Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam
Background Micronutrient malnutrition has been associated with maternal depressive symptoms (MDS), but little is known about the effects of preconceptional micronutrient supplementation. This paper examined the effects of preconceptional micronutrient supplementation on MDS during pregnancy and post...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2017
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/147805 |
| _version_ | 1855523544513904640 |
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| author | Nguyen, Phuong Hong DiGirolamo, Ann M. Gonzalez-Casanova, Ines Pham, Hoa Hao, Wei Nguyen, Hieu Truong, Truong V. Nguyen, Son Harding, Kimberly B. Reinhart, Gregory A. Martorell, Reynaldo Ramakrishnan, Usha |
| author_browse | DiGirolamo, Ann M. Gonzalez-Casanova, Ines Hao, Wei Harding, Kimberly B. Martorell, Reynaldo Nguyen, Hieu Nguyen, Phuong Hong Nguyen, Son Pham, Hoa Ramakrishnan, Usha Reinhart, Gregory A. Truong, Truong V. |
| author_facet | Nguyen, Phuong Hong DiGirolamo, Ann M. Gonzalez-Casanova, Ines Pham, Hoa Hao, Wei Nguyen, Hieu Truong, Truong V. Nguyen, Son Harding, Kimberly B. Reinhart, Gregory A. Martorell, Reynaldo Ramakrishnan, Usha |
| author_sort | Nguyen, Phuong Hong |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background Micronutrient malnutrition has been associated with maternal depressive symptoms (MDS), but little is known about the effects of preconceptional micronutrient supplementation. This paper examined the effects of preconceptional micronutrient supplementation on MDS during pregnancy and postpartum. Methods We used data from a double-blind controlled trial (PRECONCEPT) in which 5011 Vietnamese women were randomized to receive weekly supplements containing either a) multiple micronutrients (MM) b) iron and folic acid (IFA) or c) folic acid (FA) until conception (n = 1813). Maternal mental health was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D) at baseline (preconception), and the Edinburgh Postnatal Depression Scale (EPDS) during pregnancy and 3 months postpartum. Elevated MDS was defined as EPDS score ≥ 4. All group comparisons were done using ANOVA or chi-square tests of proportions intention to treat and per protocol analyses (women consumed supplements ≥26 weeks before conception). We also conducted stratified analyses by preconception CES-D scores, underweight, or anemia status using generalized linear models. Results Baseline CES-D scores were similar across treatment groups. The proportion of women experiencing elevated MDS was 11.3, 8.1 and 4.9% at first, second and third trimesters of pregnancy, respectively, and 3.6% at 3 mo postpartum. Mean EPDS scores at first (1.5 ± 2.7), second (1.1 ± 2.4), and third trimester of pregnancy (0.7 ± 2.0) and early postpartum (0.6 ± 1.8) were low and did not differ by treatment group. However, among women in the highest tertile of CES-D scores at preconception, mean EPDS scores in the first and second trimesters of pregnancy were lower in the MM and IFA groups compared to FA only (P < 0.05). Conclusions Weekly preconceptional micronutrient supplements containing iron did not improve depression measures relative to folic acid alone among all women, but may have benefitted women who were at risk for depression. |
| format | Journal Article |
| id | CGSpace147805 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1478052025-12-08T10:29:22Z Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam Nguyen, Phuong Hong DiGirolamo, Ann M. Gonzalez-Casanova, Ines Pham, Hoa Hao, Wei Nguyen, Hieu Truong, Truong V. Nguyen, Son Harding, Kimberly B. Reinhart, Gregory A. Martorell, Reynaldo Ramakrishnan, Usha mental health randomized controlled trial supplements Background Micronutrient malnutrition has been associated with maternal depressive symptoms (MDS), but little is known about the effects of preconceptional micronutrient supplementation. This paper examined the effects of preconceptional micronutrient supplementation on MDS during pregnancy and postpartum. Methods We used data from a double-blind controlled trial (PRECONCEPT) in which 5011 Vietnamese women were randomized to receive weekly supplements containing either a) multiple micronutrients (MM) b) iron and folic acid (IFA) or c) folic acid (FA) until conception (n = 1813). Maternal mental health was assessed using the Center for Epidemiologic Studies Depression Scale (CES-D) at baseline (preconception), and the Edinburgh Postnatal Depression Scale (EPDS) during pregnancy and 3 months postpartum. Elevated MDS was defined as EPDS score ≥ 4. All group comparisons were done using ANOVA or chi-square tests of proportions intention to treat and per protocol analyses (women consumed supplements ≥26 weeks before conception). We also conducted stratified analyses by preconception CES-D scores, underweight, or anemia status using generalized linear models. Results Baseline CES-D scores were similar across treatment groups. The proportion of women experiencing elevated MDS was 11.3, 8.1 and 4.9% at first, second and third trimesters of pregnancy, respectively, and 3.6% at 3 mo postpartum. Mean EPDS scores at first (1.5 ± 2.7), second (1.1 ± 2.4), and third trimester of pregnancy (0.7 ± 2.0) and early postpartum (0.6 ± 1.8) were low and did not differ by treatment group. However, among women in the highest tertile of CES-D scores at preconception, mean EPDS scores in the first and second trimesters of pregnancy were lower in the MM and IFA groups compared to FA only (P < 0.05). Conclusions Weekly preconceptional micronutrient supplements containing iron did not improve depression measures relative to folic acid alone among all women, but may have benefitted women who were at risk for depression. 2017 2024-06-21T09:23:20Z 2024-06-21T09:23:20Z Journal Article https://hdl.handle.net/10568/147805 en Springer Nguyen, Phuong H.; DiGirolamo, Ann M.; Gonzalez-Casanova, Ines; Pham, Hoa; Hao, Wei; Nguyen, Hieu; Truong, Truong V.; Nguyen, Son; Harding, Kimberly B.; Reinhart, Gregory A.; Martorell, Reynaldo; and Ramakrishnan, Usha. 2017. Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: results from a randomized controlled trial in Vietnam. BMC Women's Health 17 (44): https://doi.org/10.1186/s12905-017-0401-3 |
| spellingShingle | mental health randomized controlled trial supplements Nguyen, Phuong Hong DiGirolamo, Ann M. Gonzalez-Casanova, Ines Pham, Hoa Hao, Wei Nguyen, Hieu Truong, Truong V. Nguyen, Son Harding, Kimberly B. Reinhart, Gregory A. Martorell, Reynaldo Ramakrishnan, Usha Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam |
| title | Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam |
| title_full | Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam |
| title_fullStr | Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam |
| title_full_unstemmed | Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam |
| title_short | Impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum: Results from a randomized controlled trial in Vietnam |
| title_sort | impact of preconceptional micronutrient supplementation on maternal mental health during pregnancy and postpartum results from a randomized controlled trial in vietnam |
| topic | mental health randomized controlled trial supplements |
| url | https://hdl.handle.net/10568/147805 |
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