Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS)
**Background** Of two community-based trials among young children in neighboring health districts of Burkina Faso, one found that small-quantity lipid-based nutrient supplements (LNS) increased child growth compared with a non-intervention control group, but zinc supplementation did not in the seco...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Public Library of Science
2017
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/147458 |
| _version_ | 1855520081530847232 |
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| author | Hess, Sonja Y. Peerson, Janet M. Becquey, Elodie Abbeddou, Souheila Ouédraogo, Césaire T Somé, Jérôme W. Yakes Jimenez, Elizabeth Ouédraogo, Jean-Bosco Vosti, Stephen A. Rouamba, Noël Brown, Kenneth H. |
| author_browse | Abbeddou, Souheila Becquey, Elodie Brown, Kenneth H. Hess, Sonja Y. Ouédraogo, Césaire T Ouédraogo, Jean-Bosco Peerson, Janet M. Rouamba, Noël Somé, Jérôme W. Vosti, Stephen A. Yakes Jimenez, Elizabeth |
| author_facet | Hess, Sonja Y. Peerson, Janet M. Becquey, Elodie Abbeddou, Souheila Ouédraogo, Césaire T Somé, Jérôme W. Yakes Jimenez, Elizabeth Ouédraogo, Jean-Bosco Vosti, Stephen A. Rouamba, Noël Brown, Kenneth H. |
| author_sort | Hess, Sonja Y. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | **Background**
Of two community-based trials among young children in neighboring health districts of Burkina Faso, one found that small-quantity lipid-based nutrient supplements (LNS) increased child growth compared with a non-intervention control group, but zinc supplementation did not in the second study.
**Objectives**
We explored whether the disparate growth outcomes were associated with differences in intervention components, household demographic variables, and/or children's morbidity.
**Methods**
Children in the LNS study received 20g LNS daily containing different amounts of zinc (LNS). Children in the zinc supplementation study received different zinc supplementation regimens (Z-Suppl). Children in both studies were visited weekly for morbidity surveillance. Free malaria and diarrhea treatment was provided by the field worker in the LNS study, and by a village-based community-health worker in the zinc study. Anthropometric assessments were repeated every 13–16 weeks. For the present analyses, study intervals of the two studies were matched by child age and month of enrollment. The changes in length-for-age z-score (LAZ) per interval were compared between LNS and Z-Suppl groups using mixed model ANOVA or ANCOVA. Covariates were added to the model in blocks, and adjusted differences between group means were estimated.
**Results**
Mean ages at enrollment of LNS (n = 1716) and Z-Suppl (n = 1720) were 9.4±0.4 and 10.1±2.7 months, respectively. The age-adjusted change in mean LAZ per interval declined less with LNS (-0.07±0.44) versus Z-Suppl (-0.21±0.43; p<0.0001). There was a significant group by interval interaction with the greatest difference found in 9–12 month old children (p<0.0001). Adjusting for demographic characteristics and morbidity did not reduce the observed differences by type of intervention, even though the morbidity burden was greater in the LNS group.
**Conclusions**
Greater average physical growth in children who received LNS could not be explained by known cross-trial differences in baseline characteristics or morbidity burden, implying that the observed difference in growth response was partly due to LNS. |
| format | Journal Article |
| id | CGSpace147458 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace1474582025-01-24T14:12:27Z Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS) Hess, Sonja Y. Peerson, Janet M. Becquey, Elodie Abbeddou, Souheila Ouédraogo, Césaire T Somé, Jérôme W. Yakes Jimenez, Elizabeth Ouédraogo, Jean-Bosco Vosti, Stephen A. Rouamba, Noël Brown, Kenneth H. lipids health supplements malnutrition nutrition children zinc **Background** Of two community-based trials among young children in neighboring health districts of Burkina Faso, one found that small-quantity lipid-based nutrient supplements (LNS) increased child growth compared with a non-intervention control group, but zinc supplementation did not in the second study. **Objectives** We explored whether the disparate growth outcomes were associated with differences in intervention components, household demographic variables, and/or children's morbidity. **Methods** Children in the LNS study received 20g LNS daily containing different amounts of zinc (LNS). Children in the zinc supplementation study received different zinc supplementation regimens (Z-Suppl). Children in both studies were visited weekly for morbidity surveillance. Free malaria and diarrhea treatment was provided by the field worker in the LNS study, and by a village-based community-health worker in the zinc study. Anthropometric assessments were repeated every 13–16 weeks. For the present analyses, study intervals of the two studies were matched by child age and month of enrollment. The changes in length-for-age z-score (LAZ) per interval were compared between LNS and Z-Suppl groups using mixed model ANOVA or ANCOVA. Covariates were added to the model in blocks, and adjusted differences between group means were estimated. **Results** Mean ages at enrollment of LNS (n = 1716) and Z-Suppl (n = 1720) were 9.4±0.4 and 10.1±2.7 months, respectively. The age-adjusted change in mean LAZ per interval declined less with LNS (-0.07±0.44) versus Z-Suppl (-0.21±0.43; p<0.0001). There was a significant group by interval interaction with the greatest difference found in 9–12 month old children (p<0.0001). Adjusting for demographic characteristics and morbidity did not reduce the observed differences by type of intervention, even though the morbidity burden was greater in the LNS group. **Conclusions** Greater average physical growth in children who received LNS could not be explained by known cross-trial differences in baseline characteristics or morbidity burden, implying that the observed difference in growth response was partly due to LNS. 2017 2024-06-21T09:22:54Z 2024-06-21T09:22:54Z Journal Article https://hdl.handle.net/10568/147458 en Open Access Public Library of Science Hess, Sonja Y.; Peerson, Janet M.; Becquey, Elodie; Abbeddou, Souheila; Ouédraogo, Césaire T.; Somé, Jérôme W.; Yakes Jimenez, Elizabeth; Ouédraogo, Jean-Bosco; Vosti, Stephen A.; Rouamba, Noël; and Brown, Kenneth H. 2017. Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS). PLoS ONE 12(8): e0181770. https://doi.org/10.1371/journal.pone.0181770 |
| spellingShingle | lipids health supplements malnutrition nutrition children zinc Hess, Sonja Y. Peerson, Janet M. Becquey, Elodie Abbeddou, Souheila Ouédraogo, Césaire T Somé, Jérôme W. Yakes Jimenez, Elizabeth Ouédraogo, Jean-Bosco Vosti, Stephen A. Rouamba, Noël Brown, Kenneth H. Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS) |
| title | Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS) |
| title_full | Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS) |
| title_fullStr | Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS) |
| title_full_unstemmed | Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS) |
| title_short | Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS) |
| title_sort | differing growth responses to nutritional supplements in neighboring health districts of burkina faso are likely due to benefits of small quantity lipid based nutrient supplements lns |
| topic | lipids health supplements malnutrition nutrition children zinc |
| url | https://hdl.handle.net/10568/147458 |
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