Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice
Inbred strains of laboratory mice exhibit marked differences in survival time following infection with Trypanosoma congolense, the principal cause of trypanosomiasis in African livestock.The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred str...
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Wiley
2000
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/1565 |
| _version_ | 1855543305507438592 |
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| author | Clapcott, S.J. Teale, A.J. Kemp, Stephen J. |
| author_browse | Clapcott, S.J. Kemp, Stephen J. Teale, A.J. |
| author_facet | Clapcott, S.J. Teale, A.J. Kemp, Stephen J. |
| author_sort | Clapcott, S.J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Inbred strains of laboratory mice exhibit marked differences in survival time following infection with Trypanosoma congolense, the principal cause of trypanosomiasis in African livestock.The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred strains has been attributed to three quantitative trait loci (QTLs), Tir1, Tir2 and Tir3. In order to determine whether there was a parent-of-origin effect on this trait, four backcross populations derived from the C57BL/6 J and BALB/c parental strains were bred and inoculated with T. congolense. The two populations with F1 fathers and BALB/c mothers had a signi®cantly greater overall survival rate than the two populations with BALB/c fathers and F1 mothers. This pattern of inheritance suggested the involvement of imprinted genes. Genotyping with markers at the three QTLs controlling susceptibility revealed that the difference in survival time was consistent with genomic imprinting of the QTL of largest effect, Tir1. |
| format | Journal Article |
| id | CGSpace1565 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2000 |
| publishDateRange | 2000 |
| publishDateSort | 2000 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace15652024-05-01T08:20:09Z Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice Clapcott, S.J. Teale, A.J. Kemp, Stephen J. genetics trypanosomiasis Inbred strains of laboratory mice exhibit marked differences in survival time following infection with Trypanosoma congolense, the principal cause of trypanosomiasis in African livestock.The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred strains has been attributed to three quantitative trait loci (QTLs), Tir1, Tir2 and Tir3. In order to determine whether there was a parent-of-origin effect on this trait, four backcross populations derived from the C57BL/6 J and BALB/c parental strains were bred and inoculated with T. congolense. The two populations with F1 fathers and BALB/c mothers had a signi®cantly greater overall survival rate than the two populations with BALB/c fathers and F1 mothers. This pattern of inheritance suggested the involvement of imprinted genes. Genotyping with markers at the three QTLs controlling susceptibility revealed that the difference in survival time was consistent with genomic imprinting of the QTL of largest effect, Tir1. 2000-05 2010-05-18T21:00:29Z 2010-05-18T21:00:29Z Journal Article https://hdl.handle.net/10568/1565 en Open Access Wiley Clapcott, S.J.; Teale, A.J.; Kemp, S.J. 2000. Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice. Parasite Immunology 22:259-263. |
| spellingShingle | genetics trypanosomiasis Clapcott, S.J. Teale, A.J. Kemp, Stephen J. Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice |
| title | Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice |
| title_full | Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice |
| title_fullStr | Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice |
| title_full_unstemmed | Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice |
| title_short | Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice |
| title_sort | evidence for genomic imprinting of the major qtl controlling susceptibility to trypanosomiasis in mice |
| topic | genetics trypanosomiasis |
| url | https://hdl.handle.net/10568/1565 |
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