Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin
This study presents a comprehensive transcriptome analysis of canine intestinal epithelial cells following treatment with sulforaphane (SFN), a naturally occurring compound found in cruciferous vegetables with established anti-inflammatory and antioxidant properties. Through high-throughput sequenci...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Frontiers Media
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/163012 |
| _version_ | 1855519700025344000 |
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| author | Kaiqi Li Jin Yan Shiqi Wang Chuyang Zhu Qi Zhu Sichen Lu Ping Hu Dessie, Tadelle In Ho Kim Ahmed, A.A. Hao-Yu Liu Ennab, W. Demin Cai |
| author_browse | Ahmed, A.A. Chuyang Zhu Demin Cai Dessie, Tadelle Ennab, W. Hao-Yu Liu In Ho Kim Jin Yan Kaiqi Li Ping Hu Qi Zhu Shiqi Wang Sichen Lu |
| author_facet | Kaiqi Li Jin Yan Shiqi Wang Chuyang Zhu Qi Zhu Sichen Lu Ping Hu Dessie, Tadelle In Ho Kim Ahmed, A.A. Hao-Yu Liu Ennab, W. Demin Cai |
| author_sort | Kaiqi Li |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | This study presents a comprehensive transcriptome analysis of canine intestinal epithelial cells following treatment with sulforaphane (SFN), a naturally occurring compound found in cruciferous vegetables with established anti-inflammatory and antioxidant properties. Through high-throughput sequencing, we identified 29,993 genes, among which 1,612 were differentially expressed, with 792 up-regulated and 820 down-regulated in response to SFN treatment. Our analysis revealed significant enrichment of genes in pathways associated with the inflammatory response, lipid metabolism, oxidative stress response, and T-cell mediated immunity, suggesting SFN’s potential in modulating these biological processes. Notably, the PPARγ gene, which plays a crucial role in the body’s oxidative stress and inflammatory response, was highly up-regulated, indicating its possible centrality in SFN’s effects. Gene–gene interaction analysis further supported SFN’s role in alleviating inflammation through PPARγ, with key genes in oxidat |
| format | Journal Article |
| id | CGSpace163012 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | CGSpace1630122025-12-08T10:29:22Z Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin Kaiqi Li Jin Yan Shiqi Wang Chuyang Zhu Qi Zhu Sichen Lu Ping Hu Dessie, Tadelle In Ho Kim Ahmed, A.A. Hao-Yu Liu Ennab, W. Demin Cai animal health antioxidants dogs transcriptome This study presents a comprehensive transcriptome analysis of canine intestinal epithelial cells following treatment with sulforaphane (SFN), a naturally occurring compound found in cruciferous vegetables with established anti-inflammatory and antioxidant properties. Through high-throughput sequencing, we identified 29,993 genes, among which 1,612 were differentially expressed, with 792 up-regulated and 820 down-regulated in response to SFN treatment. Our analysis revealed significant enrichment of genes in pathways associated with the inflammatory response, lipid metabolism, oxidative stress response, and T-cell mediated immunity, suggesting SFN’s potential in modulating these biological processes. Notably, the PPARγ gene, which plays a crucial role in the body’s oxidative stress and inflammatory response, was highly up-regulated, indicating its possible centrality in SFN’s effects. Gene–gene interaction analysis further supported SFN’s role in alleviating inflammation through PPARγ, with key genes in oxidat 2024-10-02 2024-12-04T05:47:20Z 2024-12-04T05:47:20Z Journal Article https://hdl.handle.net/10568/163012 en Open Access Frontiers Media Li, K., Yan, J., Wang, S., Zhu, C., Zhu, Q., Lu, S., Hu, P., Dessie, T., Kim, I.H., Ahmed, A.A., Liu, H.Y., Ennab, W. and Cai, D. 2024. Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin. Frontiers in Veterinary Science 11 |
| spellingShingle | animal health antioxidants dogs transcriptome Kaiqi Li Jin Yan Shiqi Wang Chuyang Zhu Qi Zhu Sichen Lu Ping Hu Dessie, Tadelle In Ho Kim Ahmed, A.A. Hao-Yu Liu Ennab, W. Demin Cai Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin |
| title | Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin |
| title_full | Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin |
| title_fullStr | Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin |
| title_full_unstemmed | Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin |
| title_short | Transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane: a natural product of cruciferous origin |
| title_sort | transcriptome analysis provides new insights into the response of canine intestinal epithelial cells treated by sulforaphane a natural product of cruciferous origin |
| topic | animal health antioxidants dogs transcriptome |
| url | https://hdl.handle.net/10568/163012 |
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