Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia
To determine the prevalence of vitamin A deficiency, infection and adequacy of vitamin A intakes among Zambian children, and the contribution of dietary vitamin A and infection to vitamin A status.A cross-sectional survey of vitamin A intakes by the 24 h recall method, vitamin A status by plasma ret...
| Autores principales: | , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Cambridge University Press
2012
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| Acceso en línea: | https://hdl.handle.net/10568/153077 |
| _version_ | 1855531881655697408 |
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| author | Hotz, Christine Chileshe, Justin Siamusantu, Ward Palaniappan, Uma Kafwembe, Emmanuel |
| author_browse | Chileshe, Justin Hotz, Christine Kafwembe, Emmanuel Palaniappan, Uma Siamusantu, Ward |
| author_facet | Hotz, Christine Chileshe, Justin Siamusantu, Ward Palaniappan, Uma Kafwembe, Emmanuel |
| author_sort | Hotz, Christine |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | To determine the prevalence of vitamin A deficiency, infection and adequacy of vitamin A intakes among Zambian children, and the contribution of dietary vitamin A and infection to vitamin A status.A cross-sectional survey of vitamin A intakes by the 24 h recall method, vitamin A status by plasma retinol and the modified relative dose-response test, and infection by acute-phase proteins.Rural communities in Central and Eastern Provinces of Zambia.Children 2–5 years of age.The prevalence of vitamin A deficiency was 56 % by plasma retinol, 48 % with infection-adjusted plasma retinol and 22 % by the modified relative dose-response test. The majority of children (61 %) had a current infection. Vitamin A intakes were relatively high (331 to 585 μg retinol activity equivalents/d in the harvest/early post-harvest and late post-harvest seasons, respectively) and the prevalence of inadequate intakes was <1 % when compared with the Estimated Average Requirement (210 and 275 μg retinol activity equivalents/d for children aged 1–3 and 4–8 years, respectively). Elevated α-1-acid glycoprotein was negatively associated with plasma retinol (P< 0·0 0 1) and vitamin A intake was positively associated with plasma retinol (P< 0·05), but only when estimated assuming a 26:1 retinol equivalence for provitamin A from green and yellow vegetables.Infection and vitamin A intakes were significant determinants of plasma retinol. We cannot conclude which indicator more accurately represents the true vitamin A status of the population. Reasons for the persistent high prevalence of vitamin A deficiency in the presence of adequate vitamin A intakes are unclear, but the high rates of infection may play a role. |
| format | Journal Article |
| id | CGSpace153077 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace1530772024-11-15T08:52:46Z Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia Hotz, Christine Chileshe, Justin Siamusantu, Ward Palaniappan, Uma Kafwembe, Emmanuel To determine the prevalence of vitamin A deficiency, infection and adequacy of vitamin A intakes among Zambian children, and the contribution of dietary vitamin A and infection to vitamin A status.A cross-sectional survey of vitamin A intakes by the 24 h recall method, vitamin A status by plasma retinol and the modified relative dose-response test, and infection by acute-phase proteins.Rural communities in Central and Eastern Provinces of Zambia.Children 2–5 years of age.The prevalence of vitamin A deficiency was 56 % by plasma retinol, 48 % with infection-adjusted plasma retinol and 22 % by the modified relative dose-response test. The majority of children (61 %) had a current infection. Vitamin A intakes were relatively high (331 to 585 μg retinol activity equivalents/d in the harvest/early post-harvest and late post-harvest seasons, respectively) and the prevalence of inadequate intakes was <1 % when compared with the Estimated Average Requirement (210 and 275 μg retinol activity equivalents/d for children aged 1–3 and 4–8 years, respectively). Elevated α-1-acid glycoprotein was negatively associated with plasma retinol (P< 0·0 0 1) and vitamin A intake was positively associated with plasma retinol (P< 0·05), but only when estimated assuming a 26:1 retinol equivalence for provitamin A from green and yellow vegetables.Infection and vitamin A intakes were significant determinants of plasma retinol. We cannot conclude which indicator more accurately represents the true vitamin A status of the population. Reasons for the persistent high prevalence of vitamin A deficiency in the presence of adequate vitamin A intakes are unclear, but the high rates of infection may play a role. 2012-09 2024-10-01T13:55:36Z 2024-10-01T13:55:36Z Journal Article https://hdl.handle.net/10568/153077 en Limited Access Cambridge University Press Hotz, Christine; Chileshe, Justin; Siamusantu, Ward; Palaniappan, Uma; Kafwembe, Emmanuel 2012. Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia. Public Health Nutrition 15(9): 1688-1696 |
| spellingShingle | Hotz, Christine Chileshe, Justin Siamusantu, Ward Palaniappan, Uma Kafwembe, Emmanuel Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia |
| title | Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia |
| title_full | Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia |
| title_fullStr | Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia |
| title_full_unstemmed | Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia |
| title_short | Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia |
| title_sort | vitamin a intake and infection are associated with plasma retinol among pre school children in rural zambia |
| url | https://hdl.handle.net/10568/153077 |
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