and invasion in PC. Moreover, several aberrantly expressed miRNAs and lncRNAs have the potential to be used as biomarkers for accurate PC diagnosis. Additionally, miRNAs and lncRNAs are considered as promising clinical targets for PC. Therefore, in this review, we discuss recent experimental evidence regarding the clinical implications of miRNAs and lncRNAs in the pathophysiology of PC, their future potential, as well as the challenges that have arisen in this field of study in order to drive forward the design of ncRNA-based diagnostics and therapeutics for PC. 2023-01 2024-12-19T12:53:19Z 2024-12-19T12:53:19Z Journal Article https://hdl.handle.net/10568/164005 en Open Access Elsevier Bravo-Vázquez, Luis Alberto; Frías-Reid, Natalia; Ramos-Delgado, Ana Gabriela; Osorio-Pérez, Sofía Madeline; Zlotnik-Chávez, Hania Ruth; Pathak, Surajit; Banerjee, Antara; Bandyopadhyay, Anindya; Duttaroy, Asim K. and Paul, Sujay. 2023. MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications. Translational Oncology, Volume 27 p. 101579 |
| spellingShingle | cancer research oncology Bravo-Vázquez, Luis Alberto Frías-Reid, Natalia Ramos-Delgado, Ana Gabriela Osorio-Pérez, Sofía Madeline Zlotnik-Chávez, Hania Ruth Pathak, Surajit Banerjee, Antara Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_full | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_fullStr | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_full_unstemmed | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_short | MicroRNAs and long non-coding RNAs in pancreatic cancer: From epigenetics to potential clinical applications |
| title_sort | micrornas and long non coding rnas in pancreatic cancer from epigenetics to potential clinical applications |
| topic | cancer research oncology |
| url | https://hdl.handle.net/10568/164005 |
| work_keys_str_mv | AT bravovazquezluisalberto micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT friasreidnatalia micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT ramosdelgadoanagabriela micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT osorioperezsofiamadeline micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT zlotnikchavezhaniaruth micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT pathaksurajit micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT banerjeeantara micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT bandyopadhyayanindya micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT duttaroyasimk micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications AT paulsujay micrornasandlongnoncodingrnasinpancreaticcancerfromepigeneticstopotentialclinicalapplications |