Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat
Genomics and genome editing promise enormous opportunities for crop improvement and elementary research. Precise modification in the specific targeted location of a genome has profited over the unplanned insertional events which are generally accomplished employing unadventurous means of genetic mod...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Frontiers Media
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/145002 |
| _version_ | 1855523256027578368 |
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| author | Singh, Charul Kumar, Ramesh Sehgal, Hansa Bhati, Sharmista Singhal, Tripti G, Gayacharan Nimmy, M S Yadav, Renu Gupta, Santosh Kumar Naglaa A, Abdallah Hamwieh, Aladdin Kumar, Rajendra |
| author_browse | Bhati, Sharmista G, Gayacharan Gupta, Santosh Kumar Hamwieh, Aladdin Kumar, Rajendra Kumar, Ramesh Naglaa A, Abdallah Nimmy, M S Sehgal, Hansa Singh, Charul Singhal, Tripti Yadav, Renu |
| author_facet | Singh, Charul Kumar, Ramesh Sehgal, Hansa Bhati, Sharmista Singhal, Tripti G, Gayacharan Nimmy, M S Yadav, Renu Gupta, Santosh Kumar Naglaa A, Abdallah Hamwieh, Aladdin Kumar, Rajendra |
| author_sort | Singh, Charul |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Genomics and genome editing promise enormous opportunities for crop improvement and elementary research. Precise modification in the specific targeted location of a genome has profited over the unplanned insertional events which are generally accomplished employing unadventurous means of genetic modifications. The advent of new genome editing procedures viz; zinc finger nucleases (ZFNs), homing endonucleases, transcription activator like effector nucleases (TALENs), Base Editors (BEs), and Primer Editors (PEs) enable molecular scientists to modulate gene expressions or create novel genes with high precision and efficiency. However, all these techniques are exorbitant and tedious since their prerequisites are difficult processes that necessitate protein engineering. Contrary to first generation genome modifying methods, CRISPR/ Cas9 is simple to construct, and clones can hypothetically target several locations in the genome with different guide RNAs. Following the model of the application in crop with the help of the CRISPR/Cas9 module, various customized Cas9 cassettes have been cast off to advance mark discrimination and diminish random cuts. The present study discusses the progression in genome editing apparatuses, and their applications in chickpea crop development, scientific limitations, and future perspectives for biofortifying cytokinin dehydrogenase, nitrate reductase, superoxide dismutase to induce drought resistance, heat tolerance and higher yield in chickpea to encounter global climate change, hunger and nutritional threats. |
| format | Journal Article |
| id | CGSpace145002 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | CGSpace1450022026-01-15T02:06:54Z Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat Singh, Charul Kumar, Ramesh Sehgal, Hansa Bhati, Sharmista Singhal, Tripti G, Gayacharan Nimmy, M S Yadav, Renu Gupta, Santosh Kumar Naglaa A, Abdallah Hamwieh, Aladdin Kumar, Rajendra climate change genome editing chickpea chickpea improvement crispr/cas-9 hunger threat zinc finger nuclease Genomics and genome editing promise enormous opportunities for crop improvement and elementary research. Precise modification in the specific targeted location of a genome has profited over the unplanned insertional events which are generally accomplished employing unadventurous means of genetic modifications. The advent of new genome editing procedures viz; zinc finger nucleases (ZFNs), homing endonucleases, transcription activator like effector nucleases (TALENs), Base Editors (BEs), and Primer Editors (PEs) enable molecular scientists to modulate gene expressions or create novel genes with high precision and efficiency. However, all these techniques are exorbitant and tedious since their prerequisites are difficult processes that necessitate protein engineering. Contrary to first generation genome modifying methods, CRISPR/ Cas9 is simple to construct, and clones can hypothetically target several locations in the genome with different guide RNAs. Following the model of the application in crop with the help of the CRISPR/Cas9 module, various customized Cas9 cassettes have been cast off to advance mark discrimination and diminish random cuts. The present study discusses the progression in genome editing apparatuses, and their applications in chickpea crop development, scientific limitations, and future perspectives for biofortifying cytokinin dehydrogenase, nitrate reductase, superoxide dismutase to induce drought resistance, heat tolerance and higher yield in chickpea to encounter global climate change, hunger and nutritional threats. 2023-04-18 Journal Article https://hdl.handle.net/10568/145002 en Open Access application/pdf Frontiers Media Charul Singh, Ramesh Kumar, Hansa Sehgal, Sharmista Bhati, Tripti Singhal, Gayacharan G, M S Nimmy, Renu Yadav, Santosh Kumar Gupta, Abdallah Naglaa A, Aladdin Hamwieh, Rajendra Kumar. (18/4/2023). Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat. Frontiers in Genetics, 14. |
| spellingShingle | climate change genome editing chickpea chickpea improvement crispr/cas-9 hunger threat zinc finger nuclease Singh, Charul Kumar, Ramesh Sehgal, Hansa Bhati, Sharmista Singhal, Tripti G, Gayacharan Nimmy, M S Yadav, Renu Gupta, Santosh Kumar Naglaa A, Abdallah Hamwieh, Aladdin Kumar, Rajendra Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat |
| title | Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat |
| title_full | Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat |
| title_fullStr | Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat |
| title_full_unstemmed | Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat |
| title_short | Unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat |
| title_sort | unclasping potentials of genomics and gene editing in chickpea to fight climate change and global hunger threat |
| topic | climate change genome editing chickpea chickpea improvement crispr/cas-9 hunger threat zinc finger nuclease |
| url | https://hdl.handle.net/10568/145002 |
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