Global increase and geographic convergence in antibiotic consumption between 2000 and 2015
Tracking antibiotic consumption patterns over time and across countries could inform policies to optimize antibiotic prescribing and minimize antibiotic resistance, such as setting and enforcing per capita consumption targets or aiding investments in alternatives to antibiotics. In this study, we an...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Proceedings of the National Academy of Sciences
2018
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/147091 |
| _version_ | 1855533653067563008 |
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| author | Klein, Eili Y. Van Boekel, Thomas P. Martinez, Elena M. Pant, Suraj Gandra, Sumanth Levin, Simon A. Goossens, Herman Laxminarayan, Ramanan |
| author_browse | Gandra, Sumanth Goossens, Herman Klein, Eili Y. Laxminarayan, Ramanan Levin, Simon A. Martinez, Elena M. Pant, Suraj Van Boekel, Thomas P. |
| author_facet | Klein, Eili Y. Van Boekel, Thomas P. Martinez, Elena M. Pant, Suraj Gandra, Sumanth Levin, Simon A. Goossens, Herman Laxminarayan, Ramanan |
| author_sort | Klein, Eili Y. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Tracking antibiotic consumption patterns over time and across countries could inform policies to optimize antibiotic prescribing and minimize antibiotic resistance, such as setting and enforcing per capita consumption targets or aiding investments in alternatives to antibiotics. In this study, we analyzed the trends and drivers of antibiotic consumption from 2000 to 2015 in 76 countries and projected total global antibiotic consumption through 2030. Between 2000 and 2015, antibiotic consumption, expressed in defined daily doses (DDD), increased 65% (21.1–34.8 billion DDDs), and the antibiotic consumption rate increased 39% (11.3–15.7 DDDs per 1,000 inhabitants per day). The increase was driven by low- and middle-income countries (LMICs), where rising consumption was correlated with gross domestic product per capita (GDPPC) growth (P = 0.004). In high-income countries (HICs), although overall consumption increased modestly, DDDs per 1,000 inhabitants per day fell 4%, and there was no correlation with GDPPC. Of particular concern was the rapid increase in the use of last-resort compounds, both in HICs and LMICs, such as glycylcyclines, oxazolidinones, carbapenems, and polymyxins. Projections of global antibiotic consumption in 2030, assuming no policy changes, were up to 200% higher than the 42 billion DDDs estimated in 2015. Although antibiotic consumption rates in most LMICs remain lower than in HICs despite higher bacterial disease burden, consumption in LMICs is rapidly converging to rates similar to HICs. Reducing global consumption is critical for reducing the threat of antibiotic resistance, but reduction efforts must balance access limitations in LMICs and take account of local and global resistance patterns. |
| format | Journal Article |
| id | CGSpace147091 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Proceedings of the National Academy of Sciences |
| publisherStr | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | CGSpace1470912024-10-25T08:00:19Z Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 Klein, Eili Y. Van Boekel, Thomas P. Martinez, Elena M. Pant, Suraj Gandra, Sumanth Levin, Simon A. Goossens, Herman Laxminarayan, Ramanan resistance to antibiotics food supplements drugs health diseases developing countries antimicrobial resistance antibiotics Tracking antibiotic consumption patterns over time and across countries could inform policies to optimize antibiotic prescribing and minimize antibiotic resistance, such as setting and enforcing per capita consumption targets or aiding investments in alternatives to antibiotics. In this study, we analyzed the trends and drivers of antibiotic consumption from 2000 to 2015 in 76 countries and projected total global antibiotic consumption through 2030. Between 2000 and 2015, antibiotic consumption, expressed in defined daily doses (DDD), increased 65% (21.1–34.8 billion DDDs), and the antibiotic consumption rate increased 39% (11.3–15.7 DDDs per 1,000 inhabitants per day). The increase was driven by low- and middle-income countries (LMICs), where rising consumption was correlated with gross domestic product per capita (GDPPC) growth (P = 0.004). In high-income countries (HICs), although overall consumption increased modestly, DDDs per 1,000 inhabitants per day fell 4%, and there was no correlation with GDPPC. Of particular concern was the rapid increase in the use of last-resort compounds, both in HICs and LMICs, such as glycylcyclines, oxazolidinones, carbapenems, and polymyxins. Projections of global antibiotic consumption in 2030, assuming no policy changes, were up to 200% higher than the 42 billion DDDs estimated in 2015. Although antibiotic consumption rates in most LMICs remain lower than in HICs despite higher bacterial disease burden, consumption in LMICs is rapidly converging to rates similar to HICs. Reducing global consumption is critical for reducing the threat of antibiotic resistance, but reduction efforts must balance access limitations in LMICs and take account of local and global resistance patterns. 2018-12-18 2024-06-21T09:11:10Z 2024-06-21T09:11:10Z Journal Article https://hdl.handle.net/10568/147091 en Open Access Proceedings of the National Academy of Sciences Klein, Eili Y.; Van Boekel, Thomas P.; Martinez, Elena M.; Pant, Suraj; Gandra, Sumanth; Levin, Simon A.; Goossens, Herman; and Laxminarayan, Ramanan. 2018. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 115 (15): E3463-E3470. https://doi.org/10.1073/pnas.1717295115 |
| spellingShingle | resistance to antibiotics food supplements drugs health diseases developing countries antimicrobial resistance antibiotics Klein, Eili Y. Van Boekel, Thomas P. Martinez, Elena M. Pant, Suraj Gandra, Sumanth Levin, Simon A. Goossens, Herman Laxminarayan, Ramanan Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 |
| title | Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 |
| title_full | Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 |
| title_fullStr | Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 |
| title_full_unstemmed | Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 |
| title_short | Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 |
| title_sort | global increase and geographic convergence in antibiotic consumption between 2000 and 2015 |
| topic | resistance to antibiotics food supplements drugs health diseases developing countries antimicrobial resistance antibiotics |
| url | https://hdl.handle.net/10568/147091 |
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