Genetic Basis of Trypanotolerance in Cattle and Mice
Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the severe anaemia and production loss th...
| Main Authors: | , |
|---|---|
| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
1998
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/1566 |
| _version_ | 1855534006784753664 |
|---|---|
| author | Kemp, Stephen J. Teale, A.J. |
| author_browse | Kemp, Stephen J. Teale, A.J. |
| author_facet | Kemp, Stephen J. Teale, A.J. |
| author_sort | Kemp, Stephen J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the severe anaemia and production loss that are characteristic of infection in susceptible hosts. As discussed here by Stephen Kemp and Alan Teale, the genetic control of this phenomenon might finally be yielding to gene mapping studies. Genetic regions determining susceptibility to trypanosomiasis in mice have been identified and parallel studies are well advanced in cattle. There is growing evidence that only modest numbers of genes are involved in determining the difference between a susceptible and a resistant animal. These observations raise a new series of important questions concerning the possible exploitation of major trypanotolerance genes and the way that they might function in different genetic and physical environments. |
| format | Journal Article |
| id | CGSpace1566 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 1998 |
| publishDateRange | 1998 |
| publishDateSort | 1998 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace15662024-04-25T06:01:28Z Genetic Basis of Trypanotolerance in Cattle and Mice Kemp, Stephen J. Teale, A.J. disease control trypanosomiasis cattle mice trypanotolerance gene mapping genes genetic control african trypanosomiasis trypanosoma vivax trypanosoma congolense trypanosoma brucei livestock disease resistance laboratory animals Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the severe anaemia and production loss that are characteristic of infection in susceptible hosts. As discussed here by Stephen Kemp and Alan Teale, the genetic control of this phenomenon might finally be yielding to gene mapping studies. Genetic regions determining susceptibility to trypanosomiasis in mice have been identified and parallel studies are well advanced in cattle. There is growing evidence that only modest numbers of genes are involved in determining the difference between a susceptible and a resistant animal. These observations raise a new series of important questions concerning the possible exploitation of major trypanotolerance genes and the way that they might function in different genetic and physical environments. 1998-11 2010-05-18T21:01:46Z 2010-05-18T21:01:46Z Journal Article https://hdl.handle.net/10568/1566 en Limited Access Elsevier Kemp, S. J., & Teale, A. J. (1998). Genetic Basis of Trypanotolerance in Cattle and Mice. Parasitology Today, 14(11), 450–454. https://doi.org/10.1016/s0169-4758(98)01334-9 |
| spellingShingle | disease control trypanosomiasis cattle mice trypanotolerance gene mapping genes genetic control african trypanosomiasis trypanosoma vivax trypanosoma congolense trypanosoma brucei livestock disease resistance laboratory animals Kemp, Stephen J. Teale, A.J. Genetic Basis of Trypanotolerance in Cattle and Mice |
| title | Genetic Basis of Trypanotolerance in Cattle and Mice |
| title_full | Genetic Basis of Trypanotolerance in Cattle and Mice |
| title_fullStr | Genetic Basis of Trypanotolerance in Cattle and Mice |
| title_full_unstemmed | Genetic Basis of Trypanotolerance in Cattle and Mice |
| title_short | Genetic Basis of Trypanotolerance in Cattle and Mice |
| title_sort | genetic basis of trypanotolerance in cattle and mice |
| topic | disease control trypanosomiasis cattle mice trypanotolerance gene mapping genes genetic control african trypanosomiasis trypanosoma vivax trypanosoma congolense trypanosoma brucei livestock disease resistance laboratory animals |
| url | https://hdl.handle.net/10568/1566 |
| work_keys_str_mv | AT kempstephenj geneticbasisoftrypanotoleranceincattleandmice AT tealeaj geneticbasisoftrypanotoleranceincattleandmice |