Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631
Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviv...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
2008
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/1501 |
| _version_ | 1855522911724503040 |
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| author | Sironi, L. Williams, J.L. Moreno Martin, A.M. Ramelli, P. Stella, A. Weigend, S. Lombardi, G. Cordioli, P. Mariani, P. Han Jianlin |
| author_browse | Cordioli, P. Han Jianlin Lombardi, G. Mariani, P. Moreno Martin, A.M. Ramelli, P. Sironi, L. Stella, A. Weigend, S. Williams, J.L. |
| author_facet | Sironi, L. Williams, J.L. Moreno Martin, A.M. Ramelli, P. Stella, A. Weigend, S. Lombardi, G. Cordioli, P. Mariani, P. Han Jianlin |
| author_sort | Sironi, L. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation. |
| format | Journal Article |
| id | CGSpace1501 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace15012024-08-29T11:41:29Z Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631 Sironi, L. Williams, J.L. Moreno Martin, A.M. Ramelli, P. Stella, A. Weigend, S. Lombardi, G. Cordioli, P. Mariani, P. Han Jianlin animal diseases disease control chickens Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation. 2008-10 2010-05-11T17:34:13Z 2010-05-11T17:34:13Z Journal Article https://hdl.handle.net/10568/1501 en Limited Access Elsevier Sironi, L.; Williams, J.L.; Moreno-Martin, A.M.; Ramelli, P.; Stella, A.; Jianlin, H.; Weigend, S.; Lombardi, G.; Cordioli, P.; Mariani, P. 2008. Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631. Virology 380(1):52-158. |
| spellingShingle | animal diseases disease control chickens Sironi, L. Williams, J.L. Moreno Martin, A.M. Ramelli, P. Stella, A. Weigend, S. Lombardi, G. Cordioli, P. Mariani, P. Han Jianlin Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631 |
| title | Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631 |
| title_full | Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631 |
| title_fullStr | Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631 |
| title_full_unstemmed | Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631 |
| title_short | Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631 |
| title_sort | susceptibility of different chicken lines to h7n1 highly pathogenic avian influenza virus and the role of mx gene polymorphism coding amino acid position 631 |
| topic | animal diseases disease control chickens |
| url | https://hdl.handle.net/10568/1501 |
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