Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases
Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting su...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Frontiers Media
2024
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| Online Access: | https://hdl.handle.net/10568/151841 |
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| author | Li, K. Wang, S. Qu, W. Ahmed, A.A. Enneb, W. Obeidat, M.D. Liu, H.-Y. Dessie, Tadelle Kim, I.H. Adam, S.Y. Cai, D. |
| author_browse | Adam, S.Y. Ahmed, A.A. Cai, D. Dessie, Tadelle Enneb, W. Kim, I.H. Li, K. Liu, H.-Y. Obeidat, M.D. Qu, W. Wang, S. |
| author_facet | Li, K. Wang, S. Qu, W. Ahmed, A.A. Enneb, W. Obeidat, M.D. Liu, H.-Y. Dessie, Tadelle Kim, I.H. Adam, S.Y. Cai, D. |
| author_sort | Li, K. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting substantial health risks.
Methods: This review examines the pharmacological, toxicological, and microbiological impacts of natural products on mycotoxicosis, with a particular focus on the gut-x axis. The analysis synthesizes current understanding and explores the role of natural products rich in polysaccharides, polyphenols, flavonoids, and saponins.
Results: The review highlights that mycotoxins can disrupt intestinal integrity, alter inflammatory responses, damage the mucus layer, and disturb the bacterial balance. The toxins' effects are extensive, potentially harming the immune system, liver, kidneys, and skin, and are associated with serious conditions such as cancer, hormonal changes, genetic mutations, bleeding, birth defects, and neurological issues. Natural products have shown potential anticancer, anti-tumor, antioxidant, immunomodulatory, and antitoxic properties.
Discussion: The review underscores the emerging therapeutic strategy of targeting gut microbial modulation. It identifies knowledge gaps and suggests future research directions to deepen our understanding of natural products' role in gut-x axis health and to mitigate the global health impact of mycotoxin-induced diseases. |
| format | Journal Article |
| id | CGSpace151841 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | CGSpace1518412025-12-08T10:29:22Z Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases Li, K. Wang, S. Qu, W. Ahmed, A.A. Enneb, W. Obeidat, M.D. Liu, H.-Y. Dessie, Tadelle Kim, I.H. Adam, S.Y. Cai, D. pharmacology microbiology mycotoxins animal health genetics Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting substantial health risks. Methods: This review examines the pharmacological, toxicological, and microbiological impacts of natural products on mycotoxicosis, with a particular focus on the gut-x axis. The analysis synthesizes current understanding and explores the role of natural products rich in polysaccharides, polyphenols, flavonoids, and saponins. Results: The review highlights that mycotoxins can disrupt intestinal integrity, alter inflammatory responses, damage the mucus layer, and disturb the bacterial balance. The toxins' effects are extensive, potentially harming the immune system, liver, kidneys, and skin, and are associated with serious conditions such as cancer, hormonal changes, genetic mutations, bleeding, birth defects, and neurological issues. Natural products have shown potential anticancer, anti-tumor, antioxidant, immunomodulatory, and antitoxic properties. Discussion: The review underscores the emerging therapeutic strategy of targeting gut microbial modulation. It identifies knowledge gaps and suggests future research directions to deepen our understanding of natural products' role in gut-x axis health and to mitigate the global health impact of mycotoxin-induced diseases. 2024 2024-08-25T18:09:43Z 2024-08-25T18:09:43Z Journal Article https://hdl.handle.net/10568/151841 en Open Access Frontiers Media Li, K., Wang, S., Qu, W., Ahmed, A.A., Enneb, W., Obeidat, M.D., Liu, H.-Y., Dessie, T., Kim, I.H., Adam, S.Y. and Cai, D. 2024. Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases. Frontiers in Pharmacology 15:1419844. |
| spellingShingle | pharmacology microbiology mycotoxins animal health genetics Li, K. Wang, S. Qu, W. Ahmed, A.A. Enneb, W. Obeidat, M.D. Liu, H.-Y. Dessie, Tadelle Kim, I.H. Adam, S.Y. Cai, D. Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases |
| title | Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases |
| title_full | Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases |
| title_fullStr | Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases |
| title_full_unstemmed | Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases |
| title_short | Natural products for Gut-X axis: Pharmacology, toxicology and microbiology in mycotoxin-caused diseases |
| title_sort | natural products for gut x axis pharmacology toxicology and microbiology in mycotoxin caused diseases |
| topic | pharmacology microbiology mycotoxins animal health genetics |
| url | https://hdl.handle.net/10568/151841 |
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