Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: A randomized controlled trial in Vietnam
Background Maternal health and nutrition play a crucial role in early child growth and development. However, little is known about the benefits of preconception micronutrient interventions beyond the role of folic acid (FA) and neural tube defects. Objective We evaluated the impact of weekly preconc...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Elsevier
2017
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| Online Access: | https://hdl.handle.net/10568/148145 |
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| author | Nguyen, Phuong Hong Gonzalez-Casanova, Ines Young, Melissa F. Truong, Truong V. Hoang, Hue Nguyen, Huong Nguyen, Son DiGirolamo, Ann M. Martorell, Reynaldo Ramakrishnan, Usha |
| author_browse | DiGirolamo, Ann M. Gonzalez-Casanova, Ines Hoang, Hue Martorell, Reynaldo Nguyen, Huong Nguyen, Phuong Hong Nguyen, Son Ramakrishnan, Usha Truong, Truong V. Young, Melissa F. |
| author_facet | Nguyen, Phuong Hong Gonzalez-Casanova, Ines Young, Melissa F. Truong, Truong V. Hoang, Hue Nguyen, Huong Nguyen, Son DiGirolamo, Ann M. Martorell, Reynaldo Ramakrishnan, Usha |
| author_sort | Nguyen, Phuong Hong |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background Maternal health and nutrition play a crucial role in early child growth and development. However, little is known about the benefits of preconception micronutrient interventions beyond the role of folic acid (FA) and neural tube defects. Objective We evaluated the impact of weekly preconception multiple micronutrient (MM) or iron and folic acid (IFA) supplementation on child growth and development through the age of 2 y compared with FA alone. Methods We followed 1599 offspring born to women who participated in a randomized controlled trial of preconception supplementation in Vietnam. Women received weekly supplements that contained either 2800 μg FA, 60 mg Fe and 2800 μg FA, or 15 MMs including IFA, from baseline until conception followed by daily prenatal IFA supplements until delivery. Child anthropometry was measured at birth and at 3, 6, 12, 18, and 24 mo. Child development was measured with the use of the Bayley Scales for Infant Development III at 24 mo. Results The groups were similar for baseline maternal and offspring birth characteristics. At 24 mo of age, the offspring in the IFA group had significantly higher length-for-age z scores (LAZs) (0.14; 95% CI: 0.03, 0.26), reduced risk of being stunted (0.87; 95% CI: 0.76, 0.99), and smaller yearly decline in LAZs (0.10; 95% CI: 0.04, 0.15) than the offspring in the FA group. Similar trends were found for the offspring in the MM group compared with the FA group for LAZs (0.10; 95% CI: −0.02, 0.22) and the risk of being stunted (0.88; 95% CI: 0.77, 1.01). Offspring in the IFA group had improved motor development (P = 0.03), especially fine motor development (0.41; 95% CI: 0.05, 0.77), at the age of 24 mo, but there were no differences for measures of cognition or language. Conclusions Preconception supplementation with IFA improved linear growth and fine motor development at 2 y of age compared with FA. Future studies should examine whether these effects persist and improve child health and schooling. |
| format | Journal Article |
| id | CGSpace148145 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1481452025-04-03T21:29:15Z Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: A randomized controlled trial in Vietnam Nguyen, Phuong Hong Gonzalez-Casanova, Ines Young, Melissa F. Truong, Truong V. Hoang, Hue Nguyen, Huong Nguyen, Son DiGirolamo, Ann M. Martorell, Reynaldo Ramakrishnan, Usha child development randomized controlled trial nutrition trace elements children iron folic acid child growth Background Maternal health and nutrition play a crucial role in early child growth and development. However, little is known about the benefits of preconception micronutrient interventions beyond the role of folic acid (FA) and neural tube defects. Objective We evaluated the impact of weekly preconception multiple micronutrient (MM) or iron and folic acid (IFA) supplementation on child growth and development through the age of 2 y compared with FA alone. Methods We followed 1599 offspring born to women who participated in a randomized controlled trial of preconception supplementation in Vietnam. Women received weekly supplements that contained either 2800 μg FA, 60 mg Fe and 2800 μg FA, or 15 MMs including IFA, from baseline until conception followed by daily prenatal IFA supplements until delivery. Child anthropometry was measured at birth and at 3, 6, 12, 18, and 24 mo. Child development was measured with the use of the Bayley Scales for Infant Development III at 24 mo. Results The groups were similar for baseline maternal and offspring birth characteristics. At 24 mo of age, the offspring in the IFA group had significantly higher length-for-age z scores (LAZs) (0.14; 95% CI: 0.03, 0.26), reduced risk of being stunted (0.87; 95% CI: 0.76, 0.99), and smaller yearly decline in LAZs (0.10; 95% CI: 0.04, 0.15) than the offspring in the FA group. Similar trends were found for the offspring in the MM group compared with the FA group for LAZs (0.10; 95% CI: −0.02, 0.22) and the risk of being stunted (0.88; 95% CI: 0.77, 1.01). Offspring in the IFA group had improved motor development (P = 0.03), especially fine motor development (0.41; 95% CI: 0.05, 0.77), at the age of 24 mo, but there were no differences for measures of cognition or language. Conclusions Preconception supplementation with IFA improved linear growth and fine motor development at 2 y of age compared with FA. Future studies should examine whether these effects persist and improve child health and schooling. 2017 2024-06-21T09:23:55Z 2024-06-21T09:23:55Z Journal Article https://hdl.handle.net/10568/148145 en Elsevier Nguyen, Phuong H.; Gonzalez-Casanova, Ines; Young, Melissa; Truong, Truong V.; Hoang, Hue; Nguyen, Huong; Nguyen, Son; DiGirolamo, Ann M; Martorell, Reynaldo; and Ramakrishnan, Usha. 2017. Preconception Micronutrient Supplementation with Iron and Folic Acid Compared with Folic Acid Alone Affects Linear Growth and Fine Motor Development at 2 Years of Age: A Randomized Controlled Trial in Vietnam. Journal of Nutrition 147(8): 1593-1601. https://doi.org/10.3945/jn.117.250597 |
| spellingShingle | child development randomized controlled trial nutrition trace elements children iron folic acid child growth Nguyen, Phuong Hong Gonzalez-Casanova, Ines Young, Melissa F. Truong, Truong V. Hoang, Hue Nguyen, Huong Nguyen, Son DiGirolamo, Ann M. Martorell, Reynaldo Ramakrishnan, Usha Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: A randomized controlled trial in Vietnam |
| title | Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: A randomized controlled trial in Vietnam |
| title_full | Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: A randomized controlled trial in Vietnam |
| title_fullStr | Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: A randomized controlled trial in Vietnam |
| title_full_unstemmed | Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: A randomized controlled trial in Vietnam |
| title_short | Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: A randomized controlled trial in Vietnam |
| title_sort | preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age a randomized controlled trial in vietnam |
| topic | child development randomized controlled trial nutrition trace elements children iron folic acid child growth |
| url | https://hdl.handle.net/10568/148145 |
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