Current advances of plant-based vaccines for neurodegenerative diseases
Neurodegenerative diseases (NDDs) are characterized by the progressive degeneration and/or loss of neurons belonging to the central nervous system, and represent one of the major global health issues. Therefore, a number of immunotherapeutic approaches targeting the non-functional or toxic proteins...
| Autores principales: | , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
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MDPI
2023
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| Acceso en línea: | https://hdl.handle.net/10568/163981 |
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| author | Bravo-Vázquez, Luis Alberto Mora-Hernández, Erick Octavio Rodríguez, Alma L. Sahare, Padmavati Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay |
| author_browse | Bandyopadhyay, Anindya Bravo-Vázquez, Luis Alberto Duttaroy, Asim K. Mora-Hernández, Erick Octavio Paul, Sujay Rodríguez, Alma L. Sahare, Padmavati |
| author_facet | Bravo-Vázquez, Luis Alberto Mora-Hernández, Erick Octavio Rodríguez, Alma L. Sahare, Padmavati Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay |
| author_sort | Bravo-Vázquez, Luis Alberto |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Neurodegenerative diseases (NDDs) are characterized by the progressive degeneration and/or loss of neurons belonging to the central nervous system, and represent one of the major global health issues. Therefore, a number of immunotherapeutic approaches targeting the non-functional or toxic proteins that induce neurodegeneration in NDDs have been designed in the last decades. In this context, due to unprecedented advances in genetic engineering techniques and molecular farming technology, pioneering plant-based immunogenic antigen expression systems have been developed aiming to offer reliable alternatives to deal with important NDDs, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Diverse reports have evidenced that plant-made vaccines trigger significant immune responses in model animals, supported by the production of antibodies against the aberrant proteins expressed in the aforementioned NDDs. Moreover, these immunogenic tools have various advantages that make them a viable alternative for preventing and treating NDDs, such as high scalability, no risk of contamination with human pathogens, cold chain free production, and lower production costs. Hence, this article presents an overview of the current progress on plant-manufactured vaccines for NDDs and discusses its future prospects. |
| format | Journal Article |
| id | CGSpace163981 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | CGSpace1639812025-12-08T10:29:22Z Current advances of plant-based vaccines for neurodegenerative diseases Bravo-Vázquez, Luis Alberto Mora-Hernández, Erick Octavio Rodríguez, Alma L. Sahare, Padmavati Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay pharmaceutical science Neurodegenerative diseases (NDDs) are characterized by the progressive degeneration and/or loss of neurons belonging to the central nervous system, and represent one of the major global health issues. Therefore, a number of immunotherapeutic approaches targeting the non-functional or toxic proteins that induce neurodegeneration in NDDs have been designed in the last decades. In this context, due to unprecedented advances in genetic engineering techniques and molecular farming technology, pioneering plant-based immunogenic antigen expression systems have been developed aiming to offer reliable alternatives to deal with important NDDs, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Diverse reports have evidenced that plant-made vaccines trigger significant immune responses in model animals, supported by the production of antibodies against the aberrant proteins expressed in the aforementioned NDDs. Moreover, these immunogenic tools have various advantages that make them a viable alternative for preventing and treating NDDs, such as high scalability, no risk of contamination with human pathogens, cold chain free production, and lower production costs. Hence, this article presents an overview of the current progress on plant-manufactured vaccines for NDDs and discusses its future prospects. 2023-02-20 2024-12-19T12:53:18Z 2024-12-19T12:53:18Z Journal Article https://hdl.handle.net/10568/163981 en Open Access MDPI Bravo-Vázquez, Luis Alberto; Mora-Hernández, Erick Octavio; Rodríguez, Alma L.; Sahare, Padmavati; Bandyopadhyay, Anindya; Duttaroy, Asim K. and Paul, Sujay. 2023. Current advances of plant-based vaccines for neurodegenerative diseases. Pharmaceutics, Volume 15 no. 2 p. 711 |
| spellingShingle | pharmaceutical science Bravo-Vázquez, Luis Alberto Mora-Hernández, Erick Octavio Rodríguez, Alma L. Sahare, Padmavati Bandyopadhyay, Anindya Duttaroy, Asim K. Paul, Sujay Current advances of plant-based vaccines for neurodegenerative diseases |
| title | Current advances of plant-based vaccines for neurodegenerative diseases |
| title_full | Current advances of plant-based vaccines for neurodegenerative diseases |
| title_fullStr | Current advances of plant-based vaccines for neurodegenerative diseases |
| title_full_unstemmed | Current advances of plant-based vaccines for neurodegenerative diseases |
| title_short | Current advances of plant-based vaccines for neurodegenerative diseases |
| title_sort | current advances of plant based vaccines for neurodegenerative diseases |
| topic | pharmaceutical science |
| url | https://hdl.handle.net/10568/163981 |
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