Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies
Vitamin A (VA) deficiency is a serious public health problem, especially in preschool children who are at risk of increased mortality. In order to address this problem, the World Health Organization recommends periodic high‐dose supplementation to children 6–59 months of age in areas of highest risk...
| Autores principales: | , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
John Wiley & Sons
2019
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| Acceso en línea: | https://hdl.handle.net/10568/145518 |
| _version_ | 1855537381033115648 |
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| author | Tanumihardjo, Sherry A. Kaliwile, Chisela Boy, Erick Dhansay, Muhammad A. van Stuijvenberg, Martha E. |
| author_browse | Boy, Erick Dhansay, Muhammad A. Kaliwile, Chisela Tanumihardjo, Sherry A. van Stuijvenberg, Martha E. |
| author_facet | Tanumihardjo, Sherry A. Kaliwile, Chisela Boy, Erick Dhansay, Muhammad A. van Stuijvenberg, Martha E. |
| author_sort | Tanumihardjo, Sherry A. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Vitamin A (VA) deficiency is a serious public health problem, especially in preschool children who are at risk of increased mortality. In order to address this problem, the World Health Organization recommends periodic high‐dose supplementation to children 6–59 months of age in areas of highest risk. Originally, supplementation was meant as a short‐term solution until more sustainable interventions could be adopted. Currently, many countries are fortifying commercialized common staple and snack foods with retinyl palmitate. However, in some countries, overlapping programs may lead to excessive intakes. Our review uses case studies in the United States, Guatemala, Zambia, and South Africa to illustrate the potential for excessive intakes in some groups. For example, direct liver analysis from 27 U.S. adult cadavers revealed 33% prevalence of hypervitaminosis A (defined as ≥1 μmol/g liver). In 133 Zambian children, 59% were diagnosed with hypervitaminosis A using a retinol isotope dilution, and 16% had ≥5% total serum VA as retinyl esters, a measure of intoxication. In 40 South African children who frequently consumed liver, 72.5% had ≥5% total serum VA as retinyl esters. All four countries have mandatory fortified foods and a high percentage of supplement users or targeted supplementation to preschool children. |
| format | Journal Article |
| id | CGSpace145518 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | John Wiley & Sons |
| publisherStr | John Wiley & Sons |
| record_format | dspace |
| spelling | CGSpace1455182024-10-25T08:04:43Z Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies Tanumihardjo, Sherry A. Kaliwile, Chisela Boy, Erick Dhansay, Muhammad A. van Stuijvenberg, Martha E. health retinol supplements nutrition food fortification Vitamin A (VA) deficiency is a serious public health problem, especially in preschool children who are at risk of increased mortality. In order to address this problem, the World Health Organization recommends periodic high‐dose supplementation to children 6–59 months of age in areas of highest risk. Originally, supplementation was meant as a short‐term solution until more sustainable interventions could be adopted. Currently, many countries are fortifying commercialized common staple and snack foods with retinyl palmitate. However, in some countries, overlapping programs may lead to excessive intakes. Our review uses case studies in the United States, Guatemala, Zambia, and South Africa to illustrate the potential for excessive intakes in some groups. For example, direct liver analysis from 27 U.S. adult cadavers revealed 33% prevalence of hypervitaminosis A (defined as ≥1 μmol/g liver). In 133 Zambian children, 59% were diagnosed with hypervitaminosis A using a retinol isotope dilution, and 16% had ≥5% total serum VA as retinyl esters, a measure of intoxication. In 40 South African children who frequently consumed liver, 72.5% had ≥5% total serum VA as retinyl esters. All four countries have mandatory fortified foods and a high percentage of supplement users or targeted supplementation to preschool children. 2019-06 2024-06-21T09:04:36Z 2024-06-21T09:04:36Z Journal Article https://hdl.handle.net/10568/145518 en Open Access John Wiley & Sons Tanumihardjo, Sherry A.; Kaliwile, Chisela; Boy, Erick; Dhansay, Muhammad A.; and van Stuijvenberg, Martha E. 2019. Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies. Annals of the New York Academy of Sciences 1446(1): 102-116. https://doi.org/10.1111/nyas.13965 |
| spellingShingle | health retinol supplements nutrition food fortification Tanumihardjo, Sherry A. Kaliwile, Chisela Boy, Erick Dhansay, Muhammad A. van Stuijvenberg, Martha E. Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies |
| title | Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies |
| title_full | Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies |
| title_fullStr | Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies |
| title_full_unstemmed | Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies |
| title_short | Overlapping vitamin A interventions in the United States, Guatemala, Zambia, and South Africa: Case studies |
| title_sort | overlapping vitamin a interventions in the united states guatemala zambia and south africa case studies |
| topic | health retinol supplements nutrition food fortification |
| url | https://hdl.handle.net/10568/145518 |
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